Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Filter assemblies with adhesive attachment systems are provided. In one embodiment, a filter assembly includes a porous filter member and an adhesive disposed on a reinforcement scrim adhesively attached to at least a portion of at least one major surface of the porous filter member, wherein the reinforcement scrim has discrete open areas. In an alternative embodiment, a filter assembly includes a porous filter member that includes fibrous filter media and an adhesive impregnated into discrete regions of the porous filter member such that there is a substantially continuous adhesive region throughout at least about 25% of the thickness of the porous filter member in the discrete regions.

Abstract: There is provided a method of forming a shaped sorbent filter preferably having a three dimensional shape. The method generally entails: a) providing porous flexible tubular web structure having two open ends; b) sealing a first end of the tubular web structure; c) filling the sealed tubular web structure with flowable filter material of sorbent material and binder; d) sealing the opposite open end of the tubular web material; and e) heating the tubular web structure to active the binder and form a shaped sorbent filter. The tubular web structure preferably is deformed while it is heated so that there is provided at least one permanently deformed bending portion. The invention method provides a simple effective process for forming complex overwrapped shaped small sorbent filters for use in the electronics industry.

Abstract: An abrasion resistant prosthetic ligament or tendon includes a strap-like element formed of a stable biocompatible material which is attached at opposite ends to a patient. Attached to the strap-like element are one or more protective layers having sacrificial areas which are positioned in areas where abrasion between the prosthetic ligament and the patient's bones is anticipated. The sacrificial areas can be substantially abraided before any significant loss of strenth occurs, because the sacrificial areas are non-load-bearing, and protect the strap-like element from abrasion.