Patents by Inventor David J. Guckenberger
David J. Guckenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11724262Abstract: A device and method are provided to facilitate the handling of a volume of fluid. The device includes an elongated tube having an open first end and a second end. The tube defines a reservoir for receiving the volume of fluid. A stanchion has a first end received within the reservoir of the tube and a second end projecting from the open end of the elongated tube. In operation, the elongated tube is deposited in a first capsule having fluid therein. The first capsule is centrifuged such that the volume of fluid is received in a reservoir in the tube through the open end. The tube is removed from the first capsule and positioned in a second capsule such that the open end of the tube is spaced from a closed end of the second capsule. The second capsule is centrifuged such that the volume of fluid is expelled from the reservoir of the tube.Type: GrantFiled: September 25, 2020Date of Patent: August 15, 2023Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Jay W. Warrick, David J. Guckenberger, Jr.
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Publication number: 20220291213Abstract: Provided herein are devices, systems, and methods for purification of sample components. In particular, provided herein are lateral flow devices, systems, and methods that utilize flow control of sample handling.Type: ApplicationFiled: April 1, 2022Publication date: September 15, 2022Inventor: David J. Guckenberger
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Publication number: 20210255071Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.Type: ApplicationFiled: April 7, 2021Publication date: August 19, 2021Inventors: David J. Beebe, Ben P. Casavant, David J, Guckenberger, Scott M. Berry
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Patent number: 10996149Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.Type: GrantFiled: August 30, 2017Date of Patent: May 4, 2021Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Publication number: 20210016285Abstract: A device and method are provided to facilitate the handling of a volume of fluid. The device includes an elongated tube having an open first end and a second end. The tube defines a reservoir for receiving the volume of fluid. A stanchion has a first end received within the reservoir of the tube and a second end projecting from the open end of the elongated tube. In operation, the elongated tube is deposited in a first capsule having fluid therein. The first capsule is centrifuged such that the volume of fluid is received in a reservoir in the tube through the open end. The tube is removed from the first capsule and positioned in a second capsule such that the open end of the tube is spaced from a closed end of the second capsule. The second capsule is centrifuged such that the volume of fluid is expelled from the reservoir of the tube.Type: ApplicationFiled: September 25, 2020Publication date: January 21, 2021Inventors: David J. Beebe, Jay W. Warrick, David J. Guckenberger, JR.
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Patent number: 10807094Abstract: A device and method are provided to facilitate the handling of a volume or fluid. The device includes an elongated tube having an open first end and a second end. The tube defines a reservoir for receiving the volume or fluid. A stanchion has a first end received within the reservoir of the tube and a second end projecting from the open end of the elongated tube. In operation, the elongated tube is deposited in a first capsule having fluid therein. The first capsule is centrifuged such that the volume of fluid is received in a reservoir in the tube through the open end. The tube is removed from the first capsule and positioned in a second capsule such that the open end of the tube is spaced from a closed end of the second capsule. The second capsule is centrifuged such that the volume of fluid is expelled from the reservoir of the tube.Type: GrantFiled: September 27, 2016Date of Patent: October 20, 2020Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Jay W. Warrick, David J. Guckenberger, Jr.
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Patent number: 10792656Abstract: A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends. The second end of the body is configured for connection to the tip. A plunger is slidably received in the chamber at the first end of the body. The plunger is moveable in the chamber between an extended position and a discharge position wherein the fluid is urged from tip through the orifice. An air discharge arrangement is configured to allow air from the chamber to escape therefrom and to maintain the fluid in the tip in response to connection of the second end of the body to the tip.Type: GrantFiled: April 5, 2019Date of Patent: October 6, 2020Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, David J. Guckenberger, Jr.
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Publication number: 20200231961Abstract: A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a second location. A plurality of solid phase substrate are deposited at the first location and a plurality of particles are added to the plurality of solid phase substrate. A force is generated to draw the plurality of solid phase substrate from the first location to a second location. The plurality of particles causes clumps of the plurality of solid phase substrate to break apart as the plurality of solid phase substrate are moved in response to the force.Type: ApplicationFiled: February 7, 2020Publication date: July 23, 2020Inventors: David J. Beebe, David J. Guckenberger, JR., Hannah M. Pezzi
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Publication number: 20200209235Abstract: Provided herein are devices, systems, and methods for purification of sample components. In particular, provided herein are lateral flow devices, systems, and methods that utilize flow control of sample handling.Type: ApplicationFiled: June 20, 2018Publication date: July 2, 2020Inventor: David J. Guckenberger
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Patent number: 10662466Abstract: Provided herein are devices, systems, and methods for magnetic purification of sample components. In particular, provided herein are device bases, systems, and methods for manipulating magnetic particles.Type: GrantFiled: January 17, 2018Date of Patent: May 26, 2020Assignee: SALUS DISCOVERY, LLCInventors: Scott Berry, David J. Guckenberger
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Patent number: 10590409Abstract: A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a second location. A plurality of solid phase substrate are deposited at the first location and a plurality of particles are added to the plurality of solid phase substrate. A force is generated to draw the plurality of solid phase substrate from the first location to a second location. The plurality of particles causes clumps of the plurality of solid phase substrate to break apart as the plurality of solid phase substrate are moved in response to the force.Type: GrantFiled: December 6, 2016Date of Patent: March 17, 2020Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, David J. Guckenberger, Jr., Hannah M. Pezzi
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Patent number: 10441950Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.Type: GrantFiled: July 17, 2018Date of Patent: October 15, 2019Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Patent number: 10434513Abstract: A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a central region communicating with the upper surface. The central region is adapted for receiving a droplet of fluid thereon. The central region includes an outer periphery that defines a first fluid constraint configured for discouraging fluid on the central region from flowing therepast. A second fluid constraint extends about the first fluid constraint. The second fluid constraint is configured for discouraging fluid flowing therepast. A third fluid constraint extends about the second fluid constraint. The third fluid constraint configured for discouraging fluid flowing therepast.Type: GrantFiled: June 8, 2016Date of Patent: October 8, 2019Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, David J. Guckenberger, Jr., Scott M. Berry, Hannah M. Pezzi
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Patent number: 10391495Abstract: A deformable well structure for a microtiter plate and method are provided. The deformable well structure includes a sample container defining a well for receiving a sample therein. The sample received in the well has a concave meniscus. A deformation tool is engageable with the sample container and is moveable between a first disengaged position wherein the deformation tool is spaced from the sample container and a second, engaged position wherein the deformation tool engages and deforms at least a portion of the sample container such that the meniscus of the sample in the well is converted from concave to convex.Type: GrantFiled: August 22, 2016Date of Patent: August 27, 2019Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, David J. Guckenberger, Jr., Hannah M. Pezzi, Scott M. Berry
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Publication number: 20190232274Abstract: A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends. The second end of the body is configured for connection to the tip. A plunger is slidably received in the chamber at the first end of the body. The plunger is moveable in the chamber between an extended position and a discharge position wherein the fluid is urged from tip through the orifice. An air discharge arrangement is configured to allow air from the chamber to escape therefrom and to maintain the fluid in the tip in response to connection of the second end of the body to the tip.Type: ApplicationFiled: April 5, 2019Publication date: August 1, 2019Inventors: David J. Beebe, David J. Guckenberger, JR.
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Patent number: 10293336Abstract: A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends. The second end of the body is configured for connection to the tip. A plunger is slidably received in the chamber at the first end of the body. The plunger is moveable in the chamber between an extended position and a discharge position wherein the fluid is urged from tip through the orifice. An air discharge arrangement is configured to allow air from the chamber to escape therefrom and to maintain the fluid in the tip in response to connection of the second end of the body to the tip.Type: GrantFiled: June 8, 2016Date of Patent: May 21, 2019Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, David J. Guckenberger, Jr.
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Publication number: 20180318827Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.Type: ApplicationFiled: July 17, 2018Publication date: November 8, 2018Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Patent number: 10040062Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.Type: GrantFiled: January 14, 2014Date of Patent: August 7, 2018Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Publication number: 20180201984Abstract: Provided herein are devices, systems, and methods for magnetic purification of sample components. In particular, provided herein are device bases, systems, and methods for manipulating magnetic particles.Type: ApplicationFiled: January 17, 2018Publication date: July 19, 2018Inventors: Scott Berry, David J. Guckenberger
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Publication number: 20180155706Abstract: A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a second location. A plurality of solid phase substrate are deposited at the first location and a plurality of particles are added to the plurality of solid phase substrate. A force is generated to draw the plurality of solid phase substrate from the first location to a second location. The plurality of particles causes clumps of the plurality of solid phase substrate to break apart as the plurality of solid phase substrate are moved in response to the force.Type: ApplicationFiled: December 6, 2016Publication date: June 7, 2018Inventors: David J. Beebe, David J. Guckenberger, JR., Hannah M. Pezzi