Patents by Inventor David J. Carini

David J. Carini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-cycloalkylglycines as HIV protease inhibitors
    Publication number: 20040142878
    Abstract: This invention relates generally to N-cycloalkylglycines of the Formula (I): 1
    Type: Application
    Filed: October 30, 2003
    Publication date: July 22, 2004
    Inventor: David J. Carini
  • Semicarbazides and their uses
    Publication number: 20020091127
    Abstract: The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): 1
    Type: Application
    Filed: December 7, 2001
    Publication date: July 11, 2002
    Inventor: David J. Carini
  • Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
    Patent number: 6413957
    Abstract: The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: July 2, 2002
    Assignee: Bristol-Myers Suibb Pharma Company
    Inventors: David A. Nugiel, David J. Carini, Susan V. Di Meo, Eddy W. Yue
  • Indeno [1,2-c] pyrazol-4-ones and their uses
    Patent number: 6407103
    Abstract: The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: June 18, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: David A. Nugiel, David J. Carini, Susan V. Di Meo, Eddy W. Yue
  • Indeno [1,2-c]pyrazol-4-ones and their uses
    Publication number: 20010027195
    Abstract: The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): 1
    Type: Application
    Filed: December 6, 2000
    Publication date: October 4, 2001
    Inventors: David A. Nugiel, David J. Carini, Susan V. DiMeo, Eddy W. Yue
  • Acylsemicarbazides and their uses
    Patent number: 6291504
    Abstract: The present invention relates to the synthesis of a new lass of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: September 18, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: David A. Nugiel, David J. Carini, Susan V. Di Meo, Anup P. Vidwans, Eddy W. Yue
  • Angiotensin II receptor blocking imidazoles
    Patent number: 5354867
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: April 15, 1993
    Date of Patent: October 11, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Pancras C. Wong
  • Substituted pyrazole angiotensin II antagonists
    Patent number: 5315013
    Abstract: Substituted pyrazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: May 24, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Gregory J. Wells
  • Radioiodinated angiotensin receptor antagonists
    Patent number: 5264581
    Abstract: Disclosed are novel radioiodinated imidazole Angiotensin II antagonists that are useful radioligands. An illustrative compound of this novel class of compounds is 4-chloro-N-[2-[4-hydroxy-3-(iodo-125I)phenyl]ethyl]-2-propyl-1-[[2'-(tetra zol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxamide.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: November 23, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: David J. Carini
  • Fused aryl substituted imidazole angiotensin II receptor inhibitors
    Patent number: 5254546
    Abstract: Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: October 19, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Robert J. Ardecky, David J. Carini, John Jonas V. Duncia, Pancras C. Wong
  • Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
    Patent number: 5210079
    Abstract: Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxy methyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imi dazole and pharmaceutically acceptable salts thereof are useful for treating chronic renal failure, mediated by angiotensin-II.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: May 11, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Pancras C. Wong
  • Substituted 1,2,3 triazole angiotensin II antagonists
    Patent number: 5189048
    Abstract: This invention includes substituted pyrroles, pyrazoles and triazoles, processes for their preparation, pharmaceutical compositions containing them, and their use as antihypertensive agents, and as a treatment for congestive heart failure in mammals. The heterocyclic compounds of the invention have the structural formula (I) ##STR1## or pharmaceutically suitable salts thereof.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: February 23, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Greogry J. Wells
  • Method and composition for preventing NSAID-induced renal failure
    Patent number: 5155118
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: October 13, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia, Pancras C. B. Wong
  • Treatment of hypertension with angiotensin II blocking imidazoles
    Patent number: 5153197
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: October 6, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia
  • 4-Alkylimidazole derivatives and anti-hypertensive use thereof
    Patent number: 5137902
    Abstract: Angiotensin II antagonist antihypertensive compounds such as ##STR1## where R.sup.2 is --CHO or --COOH and R.sup.1 is ethyl have outstanding orally potency.
    Type: Grant
    Filed: February 4, 1991
    Date of Patent: August 11, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: David J. Carini
  • Angiotensin II receptor blocking imidazoles
    Patent number: 5138069
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: December 6, 1988
    Date of Patent: August 11, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia, Pancras C. B. Wong
  • Treatment of congestive heart failure with angiotensin 11 receptor blocking imidazoles
    Patent number: 5128355
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: July 7, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia
  • Substituted 1,2,4-triazole angiotensin II antagonists
    Patent number: 5093346
    Abstract: Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
    Type: Grant
    Filed: March 8, 1991
    Date of Patent: March 3, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia, Gregory J. Wells
  • Substituted 1,2,3-triazole angiotensin II antagonists
    Patent number: 5081127
    Abstract: Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
    Type: Grant
    Filed: March 26, 1990
    Date of Patent: January 14, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Gregory J. Wells
  • Treatment of hypertension with 1,2,4-angiotensin II antagonists
    Patent number: 5015651
    Abstract: Substituted pyrroles, pyrazoles and traizoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
    Type: Grant
    Filed: December 6, 1988
    Date of Patent: May 14, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John J. V. Duncia, Gregory J. Wells