Patents by Inventor David J. Cole
David J. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240123307Abstract: A golf club has a first shaft coupled to a club head, a second shaft configured to slidably engage a portion of the first shaft, a grip coupled to the second shaft, and an adjustable length shaft assembly received by the second shaft and configured to allow a portion of the first shaft to slide in relation to the second shaft in a first configuration, and to restrict a portion of the first shaft from sliding in relation to the second shaft in a second configuration. The grip is restricted from rotation about the first shaft or the second shaft as the first shaft slides in relation to the second shaft.Type: ApplicationFiled: December 20, 2023Publication date: April 18, 2024Inventors: Travis D. Milleman, Anthony D. Serrano, Eric V. Cole, David S. Kultala, David L. Petersen, Les J. Bryant, Richard D. MacMillan, Rick Solesbee, John A. Solheim, Evan R. Greer
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Patent number: 11960683Abstract: A display system for sensing a finger of a user applied to the display system includes a display panel; a sensor for sensing the finger; a sensing light source configured to emit a first light having a first wavelength W1; and a reflective polarizer disposed between the display panel and the sensor. For a substantially normally incident light, an optical transmittance of the reflective polarizer versus wavelength for a first polarization state has a band edge such that for a first wavelength range extending from a smaller wavelength L1 to a greater wavelength L2 and including W1, where 30 nm?L2?L1?50 nm and L1 is greater than and within about 20 nm of a wavelength L3 corresponding to an optical transmittance of about 50% along the band edge, the optical transmittance has an average of greater than about 75%.Type: GrantFiled: May 4, 2021Date of Patent: April 16, 2024Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: Bharat R. Acharya, Robert D. Taylor, Joseph P. Attard, Benjamin J. Forsythe, David T. Yust, Matthew E. Sousa, Jason S. Petaja, Anthony M. Renstrom, William Blake Kolb, Matthew S. Cole, Matthew S. Stay, Matthew R. D. Smith, Jeremy O. Swanson, Tri D. Pham, David A. Rosen, Qunyi Chen, Lisa A. DeNicola, Quinn D. Sanford, Carl A. Stover, Lin Zhao, Gilles J. Benoit
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Publication number: 20240107113Abstract: Various implementations disclosed herein include devices, systems, and methods that provide video content (e.g., a TV show, a recorded sporting event, a movie, a 3D video, etc.) within a 3D environment using parameters selected based on one or more contextual factors. Such contextual factors may be determined based on an attribute of the content (e.g., its intended purpose or viewing environment), the user (e.g., the user's visual quality, interpupillary distance, etc.), the 3D environment (e.g., current lighting conditions, spatial considerations, etc.), or other context attributes.Type: ApplicationFiled: September 15, 2023Publication date: March 28, 2024Inventors: Danvin Ruangchan, David M. Cole, Joshua J. Taylor, Christopher T. Eubank, Samir Gehani, Travis W. Brown, Shai Messingher Lang
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Publication number: 20160185280Abstract: A hands free bicycle signaling system is provided which allows a cyclist to communicate with drivers and others around him/her to increase the cyclist's and the others' safety. It includes helmet mountable safety related outputs, a power source, and a control unit. A safety related output can be voice activated.Type: ApplicationFiled: December 11, 2015Publication date: June 30, 2016Inventors: David J. Coles, Michael R. Vindler
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Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
Patent number: 8569521Abstract: This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substituents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.Type: GrantFiled: October 6, 2011Date of Patent: October 29, 2013Assignee: Merck Sharp & Dohme Corp.Inventors: Theodros Asberom, Thomas A. Bara, Chad E. Bennett, Duane A. Burnett, Mary Anne Caplen, John W. Clader, David J. Cole, Martin S. Domalski, Hubert B. Josien, Chad E. Knutson, Hongmei Li, Mark D. McBriar, Dmitri A. Pissarnitski, Li Qiang, Murali Rajagopalan, Thavalakulamgara K. Sasikumar, Jing Su, Haiqun Tang, Wen-Lian Wu, Ruo Xu, Zhiqiang Zhao -
Publication number: 20130234431Abstract: A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.Type: ApplicationFiled: April 19, 2013Publication date: September 12, 2013Inventors: Michael E. Beard, David J. Cole, Christopher S. Caldwell, Michael G. B. Foley
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Patent number: 8424919Abstract: A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.Type: GrantFiled: January 24, 2012Date of Patent: April 23, 2013Assignee: RTI Energy Systems, Inc.Inventors: Michael E. Beard, David J. Cole, Christopher S. Caldwell, Michael B. Foley
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BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS
Publication number: 20120264736Abstract: This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substituents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.Type: ApplicationFiled: October 6, 2011Publication date: October 18, 2012Applicant: Schering CorporationInventors: Theodros Asberom, Thomas A. Bara, Chad E. Bennett, Duane A. Burnett, Mary Ann Caplen, John W. Clader, David J. Cole, Martin S. Domalski, Hubert B. Josien, Chad E. Knutson, Hongmei Li, Mark D. McBriar, Dmitri A. Pissarnitski, Li Qiang, Murali Rajagopalan, Thavalakulamgara K. Sasikumar, Jing Su, Haiqun Tang, Wen-Lian Wu, Ruo Xu, Zhiqiang Zhao -
Publication number: 20120119490Abstract: A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.Type: ApplicationFiled: January 24, 2012Publication date: May 17, 2012Inventors: Michael E. Beard, David J. Cole, Christopher S. Caldwell, Michael B. Foley
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Patent number: 8100437Abstract: A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.Type: GrantFiled: April 19, 2010Date of Patent: January 24, 2012Inventors: Michael E. Beard, David J. Cole, Christopher S. Caldwell, Michael B. Foley
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Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
Patent number: 8067621Abstract: This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substitutents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.Type: GrantFiled: January 18, 2007Date of Patent: November 29, 2011Assignee: Schering CorporationInventors: Theodros Asberom, Thomas A. Bara, Chad E. Bennett, Duane A. Burnett, Mary Ann Caplen, John W. Clader, David J. Cole, Martin S. Domalski, Hubert B. Josien, Chad E. Knutson, Hongmei Li, Mark D. McBriar, Dmitri A. Pissarnitski, Li Qiang, Murali Rajagopalan, Thavalakulamgara K. Sasikumar, Jing Su, Haiqun Tang, Wen-Lian Wu, Ruo Xu, Zhiqiang Zhao -
Publication number: 20110201012Abstract: Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx, the overexpression of a nucleic acid of KS1/4, or the overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx in non-primary tissue being correlated with metastases of epithelial cancers.Type: ApplicationFiled: October 19, 2010Publication date: August 18, 2011Inventors: MICHAEL MITAS, David J. Cole, William E. Gillanders, Michael Wallace
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Enhanced detection of RNA using a panel of truncated gene-specific primers for reverse transcription
Patent number: 7981616Abstract: The present invention provides truncated gene-specific primers in panels that can be used during the reverse transcription step of RT-PCR to increase signal detection of cancer gene markers in a tissue sample. Also provided are forward and reverse primers for RT-PCR. Methods of using the primers are also provided.Type: GrantFiled: February 25, 2005Date of Patent: July 19, 2011Assignee: MUSC Foundation for Research DevelopmentInventors: Michael Mitas, David J. Cole, William E. Gillanders, Kaidi Mikhitarian -
Patent number: 7824857Abstract: Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx, the overexpression of a nucleic acid of KS1/4, or the overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx in non-primary tissue being correlated with metastases of epithelial cancers.Type: GrantFiled: December 2, 2004Date of Patent: November 2, 2010Assignee: MUSC Foundation for Research DevelopmentInventors: Michael Mitas, David J. Cole, William E. Gillanders, Michael Wallace
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Publication number: 20100253076Abstract: A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.Type: ApplicationFiled: April 19, 2010Publication date: October 7, 2010Inventors: Michael E. Beard, David J. Cole, Christopher S. Caldwell, Michael B. Foley
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Patent number: 7699354Abstract: A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.Type: GrantFiled: April 28, 2006Date of Patent: April 20, 2010Inventors: Michael E. Beard, David J. Cole, Christopher S. Caldwell, Michael B. Foley
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Publication number: 20080241849Abstract: Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx, the overexpression of a nucleic acid of KS1/4, or the overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx in non-primary tissue being correlated with metastases of epithelial cancers.Type: ApplicationFiled: May 13, 2008Publication date: October 2, 2008Inventors: Michael Mitas, David J. Cole, William E. Gillanders, Michael Wallace
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Enhanced Detection of Rna Using a Panel of Truncated Gene-Specific Primers for Reverse Transcription
Publication number: 20080233563Abstract: The present invention provides truncated gene-specific primers in panels that can be used during the reverse transcription step of RT-PCR to increase signal detection of cancer gene markers in a tissue sample. Also provided are forward and reverse primers for RT-PCR. Methods of using the primers are also provided.Type: ApplicationFiled: February 25, 2005Publication date: September 25, 2008Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENTInventors: Michael Mitas, David J. Cole, William E. Gillanders, Kaidi Mikhitarian -
Patent number: 7296583Abstract: A spray clean stage of a pretreatment system for treating a product surface having contaminants includes a tank for holding a cleaning solution to clean the product surface. A solution applicator is in fluid communication with the tank through an applicator inlet. The solution applicator is oriented to spray the solution onto the product surface thereby removing the contaminants from the product surface. A partition at least partially covers the tank and receives runoff of the solution from the product surface being sprayed with the solution. The partition is oriented to direct the runoff of solution from the product surface into the tank at a location spaced from the applicator inlet to distance the contaminants removed from the product surface from the applicator inlet.Type: GrantFiled: December 19, 2002Date of Patent: November 20, 2007Assignee: Durr Systems, Inc.Inventors: Eduardo E. Vazquez, Clive Snell, David J. Cole
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Patent number: 7241080Abstract: A pump for transferring particulate material from a source to a remote location, including a particulate chamber having open ends, check valves at the open ends, a vacuum source connected to the chamber adjacent one end, a gas source at the opposed end of the chamber and a control which alternatively connects the vacuum to the chamber to draw particulate material from the source to the chamber and connecting the gas under pressure to drive the particulate material to the remote location. In a preferred embodiment, the chamber has a cylindrical inner diameter and the source of vacuum is a venturi pump connected to a pinch valve permitting overflow of particulate material through the pinch valve and venturi pump, which is returned to the source. In one embodiment, the pinch valve surrounds an open end of the chamber permitting overflow while avoiding agglomeration of the particulate material.Type: GrantFiled: March 22, 2004Date of Patent: July 10, 2007Assignee: Durr Industries, Inc.Inventors: Joseph M. Klobucar, James L. Pakkala, Mazen Haddad, David J. Cole