Abstract: Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, R5, X1, X2, and n are described herein. Also provided is a method of treating an estrogen-mediated disease requiring inhibition of estrogen receptor alpha (ER-alpha), such as cancer, in a subject or inhibiting ER-alpha in a cell with the compound of formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: Embodiments include methods for interactive selection and display of project management information comprising: displaying first graphical information relating to a plurality of resources and to a project duration; receiving a signal indicating user modification of at least a portion of the displayed graphical information; calculating a revised allocation over the project duration for at least one of the plurality of resources; and displaying second graphical information based on the calculated revised allocation of resources. The signal may be generated in response to user movement or actuation of slider, graphic equalizer, and/or multi-segment bar controls. The signal may indicate modification of start/end date(s), total hours, or resource allocation over time. Second graphical information may include resource allocation as percentage of project requirement, utilization of at least one resource during a project, and/or monetary forecast.

Abstract: A novel joint prosthesis, particularly suitable as a metacarpophalangeal joint prosthesis, is disclosed comprising first and second intramedullary plugs adapted to be secured to the walls of the intramedullary canals of the two bones forming the joint, and first and second components each comprising a bearing portion and a stem slidably received in a longitudinal bore provided in each of said intramedullary plugs. Transmission of stresses to the bone-prosthesis fixation interfaces is substantially reduced as a result of the freedom of motion of the stems within these longitudinal bores. In a preferred embodiment, axial rotation of one, but only one, of said stems with respect to the intramedullary plug receiving it is prevented. Use of preferred configurations for the bearing portions of the two components provides an accurate reproduction of the movement and degrees of freedom of the natural metacarpophalangeal joint.