Abstract: The present disclosure provides a low-profile system and methods for delivering a microneedle array. The delivery system includes a housing that may be secured to and temporarily worn on a patient's skin. A carrier assembly coupled to a microneedle array is received in the housing proximate an applicator device. The carrier assembly is at least releasably secured to the housing and it is typically not attached or otherwise fixed to any portion of the applicator device.

Abstract: The present disclosure provides a low-profile system and methods for delivering a microneedle array. The delivery system includes a housing that may be secured to and temporarily worn on a patient's skin. A carrier assembly coupled to a microneedle array is received in the housing proximate an applicator device. The carrier assembly is at least releasably secured to the housing and it is typically not attached or otherwise fixed to any portion of the applicator device.

Abstract: The present disclosure provides low-profile systems and methods for delivering a microneedle array. A delivery system includes a housing that may be secured to and temporarily worn on a patient's skin. A carrier assembly coupled to a microneedle array is received in the housing proximate a stored energy device. The stored energy device can be designed to store a predetermined amount of potential energy that is greater or substantially greater than the energy necessary to release said energy. As the stored energy device is potentially capable of releasing substantially more energy than is required to cause the release, the amount of normal force applied to the skin can be minimized while sufficient application velocity is still generated.

Abstract: Preformed malleable dental crowns with a side-generic external shape with a plane of symmetry in the facial-lingual direction and/or a plane of symmetry in the mesial-distal direction. The preformed dental crowns also include a hardenable composition that has sufficient malleability such that the side-generic external shape can be formed into, e.g., a left-side specific or right-side specific adjusted external shape. Methods of the invention may include fitting the dental crowns by adjusting or forming them to provide side-specific features, followed by hardening of the hardenable composition.

Abstract: The invention features integrated membrane assemblies for selectively transferring a constituent to or from a fluid. The assemblies include two or more flat sheet membrane elements and at least one common manifold connected to the interior regions of the membrane elements.

Abstract: Apparatus controllably breaks hollow spheres stored in an enclosure. A first screen is disposed within the enclosure on a screen support. The screen has holes that are no larger in mesh size than the smallest hollow spheres. The screen support provides support to the first screen and has void areas to allow debris from broken spheres to pass through. An impeller is in contact with the first screen such that movement of the impeller across the first screen breaks the hollow spheres in contact with the first screen.