Patents by Inventor David J. Galas

David J. Galas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chromosome 1 gene and gene products related to alzheimer's disease
    Publication number: 20030180880
    Abstract: The present invention discloses nucleic acid molecules encoding AD4 gene products, expression vectors and host cells suitable for expressing such gene products. Also disclosed are methods for treating, preventing, and diagnosing Alzheimer's Disease.
    Type: Application
    Filed: June 24, 2002
    Publication date: September 25, 2003
    Applicant: University of Washington
    Inventors: Rudolph E. Tanzi, Gerard D. Schellenberg, Wilma Wasco, Ephrat Levy-Lahad, Thomas D. Bird, David J. Galas
  • Compositions and methods for increasing bone mineralization
    Publication number: 20030166247
    Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Application
    Filed: March 6, 2003
    Publication date: September 4, 2003
    Applicant: Darwin Discovery Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Gene expression analysis using nicking agents
    Publication number: 20030165911
    Abstract: The present invention provides methods and compositions for gene expression analyses using nicking agents.
    Type: Application
    Filed: July 15, 2002
    Publication date: September 4, 2003
    Applicant: Keck Graduate Institute
    Inventors: Jeffrey Van Ness, David J. Galas, Lori K. Van Ness
  • Methylation analysis using nicking agents
    Publication number: 20030152952
    Abstract: The present invention provides methods and compositions for nucleic acid methylation analysis using nicking agents.
    Type: Application
    Filed: July 15, 2002
    Publication date: August 14, 2003
    Applicant: Keck Graduate Institute
    Inventors: Jeffrey Van Ness, David J. Galas, Lori K. Van Ness
  • Exponential amplification of nucleic acids using nicking agents
    Publication number: 20030138800
    Abstract: The present invention provides methods and compositions for exponential amplification of nucleic acid molecules using nicking agents. In certain aspects, the amplification may be performed isothermally. This invention is useful in many areas such as disease diagnosis.
    Type: Application
    Filed: July 15, 2002
    Publication date: July 24, 2003
    Applicant: Keck Graduate Institute
    Inventors: Jeffrey Van Ness, David J. Galas, Lori K. Van Ness
  • Nucleic acid amplification using nicking agents
    Publication number: 20030104431
    Abstract: The present invention provides methods and kits for amplifying target nucleic acids (including whole genomes) using nicking agents. In certain aspects, the amplification does not require the use of any external oligonucleotide primers that are capable of annealing to a portion of the target nucleic acid. This invention is useful in many areas such as genetic disease diagnoses, forensic analyses and palcoarcheological studies.
    Type: Application
    Filed: July 15, 2002
    Publication date: June 5, 2003
    Applicant: Keck Graduate Institute
    Inventors: Jeffrey Van Ness, David J. Galas, Lori K. Van Ness
  • Exponential nucleic acid amplification using nicking endonucleases
    Publication number: 20030082590
    Abstract: The present invention provides methods and composition for exponential nucleic acid amplification using nicking agents. The invention is useful in many areas such as disease diagnosis, genetic variation detection and pre-mRNA alternative splicing analysis.
    Type: Application
    Filed: July 15, 2002
    Publication date: May 1, 2003
    Applicant: Keck Graduate Institute
    Inventors: Jeffrey Van Ness, David J. Galas, Lori K. Van Ness
  • Compositions and methods for increasing bone mineralization
    Patent number: 6495736
    Abstract: A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: December 17, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Polypeptides associated with alterations in bone density
    Patent number: 6489445
    Abstract: Compositions and methods for increasing bone density using antibodies directed to a novel class or family human of TGF-&bgr; binding proteins are disclosed. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis. The disclosed compositions include polypeptides, and their encoding polynucleotides, which specifically bind to at least one human bone morphogenic protein (BMP) selected from BMP-5 and BMP-6.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: December 3, 2002
    Assignee: Celltech R&D, Inc.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler
  • Chromosone 1 gene and gene products related to Alzheimer's Disease
    Patent number: 6468791
    Abstract: The present invention discloses nucleic acid molecules encoding AD4 gene products, expression vectors and host cells suitable for expressing such gene products. Also disclosed are methods for treating, preventing, and diagnosing Alzheimer's Disease.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: October 22, 2002
    Assignees: The General Hospital Corp., University of Washington
    Inventors: Rudolph E. Tanzi, Gerard D. Schellenberg, Wilma Wasco, Ephrat Levy-Lahad, Thomas D. Bird, David J. Galas
  • Nucleic acids encoding a novel family of TGF-&bgr; binding proteins from humans
    Patent number: 6395511
    Abstract: A novel human protein has been isolated which is encoded by a nucleic acid molecule comprising the polynucleotide sequence provided in SEQ ID NO:1 or a polynucleotide sequence that is completely complementary thereto. This novel protein binds to at least two members of the family of TGF-beta proteins, which are the human bone morphogenic protein-5 and human bone morphogenic protein-6.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: May 28, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Mary E. Brunkow, David J. Galas, Brian Kovacevich, John T. Mulligan, Bryan W. Paeper, Jeffrey Van Ness, David G. Winkler