Abstract: The present application provides a method to treat a glioma in a subject, such as Diffuse Intrinsic Pontine Glioma (DIPG), using at least one STAT3 inhibitor. The glioma treatable with a STAT3 inhibitor may have a mutation in a histone H3 gene, including H3F3A. For example, the glioma may have a H3K27M mutation. Suitable examples of STAT3 inhibitors include WP1066, S3I-201 and C1-C10, or a pharmaceutically acceptable salt thereof.

Abstract: Compositions that modulate the activity of signal transducer and activator of transcription-3 (STAT3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as substituted pyrazoles and are useful in treatment of diseases related to the activity of STAT3 including, for example, cancer and other diseases.

Abstract: Compositions that modulate the activity of signal transducer and activator of transcription-3 (STAT3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as substituted pyrazoles and are useful in treatment of diseases related to the activity of STAT3 including, for example, cancer and other diseases.

Abstract: Compositions that modulate the activity of signal transducer and activator of transcription-3 (STAT3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as substituted pyrazoles and are useful in treatment of diseases related to the activity of STAT3 including, for example, cancer and other diseases.

Abstract: Compositions that modulate the activity of signal transducer and activator of transcription-3 (STAT3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as substituted pyrazoles and are useful in treatment of diseases related to the activity of STAT3 including, for example, cancer and other diseases.

Abstract: A system for layup of a solar cell string on a substrate includes a robotic arm having a pickbar attached to a free end thereof. The pickbar has an elongated body with a plurality of vacuum grippers spaced along the body each for gripping an individual solar cell of the solar cell string. A vacuum source applies a vacuum through the vacuum grippers to grip the solar cells and a controller connected to the robotic arm positioned the solar cell string gripped by the pickbar on a substrate. A pair of sensor assemblies mounted on the pickbar generates signals representing positions of portions of the solar cell string and features of the substrate. The controller responds to the signals for positioning the gripped solar cell string relative to the substrate.