Patents by Inventor David J. Hawksworth

David J. Hawksworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-GP73 monoclonal antibodies and methods of obtaining the same
    Patent number: 11421023
    Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: August 23, 2022
    Assignee: ABBOTT LABORATORIES
    Inventors: Bailin Tu, Robert N. Ziemann, Bryan C. Tieman, Philip M. Hemken, Carol S. Ramsay, Carolyn J. Strobel, David J. Hawksworth, Larry G. Birkenmeyer, Cheng Zhao, Susan E. Brophy, Barry L. Dowell, Anthony S. Muerhoff
  • ANTI-GP73 MONOCLONAL ANTIBODIES AND METHODS OF OBTAINING THE SAME
    Publication number: 20190315844
    Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.
    Type: Application
    Filed: April 17, 2019
    Publication date: October 17, 2019
    Inventors: Bailin Tu, Robert N. Ziemann, Bryan C. Tieman, Philip M. Hemken, Carol S. Ramsay, Carolyn J. Strobel, David J. Hawksworth, Larry G. Birkenmeyer, Cheng Zhao, Susan E. Brophy, Barry L. Dowell, Anthony S. Muerhoff
  • Anti-GP73 monoclonal antibodies and methods of obtaining the same
    Patent number: 10308709
    Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: June 4, 2019
    Assignee: Abbott Laboratories
    Inventors: Bailin Tu, Robert N. Ziemann, Bryan C. Tieman, Philip M. Hemken, Carol S. Ramsay, Carolyn J. Strobel, David J. Hawksworth, Larry G. Birkenmeyer, Cheng Zhao, Susan E. Brophy, Barry L. Dowell, Anthony S. Muerhoff
  • ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE
    Publication number: 20190162726
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: December 31, 2018
    Publication date: May 30, 2019
    Inventors: David J. Hawksworth, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Susan E. Brophy, Dinesh O. Shah, Joan D. Tyner, Robert N. Ziemann
  • Anti-antibodies and methods of use
    Patent number: 10215754
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: February 26, 2019
    Assignee: Abbott Laboratories
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Composition and method for the diagnosis and treatment of iron-related disorders
    Patent number: 9636398
    Abstract: Provided herein are antibodies and methods of using the antibodies to treat, prevent, modulate, attenuate and diagnose iron-related disorders.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: May 2, 2017
    Assignees: ABBVIE DEUTSCHLAND GMBH & CO. KG, ABBVIE INC.
    Inventors: Gangamani S. Beligere, Shamila Manoj, Elaine M. Brate, Frank C. Grenier, David J. Hawksworth, Robert N. Ziemann, Larry G. Birkenmeyer, Bernhard Mueller, Andreas Popp, Susan Brophy
  • ANTI-GP73 MONOCLONAL ANTIBODIES AND METHODS OF OBTAINING THE SAME
    Publication number: 20170096477
    Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.
    Type: Application
    Filed: October 11, 2016
    Publication date: April 6, 2017
    Inventors: Bailin Tu, Robert N. Ziemann, Bryan C. Tieman, Philip M. Hemken, Carol S. Ramsay, Carolyn J. Strobel, David J. Hawksworth, Larry G. Birkenmeyer, Cheng Zhao, Susan E. Brophy, Barry L. Dowell, Anthony S. Muerhoff
  • ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE
    Publication number: 20170023568
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: October 6, 2016
    Publication date: January 26, 2017
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Anti-antibodies and methods of use
    Patent number: 9482667
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: November 1, 2016
    Assignee: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Anti-GP73 monoclonal antibodies and methods of obtaining the same
    Patent number: 9469686
    Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 18, 2016
    Assignee: ABBOTT LABORATORIES
    Inventors: Bailin Tu, Robert N. Ziemann, Bryan C. Tieman, Philip M. Hemken, Carol S. Ramsay, Carolyn J. Strobel, David J. Hawksworth, Larry G. Birkenmeyer, Cheng Zhao, Susan E. Brophy, Barry L. Dowell, Anthony S. Muerhoff
  • ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE
    Publication number: 20150212083
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: April 14, 2015
    Publication date: July 30, 2015
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Anti-antibodies and methods of use
    Patent number: 9073984
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: July 7, 2015
    Assignee: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Antibodies that bind to mammalian NGAL and uses thereof
    Patent number: 8846036
    Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: September 30, 2014
    Assignee: Abbott Laboratories
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Robert N. Ziemann, Frank C. Grenier, Ryan F. Workman, Lowell Tyner
  • PlGF-1 assay and kits and components thereof
    Patent number: 8741287
    Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: June 3, 2014
    Assignee: Abbott Laboratories
    Inventors: Susan E. Brophy, Lianli Chi, Saul A Datwyler, David J. Hawksworth, Don M. Laird, Sharmila Manoj, Mary S. Pinkus, Dominick L. Pucci, Carol S. Ramsay, David C. Sogin, Bailin Tu, Zhiguang Yu, Robert N. Ziemann, Lowell J. Tyner
  • Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
    Patent number: 8734793
    Abstract: Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: May 27, 2014
    Assignee: Abbott Laboratories Inc.
    Inventors: Bailin Tu, Joan D. Tyner, James W. Scheffel, Michael K. White, Jeffrey M. Werneke, Robert N. Ziemann, David J. Hawksworth, Mary S. Pinkus, Robin A. Gutierrez
  • Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
    Patent number: 8349325
    Abstract: An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: January 8, 2013
    Assignee: Abbott Laboratories
    Inventors: Susan E. Brophy, Saul A. Datwyler, David J. Hawksworth, Don C. Laird, Sharmila Manoj, Dominick L. Pucci, Bryan C. Tieman, Joan Tyner, Lowell J. Tyner, legal representative, Zhiguang Yu
  • ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE
    Publication number: 20120122125
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: January 19, 2012
    Publication date: May 17, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • RECOMBINANT ANTIBODIES AGAINST HEPATITIS C VIRUS AND METHODS OF OBTAINING AND USING SAME
    Publication number: 20110263436
    Abstract: Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
    Type: Application
    Filed: November 22, 2010
    Publication date: October 27, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Bailin Tu, Joan D. Tyner, James W. Scheffel, Michael K. White, Jeffrey M. Werneke, Robert N. Ziemann, David J. Hawksworth, Mary S. Pinkus, Robin A. Gutierrez
  • Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
    Patent number: 7858752
    Abstract: Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: December 28, 2010
    Assignee: Abbott Laboratories
    Inventors: Bailin Tu, Joan D. Tyner, James W. Scheffel, Michael K. White, Jeffrey M. Werneke, Robert N. Ziemann, David J. Hawksworth, Mary S. Pinkus, Robin A. Gutierrez
  • SOLUBLE FMS-LIKE TYROSINE KINASE-1 (sFLT-1) ANTIBODY AND RELATED COMPOSITION, KIT, METHODS OF USING, AND MATERIALS AND METHOD FOR MAKING
    Publication number: 20100266575
    Abstract: An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
    Type: Application
    Filed: December 21, 2009
    Publication date: October 21, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, Saul A. Datwyler, David J. Hawksworth, Don C. Laird, Sharmila Manoj, Dominick L. Pucci, Bryan C. Tieman, Joan Tyner, Lowell J. Tyner, Zhiguang Yu