Patents by Inventor David J. Beebe

David J. Beebe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10441950
    Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: October 15, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
  • Patent number: 10434513
    Abstract: A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a central region communicating with the upper surface. The central region is adapted for receiving a droplet of fluid thereon. The central region includes an outer periphery that defines a first fluid constraint configured for discouraging fluid on the central region from flowing therepast. A second fluid constraint extends about the first fluid constraint. The second fluid constraint is configured for discouraging fluid flowing therepast. A third fluid constraint extends about the second fluid constraint. The third fluid constraint configured for discouraging fluid flowing therepast.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: October 8, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, David J. Guckenberger, Jr., Scott M. Berry, Hannah M. Pezzi
  • Patent number: 10391495
    Abstract: A deformable well structure for a microtiter plate and method are provided. The deformable well structure includes a sample container defining a well for receiving a sample therein. The sample received in the well has a concave meniscus. A deformation tool is engageable with the sample container and is moveable between a first disengaged position wherein the deformation tool is spaced from the sample container and a second, engaged position wherein the deformation tool engages and deforms at least a portion of the sample container such that the meniscus of the sample in the well is converted from concave to convex.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: August 27, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, David J. Guckenberger, Jr., Hannah M. Pezzi, Scott M. Berry
  • Publication number: 20190232274
    Abstract: A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends. The second end of the body is configured for connection to the tip. A plunger is slidably received in the chamber at the first end of the body. The plunger is moveable in the chamber between an extended position and a discharge position wherein the fluid is urged from tip through the orifice. An air discharge arrangement is configured to allow air from the chamber to escape therefrom and to maintain the fluid in the tip in response to connection of the second end of the body to the tip.
    Type: Application
    Filed: April 5, 2019
    Publication date: August 1, 2019
    Inventors: David J. Beebe, David J. Guckenberger, JR.
  • Patent number: 10293336
    Abstract: A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends. The second end of the body is configured for connection to the tip. A plunger is slidably received in the chamber at the first end of the body. The plunger is moveable in the chamber between an extended position and a discharge position wherein the fluid is urged from tip through the orifice. An air discharge arrangement is configured to allow air from the chamber to escape therefrom and to maintain the fluid in the tip in response to connection of the second end of the body to the tip.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 21, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, David J. Guckenberger, Jr.
  • Publication number: 20180318827
    Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.
    Type: Application
    Filed: July 17, 2018
    Publication date: November 8, 2018
    Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
  • Patent number: 10040062
    Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: August 7, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
  • Publication number: 20180155706
    Abstract: A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a second location. A plurality of solid phase substrate are deposited at the first location and a plurality of particles are added to the plurality of solid phase substrate. A force is generated to draw the plurality of solid phase substrate from the first location to a second location. The plurality of particles causes clumps of the plurality of solid phase substrate to break apart as the plurality of solid phase substrate are moved in response to the force.
    Type: Application
    Filed: December 6, 2016
    Publication date: June 7, 2018
    Inventors: David J. Beebe, David J. Guckenberger, JR., Hannah M. Pezzi
  • Publication number: 20180095018
    Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.
    Type: Application
    Filed: August 30, 2017
    Publication date: April 5, 2018
    Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
  • Publication number: 20180085748
    Abstract: A device and method are provided to facilitate the handling of a volume or fluid. The device includes an elongated tube having an open first end and a second end. The tube defines a reservoir for receiving the volume or fluid. A stanchion has a first end received within the reservoir of the tube and a second end projecting from the open end of the elongated tube. In operation, the elongated tube is deposited in a first capsule having fluid therein. The first capsule is centrifuged such that the volume of fluid is received in a reservoir in the tube through the open end. The tube is removed from the first capsule and positioned in a second capsule such that the open end of the tube is spaced from a closed end of the second capsule. The second capsule is centrifuged such that the volume of fluid is expelled from the reservoir of the tube.
    Type: Application
    Filed: September 27, 2016
    Publication date: March 29, 2018
    Inventors: David J. Beebe, Jay W. Warrick, David J. Guckenberger, JR.
  • Publication number: 20180050338
    Abstract: A deformable well structure for a microtiter plate and method are provided. The deformable well structure includes a sample container defining a well for receiving a sample therein. The sample received in the well has a concave meniscus. A deformation tool is engageable with the sample container and is moveable between a first disengaged position wherein the deformation tool is spaced from the sample container and a second, engaged position wherein the deformation tool engages and deforms at least a portion of the sample container such that the meniscus of the sample in the well is converted from concave to convex.
    Type: Application
    Filed: August 22, 2016
    Publication date: February 22, 2018
    Inventors: David J. Beebe, David J. Guckenberger, JR., Hannah M. Pezzi, Scott M. Berry
  • Patent number: 9867974
    Abstract: A device is provided for the administration of a compound in a body. The device includes a capsule having a reservoir therein for receiving the compound therein and a delivery instrument for positioning the capsule within the body. The delivery instrument includes a barrel having an interior adapted to receive the capsule therein and a dispersal element interacting with the barrel to selectively expel the capsule therefrom and into the body. A diffusion regulator communicates with the reservoir and controls the diffusion of the compound from the reservoir into the body. A retention structure projects from capsule and is configured to retain the capsule at a desired location within the body. Multiple devices may be used in conjunction to provide a multiplexed point source to administer multiple compounds simultaneously in vivo.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: January 16, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Mark E. Burkard, Jay W. Warrick, David J Guckenberger, Lee G. Wilke
  • Publication number: 20170354964
    Abstract: A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends. The second end of the body is configured for connection to the tip. A plunger is slidably received in the chamber at the first end of the body. The plunger is moveable in the chamber between an extended position and a discharge position wherein the fluid is urged from tip through the orifice. An air discharge arrangement is configured to allow air from the chamber to escape therefrom and to maintain the fluid in the tip in response to connection of the second end of the body to the tip.
    Type: Application
    Filed: June 8, 2016
    Publication date: December 14, 2017
    Inventors: David J. Beebe, David J. Guckenberger, JR.
  • Publication number: 20170356829
    Abstract: A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a central region communicating with the upper surface. The central region is adapted for receiving a droplet of fluid thereon. The central region includes an outer periphery that defines a first fluid constraint configured for discouraging fluid on the central region from flowing therepast. A second fluid constraint extends about the first fluid constraint. The second fluid constraint is configured for discouraging fluid flowing therepast. A third fluid constraint extends about the second fluid constraint. The third fluid constraint configured for discouraging fluid flowing therepast.
    Type: Application
    Filed: June 8, 2016
    Publication date: December 14, 2017
    Inventors: David J. Beebe, David J. Guckenberger, JR., Scott M. Berry, Hannah M. Pezzi
  • Patent number: 9766166
    Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: September 19, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
  • Patent number: 9518903
    Abstract: An adapter for a sliding head of a sample processing system is provided that includes a plate and a magnet mounting recess wall. The plate includes a top surface, a bottom surface, a front wall extending between the top surface and the bottom surface, and a back wall extending between the top surface and the bottom surface. The magnet mounting recess wall is mounted to the top surface. The magnet mounting recess wall is configured to accommodate a magnet of a sliding head of a sample processing system. At least a portion of the bottom surface is curved in a first direction from the front wall to the back wall and is concave relative to the top surface.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: December 13, 2016
    Assignee: Gilson, Inc.
    Inventors: Kevin Fawcett, Gregory J. Robinson, David John Guckenberger, Scott Berry, David J. Beebe
  • Publication number: 20160346524
    Abstract: A device is provided for the administration of a compound in a body. The device includes a capsule having a reservoir therein for receiving the compound therein and a delivery instrument for positioning the capsule within the body. The delivery instrument includes a barrel having an interior adapted to receive the capsule therein and a dispersal element interacting with the barrel to selectively expel the capsule therefrom and into the body. A diffusion regulator communicates with the reservoir and controls the diffusion of the compound from the reservoir into the body. A retention structure projects from capsule and is configured to retain the capsule at a desired location within the body. Multiple devices may be used in conjunction to provide a multiplexed point source to administer multiple compounds simultaneously in vivo.
    Type: Application
    Filed: June 1, 2015
    Publication date: December 1, 2016
    Inventors: David J. Beebe, Mark E. Burkard, Jay W. Warrick, David J. Guckenberger, Lee G. Wilke
  • Patent number: 9459189
    Abstract: A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a second zone for receiving an isolation fluid therein. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone and a second position adjacent the isolation zone. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the isolation zone in response to the force moving from the first position to the second position.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: October 4, 2016
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Scott M. Berry, David J. Guckenberger, Ben P. Casavant
  • Publication number: 20160202157
    Abstract: An adapter for a sliding head of a sample processing system is provided that includes a plate and a magnet mounting recess wall. The plate includes a top surface, a bottom surface, a front wall extending between the top surface and the bottom surface, and a back wall extending between the top surface and the bottom surface. The magnet mounting recess wall is mounted to the top surface. The magnet mounting recess wall is configured to accommodate a magnet of a sliding head of a sample processing system. At least a portion of the bottom surface is curved in a first direction from the front wall to the back wall and is concave relative to the top surface.
    Type: Application
    Filed: January 13, 2015
    Publication date: July 14, 2016
    Inventors: Kevin Fawcett, Gregory J. Robinson, David John Guckenberger, Scott Berry, David J. Beebe
  • Patent number: 9157550
    Abstract: Microfluidic systems and methods. A microfluidic device for in vitro fertilization comprises a substrate and a plurality of microchannels disposed in the substrate, including an inlet of at least two of the plurality of microchannels arranged on the substrate to align with a fluid-handling device. Another microfluidic system for assaying a plurality of cells comprises a substrate and a plurality of microfluidic channels comprising a source channel, a sink channel, and a cell chamber. An insert for a microfluidic system comprises a substrate configured to be inserted into a dish and a plurality of microscale wells disposed in the substrate. A microfluidic channel comprises a substrate and at least one microchannel having an open inlet, an open outlet, a channel, and an opening in the substrate disposed over a portion of the channel.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: October 13, 2015
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Matthew B. Wheeler, Dongshin Kim, David J. Beebe