Abstract: A prosthetic metatarsal implant comprising a head and a neck extending from the head. A stem having at least one anchoring aperture extending transversely therethrough extends from the neck for insertion into a metatarsal bone. Means received by the at least one anchoring aperture for anchoring the stem in the metatarsal bone.

Abstract: Methods and compositions are presented that inhibit fibril formation and/or bring about disassembly of pre-formed fibrils. Compositions include peptides with short &bgr;-strands with two faces: one that can bind to &bgr;-amyloids through hydrogen bonds, and one which blocks propagation of hydrogen bonding needed to form fibrils. Thus, short congeners of the fibril protein containing N-methyl amino acids or esters are provided for the inhibition of fibril formation and for the disassembly of pre-existing or pre-formed fibrils. Specific aspects address &bgr;-amyloid fibrils; prion mediated fibrils; Huntington protein fibrils. Methods for screening for potential fibril inhibitors and disassemblers, diagnostic analysis and treatments are provided.

Abstract: Aqueous slurries of fine coal are dewatered by a process which comprises mixing an organopolysiloxane with the slurry, separating the slurry to recover the fine coal and further drying the fine coal, if desired. The use of water-soluble organopolysiloxanes or water-emulsifiable organopolysiloxanes provides improved separating and/or improved drying of fine coal in the dewatering process that is disclosed.

Abstract: Solid substrates are provided with a cured silicone release coating by applying certain mercaptoalkyl-containing triorganosiloxane-endblocked polydiorganosiloxane fluids to the surface of the substrate and exposing the applied fluid to energetic radiation to rapidly cure and bond the fluid. For example, a mixture of benzophenone and a trimethylsiloxane-endblocked copolymer of dimethylsiloxane units and methylmercaptopropylsiloxane units, when applied to kraft paper and cured with ultraviolet light, provides premium release of aggressive acrylic adhesive from the surface of the coated paper.

Abstract: Radiation-curable compositions consisting essentially of a triorganosiloxane-endblocked polydiorganosiloxane fluid bearing a small percentage of mercaptoalkyl radicals and a curing agent comprising a 1,1'-oxy-bis-(1-methyl-1-silacyclopentene) are disclosed. When applied to a substrate and exposed to energetic radiation these compositions rapidly cured to provide a coating on the substrate that releases aggressive adhesives. Advantageously, the coating, when cured with ultraviolet light in air, is essentially free of the obnoxious odor which characterizes the analogous compositions of the art which are cured with only polymethylvinylsiloxane as a curing agent.

Abstract: Certain polydiorganosiloxane compositions bearing mercaptoalkyl radicals and vinyl radicals are disclosed which cure in the presence of radiation such as ultraviolet light. The compositions consist essentially of a mixture of a triorganosiloxane-endblocked polydiorganosiloxane fluid in which from 1 to 5 percent of the organic radicals are mercaptoalkyl radicals and a methylvinylpolysiloxane. The compositions may be applied to a substrate such as paper and exposed to radiation to prepare a coated substrate that provides premium release of aggressive acrylic adhesives.