Abstract: Compositions and methods for treating fibrosis using oligonucleotide-based therapies are provided. These therapies can be used to increase expression of Bone morphogenetic protein receptor type II (BMPR2) via inhibition of upstream Open Reading Frames, thereby reducing vasoconstriction, vascular remodeling, and formation of fibrosis, particularly pulmonary arterial fibrosis related in patients in need thereof.

Abstract: A bio-mass burner construction for alternate fuels at temperatures from about 1,800 degrees F. to about 2,800 degrees F. to replace oil and gas burners. The burner utilizes a first burning chamber having a falling fuel, entrained bed zone positioned above a traveling grate having a porous metallic woven belt. Primary air is directed through the porous belt to establish an oxygen-starved first burning chamber. A second burning chamber in fluid communication with the first burning chamber, but having a restricted diameter, effectively provides a hot air gas nozzle. The second burning chamber receives a superheated secondary air source from cored apertures in interfitting refractory block members which provide a refractory lining for a portion of the first burning chamber and receive heat from the first burning chamber to heat the secondary air.

Abstract: A bio-mass burner construction for alternate fuels at temperatures from about 1,800 degrees F. to about 2,800 degrees F. to replace oil and gas burners. The burner utilizes a first burning chamber having a falling fuel, entrained bed zone positioned above a traveling grate having a porous metallic woven belt. Primary air is directed through the porous belt to establish an oxygen-starved first burning chamber. A second burning chamber in fluid communication with the first burning chamber, but having a restricted diameter, effectively provides a hot air gas nozzle. The second burning chamber receives a superheated secondary air source from cored apertures in interfitting refractory block members which provide a refractory lining for a portion of the first burning chamber and receive heat from the first burning chamber to heat the secondary air.

Abstract: A bio-mass burner having a continuous feed on demand to a first combustion chamber that contains a hollow grate structure. The novel method of operation includes the use of at least one venturi tube which is in fluid communication with the hollow grate structure to establish an air flow into a second combustion chamber. Primary air to support combustion in the first chamber is supplied to the underside of the grate structure. Secondary air to support combustion in the second chamber is supplied through the hollow grate structure and then to the venturi tube in a sufficiently tortuous path through the first combustion chamber to insure that the air is superheated at the outlet of the venturi tube. A baffle arrangement in the first combustion chamber directs the fuel product toward the grate structure and assists in preventing any unburned gases from being ejected into the atmosphere.

Abstract: A bio-mass burner having a continuous feed on demand to a first combustion chamber that contains a hollow grate structure. The novel method of operation includes the use of at least one venturi tube which is in fluid communication with the hollow grate structure to establish an air flow into a second combustion chamber. Primary air to support combustion in the first chamber is supplied to the underside of the grate structure. Secondary air to support combustion in the second chamber is supplied through the hollow grate structure and then to the venturi tube in a sufficiently tortuous path through the first combustion chamber to insure that the air is superheated at the outlet of the venturi tube. A baffle arrangement in the first combustion chamber directs the fuel product toward the grate structure and assists in preventing any unburned gases from being ejected into the atmosphere.

Abstract: A bio-mass burner having a continuous feed on demand to a first combustion chamber that contains a hollow grate structure. The novel method of operation includes the use of at least one venturi tube which is in fluid communication with the hollow grate structure to establish an air flow into a second combustion chamber. Primary air to support combustion in the first chamber is supplied to the underside of the grate structure. Secondary air to support combustion in the second chamber is supplied through the hollow grate structure and then to the venturi tube in a sufficiently tortuous path through the first combustion chamber to insure that the air is superheated at the outlet of the venturi tube. A baffle arrangement in the first combustion chamber directs the fuel product toward the grate structure and assists in preventing any unburned gases from being ejected into the atmosphere.