Abstract: A balloon for use in a body lumen comprises a first inflatable balloon segment and a second inflatable balloon segment. The balloon has at least one opening for receiving inflation fluid to inflate the balloon segments. The first balloon segment when inflated includes a surface that defines a recess to receive at least a portion of the second balloon segment. The first and second balloon segments are arranged relative to each other such that a major portion of one of the first and second balloon segments is received in the body lumen before the other of the first and second balloon segments begins to be received in the body lumen.