Patents by Inventor David Idris Pritchard
David Idris Pritchard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8049020Abstract: The substituted N-acyl homoserine lactones have the formula (I) wherein R is a saturated or unsaturated straight chain or branched chain aliphatic hydrocarbyl group containing from 5 to 14 carbon atoms; R2 is H or a 1-4C alkyl group; R3 is H or F; and any enantiomer thereof. These compounds exhibit immunosuppressant activity while exhibiting reduced biosensor (autoinducer) activity compared to known N-acyl homoserine lactones.Type: GrantFiled: May 22, 2007Date of Patent: November 1, 2011Assignee: The Secretary of State for DefenceInventors: David Idris Pritchard, Siri Ram Chhabra
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Publication number: 20100286261Abstract: The substituted N-acyl homoserine lactones have the formula (I) wherein R is a saturated or unsaturated straight chain or branched chain aliphatic hydrocarbyl group containing from 5 to 14 carbon atoms; R2 is H or a 1-4C alkyl group; R3 is H or F; and any enantiomer thereof. These compounds exhibit immunosuppressant activity while exhibiting reduced biosensor (autoinducer) activity compared to known N-acyl homoserine lactones.Type: ApplicationFiled: May 22, 2007Publication date: November 11, 2010Inventors: David Idris Pritchard, Siri Ram Chhabra
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Publication number: 20100008898Abstract: The use of larval enzymes, particularly a chymotrypsin, is described herein. The enzymes are usable in the treatment of wounds for debridement and for cell regeneration.Type: ApplicationFiled: May 31, 2007Publication date: January 14, 2010Inventors: David Idris Pritchard, Adele J. Horobin, Alan Brown
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Publication number: 20090304668Abstract: This invention relates to a polypeptide obtainable from insect larvae, such as those from Lucilia sericata, and which have activity as a nuclease in that they are able to degrade, denature, digest, cut or cleave nucleic acids such as DNA.Type: ApplicationFiled: April 13, 2007Publication date: December 10, 2009Applicant: The Secretary of State for DefenceInventors: David Idris Pritchard, Adele J. Horobin, Alan Brown
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Patent number: 7482362Abstract: Substituted-4-quinolones of the formula (I): wherein R1 is a straight or branched chain, saturated or ethylenically-unsaturated aliphatic hydrocarbyl group containing 1 to 18 carbon atoms which may optionally be substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR6R7, wherein each of R6 and R7 is independently selected from H and 1-6C alkyl or R6 and R7 together with the N atom to which they are attached form a saturated heterocyclic group selected from piperidino, piperazino and morpholino; R2 is a group selected from H, —OH, halo, —CHO, —CO2H and CONHR8 wherein R8 is H or a 1-6C alkyl; each of R3, R4 and R5 is independently selected form H, —CH3, —OCH3 and halo; or a non-toxic pharmaceutically-acceptable salt thereof, have use in the manufacture of a medicament for the treatment of a disease of a living animal body, including a human, which disease is responsive to the activity of an immunosuppressant.Type: GrantFiled: December 17, 2001Date of Patent: January 27, 2009Assignee: The Secretary of State for DefenseInventors: David Idris Pritchard, Barrie Walsham Bycroft, Siri Ram Chhabra, Doreen Hooi
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Patent number: 7371779Abstract: A composition having immunosuppressant activity comprises at least one compound of the formula (I) in which R is an acyl group of the formula (II) wherein one of R1 and R2 is H and the other is selected from OR4, SR4 and NHR4, wherein R4 is H or 1-6C alkyl, or R1 and R2 together with the carbon atom to which they are joined form a keto group, and R3 is a straight or branched chain, saturated or unsaturated aliphatic hydrocarbyl group containing from 8 to 11 carbon atoms and is optionally substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR5R6 wherein each of R5 and R6 is selected from H and 1-6C alkyl or R5 and R6 together with the N atom form a morpholino or piperazino group, or any enantiomer thereof; and at least one compound of the formula (III): wherein R7 is a straight or branched chain, saturated or ethylenically-unsaturated aliphatic hydrocarbyl group containing from 1 to 18 carbon atoms which may optionally be substituted by one or more suType: GrantFiled: July 3, 2002Date of Patent: May 13, 2008Assignee: The Secretary of State for Defense Science and TechnologyInventor: David Idris Pritchard
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Patent number: 7161059Abstract: A method for maintaining a human hookworm strain is provided by infecting a non-human primate with a non-adapted or non-passaged human hookworm and maintaining the non-human primate. Methods of obtaining human hookworm materials and compositions, such as for use as a vaccine, are also provided, along with a model for maintaining and investigating human hookworm.Type: GrantFiled: February 17, 2004Date of Patent: January 9, 2007Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventors: Alan Brown, Doreen S W Hooi, David Idris Pritchard, Gareth David Griffiths, Peter Colin Pearce, Elizabeth Ann Marie Scott
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Patent number: 7144721Abstract: An isolated protein, for use in treatment of wounds, is characterized in that it is secreted by the organism Lucilia sericata and it exhibits proteolytic activity against FITC-casein at a pH of 8.0 to 8.5. The protein exhibits proteolytic activity against Tosyl-Gly-Pro-Arg-AMC but not against Suc-Ala-Ala-Phe-AMC, and its proteolytic activity against FITC-casein and Tosyl-Gly-Pro-Arg-AMC is inhibited by the serine proteinase inhibitors PMSF and AMPSF. The protein is also bound by immobilized aminobenzamidine.Type: GrantFiled: October 20, 2000Date of Patent: December 5, 2006Assignee: The Secretary of the State of Defense, Defence Science and Technology Laboratory of Porton DownInventor: David Idris Pritchard
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Publication number: 20040198978Abstract: A composition having immunosuppressant activity comprises at least one compound of the formula (I) in which R is an acyl group of the formula (II) wherein one of R1 and R2 is H and the other is selected from OR4, SR4 and NHR4, wherein R4 is H or 1-6C alkyl, or R1 and R2 together with the carbon atom to which they are joined form a keto group, and R3 is a straight or branched chain, saturated or unsaturated aliphatic hydrocarbyl group containing from 8 to 11 carbon atoms and is optionally substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR5R6 wherein each of R5 and R6 is selected from H and 1-6C alkyl or R5 and R6 together with the N atom form a morpholino or piperazino group, or any enantiomer thereof; and at least one compound of the formula (III): wherein R7 is a straight or branched chain, saturated or ethylenically-unsaturated aliphatic hydrocarbyl group containing from 1 to 18 carbon atoms which may optionally be substituted by one or more suType: ApplicationFiled: May 18, 2004Publication date: October 7, 2004Inventor: David Idris Pritchard
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Publication number: 20040082579Abstract: Substituted-4-quinolones of the formula (I): wherein R1 is a straight or branched chain, saturated or ethylenically-unsaturated aliphatic hydrocarbyl group containing 1 to 18 carbon atoms which may optionally be substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR6R7, wherein each of R6 and R7 is independently selected from H and 1-6C alkyl or R6 and R7 together with the N atom to which they are attached form a saturated heterocyclic group selected from piperidino, piperazino and morpholino. R2 is a group selected from H, —OH, halo, —CHO, —CO2H and CONHR8 wherein R8 is H or a 1-6C alkyl; each of R3, R4 and R1 is independently selected form H, —CH3, —OCH3 and halo; or a non-toxic pharmaceutically-acceptable salt thereof, have use in the manufacture of a medicament for the treatment of a disease of a living animal body, including a human, which disease is responsive to the activity of an immunosuppressant.Type: ApplicationFiled: December 1, 2003Publication date: April 29, 2004Inventors: David Idris Pritchard, Barrie Walsham Bycroft, Siri Ram Chhabra, Doreen Hooi
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Publication number: 20040058017Abstract: A substantially pure excretory-secretory product is isolatable from Necator americanus and is capable of inducing apoptosis in reactive T cells.Type: ApplicationFiled: September 22, 2003Publication date: March 25, 2004Inventors: Sek Chuen Chow, David Idris Pritchard
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Publication number: 20030176382Abstract: Vaccine compositions for the treatment of hookworm infections comprise antigenic fragments of aspartyl proteinases obtainable from Necator americanus.Type: ApplicationFiled: November 25, 2002Publication date: September 18, 2003Inventor: David Idris Pritchard
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Publication number: 20030171371Abstract: New N-acyl homoserine lactone compounds of the formula (I) in whichR is an acyl group of the formula (II) wherein one of R1 and R2 is H and the other is selected from OR4, SR4 and NHR4, wherein R4 is H or 1-6C alkyl, or R1 and R2 together with the carbon atom to which they are joined form a keto group, and R3 containing from 8 to 11 carbon atoms and is optionally substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, carbamoyl optionally mono- or disubstituted at the N atom by 1-6C alkyl and NR5R6 wherein each of R5 and R6 is selected from H and 1-6C alkyl or R5 and R6 together with the N atom form a morpholino or piperazino group, or and enantiomer thereof, with the proviso that R is not a 3-oxododecanoyl group, having immuosuppressant properties are disclosed. The compounds are shown to have an inhibitory effect on lymphocyte proliferation and down-regulate TNF-&agr; secretion by monocytes/macrophages in the animal body, including the human body.Type: ApplicationFiled: February 12, 2003Publication date: September 11, 2003Inventors: Barrie Walsham Bycroft, David Idris Pritchard, Siri Ram Chhabra, Doreen Hooi
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Patent number: 6602905Abstract: Compounds having anti-fibrotic effects are provided. Also provided is a method for treating disorders, diseases or conditions associated with pathological fibrotic states. The compounds useful in the present invention are homocysteine thiolactone and selected derivatives thereof.Type: GrantFiled: August 21, 2002Date of Patent: August 5, 2003Assignee: The University of NottinghamInventors: Sheila Margaret Gardiner, Terence Bennett, Barrie Walsham Bycroft, David Idris Pritchard, Paul Williams
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Patent number: 6521263Abstract: An immunosuppressive agent, obtainable from the nematode Heligmosomoides polygyrus, characterised in that the agent has a molecular weight of less than 12 kDa, is resistant to proteinase K and is not bound to a polypeptide.Type: GrantFiled: June 25, 2001Date of Patent: February 18, 2003Assignee: University of NottinghamInventors: David Idris Pritchard, Paul Williams