Patents by Inventor David J. Heiler

David J. Heiler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8530641
    Abstract: Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 ?m or less to provide a sterilized high salt, hyaluronic acid solution.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: September 10, 2013
    Assignee: Bausch & Lomb Incorporated
    Inventors: X. Michael Liu, David J. Heiler, Thomas Menzel, Abbie Brongo, Susan E. Burke, Karl Cummins
  • Publication number: 20120295869
    Abstract: Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 ?m or less to provide a sterilized high salt, hyaluronic acid solution.
    Type: Application
    Filed: August 1, 2012
    Publication date: November 22, 2012
    Inventors: X. Michael Liu, David J. Heiler, Thomas Menzel, Abbie Brongo, Susan E. Burke, Karl Cummins
  • Patent number: 8283463
    Abstract: A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: October 9, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventors: X. Michael Liu, David J. Heiler, Thomas Menzel, Abbie Brongo, Susan E. Burke, Karl Cummins
  • Publication number: 20110195925
    Abstract: A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
    Type: Application
    Filed: February 9, 2010
    Publication date: August 11, 2011
    Inventors: X. Michael Liu, David J. Heiler, Thomas Menzel, Abbie Brongo, Susan E. Burke, Karl Cummins
  • Patent number: 7897553
    Abstract: A polymeric biguanide composition comprising less than 18 mol % of terminal amine groups as measured by 13C NMR. The polymeric biguanide composition also is characterized by a relative increase in the molar concentration of terminal guanidine groups or terminal cyanoguanidino groups. The invention is also directed to ophthalmic compositions comprising the polymeric biguanide compositions. The polymeric biguanide compositions can be used as an antimicrobial component in an ophthalmic lens care solution, or as a preservative to in a pharmaceutical composition or other health care product.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: March 1, 2011
    Assignee: Bausch & Lomb Incorporated
    Inventor: David J. Heiler
  • Publication number: 20100086514
    Abstract: A contact lens care solution comprising: a cationic antimicrobial component having an average molecular weight (MNA), and a cationic oligomer or nitrogen/amine oligomer having a number average molecular weight (MNO) from 500 daltons to 15,000 daltons. The lens care solutions are used to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.
    Type: Application
    Filed: October 1, 2009
    Publication date: April 8, 2010
    Inventors: X. Michael Liu, David J. Heiler
  • Publication number: 20080311070
    Abstract: An ophthalmic composition comprising a polymeric biguanide composition having less than 18 mol % of terminal amine groups and 55 mol % or greater of terminal guanidine groups as measured by 13C NMR, and 0.005 w/v % to 0.04 w/v % hyaluronic acid. Alternatively, the ophthalmic composition comprises a polymeric biguanide composition comprising less than 18 mol % of terminal amine groups and 40 mol % or greater of terminal cyanoguanidino groups as measured by 13C NMR, and 0.005 w/v % to 0.04 w/v % hyaluronic acid. The compositions can be used for cleaning, disinfecting or packaging a contact lens.
    Type: Application
    Filed: June 2, 2008
    Publication date: December 18, 2008
    Inventors: Susan E. Burke, Srini Venkatesh, David J. Heiler
  • Publication number: 20080261841
    Abstract: A polymeric biguanide composition comprising less than 18 mol % of terminal amine groups as measured by 13C NMR. The polymeric biguanide composition also is characterized by a relative increase in the molar concentration of terminal guanidine groups or terminal cyanoguanidino groups. The invention is also directed to ophthalmic compositions comprising the polymeric biguanide compositions. The polymeric biguanide compositions can be used as an antimicrobial component in an ophthalmic lens care solution, or as a preservative to in a pharmaceutical composition or other health care product.
    Type: Application
    Filed: October 2, 2007
    Publication date: October 23, 2008
    Inventor: David J. Heiler
  • Publication number: 20080031772
    Abstract: A method of making a disinfecting solution that is effective at disinfecting contact lenses. The method includes the step of combining water, one or more antimicrobial agents and a reduced amount of solid content into a dissolved liquid mixture. The process results in an improved disinfection efficacy compared to a reference solution.
    Type: Application
    Filed: June 28, 2007
    Publication date: February 7, 2008
    Inventors: David J. Heiler, Pramod Kumar Gupta, Susan E. Burke, Suzanne F. Groemminger
  • Publication number: 20070148127
    Abstract: An ophthalmic treatment system comprises an ophthalmic treatment solution and a biguanide antimicrobial agent in solid form and in contact with said treatment solution such as to inhibit bacterial and/or fungal growth in said solution. The biguanide is partially or wholly terminated with an amine compound.
    Type: Application
    Filed: December 15, 2006
    Publication date: June 28, 2007
    Inventors: David J. Heiler, Joseph C. Salamone, Richard V. Smerbeck, Matthew S. Jonasse
  • Publication number: 20020182315
    Abstract: The present invention provides an optically clear, hydrophilic coating upon the surface of a non-plasma treated hydrophobic hydrogel lens by heating the lens in an aqueous solution containing a surface-protective agent. Alternately, the non-plasma treated hydrophobic hydrogel lens may be subjected to ultrasonication while immersed in an aqueous solution containing a surface-protective agent.
    Type: Application
    Filed: May 7, 2002
    Publication date: December 5, 2002
    Inventors: David J. Heiler, Lisa C. Simpson, John Denick, Suzanne F. Groemminger, Richard V. Smerbeck
  • Patent number: 6348507
    Abstract: The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone hydrogel lens by plasma treating the lens and subsequently heating the lens in an aqueous solution containing a surface-protective agent.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: February 19, 2002
    Assignee: Bausch & Lomb Incorporated
    Inventors: David J. Heiler, Suzanne F. Groemminger, John Denick, Jr., Lisa C. Simpson
  • Patent number: 6348508
    Abstract: The present invention is directed to a method of treating dry eye by instilling eyedrops of a composition containing a cationic cellulosic polymer. Such compositions have been found to alleviate the symptoms of dry eye without requiring the presence of anionic therapeutic agents. Low ionic strength solutions are particularly preferred.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: February 19, 2002
    Assignee: Bausch & Lomb Incorporated
    Inventors: John Denick, Jr., David J. Heiler, Zhenze Hu, Joseph C. Salamone, Richard V. Smerbeck
  • Patent number: 6323165
    Abstract: The invention is directed to compositions and methods used as in-the-eye and/or out-of-eye inhibitors of proteinaceous deposits on hydrophilic contact lenses. Compositions of the present invention comprise moderately charged polyquaternium polymers that selectively bind to hydrophilic contact lenses to block the binding of proteinaceous materials. Compositions of the present invention may be used in multipurpose cleaning solutions for contact lenses and can eliminate the need for special enzyme cleaners and the like for removing proteinaceous materials.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: November 27, 2001
    Assignee: Bausch & Lomb Incorporated
    Inventors: David J. Heiler, Stephen E. Maier, Susan P. Spooner
  • Patent number: 6309596
    Abstract: The present invention is directed to a biguanide-containing disinfecting solution containing a particular type of poloxamine for stabilizing a polymeric biguanide. The poloxamine surfactant comprises at least about 90 weight percent of poly(oxyethylene) and poly(oxypropylene) segments, in one or more copolymer chains, wherein the weight average molecular weight of said surfactant is from about 10,000 to about 30,000 and wherein at least about 70 weight percent of said poly(oxyethylene) and poly(oxypropylene) segments are poly(oxyethylene) segments, and wherein the HLB value is at least 27. The method of the present invention comprises cleaning and disinfecting a contact lens with the above-described solution. Products according to the present invention provide enhanced cleaning while maintaining biocidal efficacy.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: October 30, 2001
    Assignee: Bausch & Lomb Incorporated
    Inventors: Erning Xia, David J. Heiler
  • Patent number: 6153568
    Abstract: The present invention is directed to an ophthalmically safe disinfecting solution for contact lenses comprising the combination of a polymeric biguanide and a polyquaternium polymer of a substituted or unsubstituted vinylimidazole or its vinylimidazoliuum salt, which copolymer has a weight average molecular weight of 5,000 to 5,000,000. The invention is also directed to an improved method of disinfecting a contact lens.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: November 28, 2000
    Inventors: David J. McCanna, Stephen E. Maier, David J. Heiler, Susan P. Spooner, Erning Xia
  • Patent number: 6096138
    Abstract: The invention is directed to compositions and methods used as in-the-eye and/or out-of-eye inhibitors of proteinaceous deposits on hydrophilic contact lenses. Compositions of the present invention comprise moderately charged polyquaternium polymers that selectively bind to hydrophilic contact lenses to block the binding of proteinaceous materials. Compositions of the present invention may be used in multipurpose cleaning solutions for contact lenses and can eliminate the need for special enzyme cleaners and the like for removing proteinaceous materials.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: August 1, 2000
    Assignee: Bausch & Lomb Incorporated
    Inventors: David J. Heiler, Stephen E. Maier, Susan P. Spooner
  • Patent number: 5925317
    Abstract: A method and system for disinfecting contact lenses with iodine using a neutralizing solution having a first, rapid neutralizing component which completes its reaction with available iodine in less than five seconds and a second, slower neutralizing component which completes its reaction with available iodine in about 3 to 30 minutes.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: July 20, 1999
    Assignee: Bausch & Lomb Incorporated
    Inventors: Jill S. Rogalskyj, David J. Heiler, Alyce K. Dobie
  • Patent number: 5858937
    Abstract: The present invention provides non-oxidative methods for treating contact lenses and compositions for the same. The present invention includes contacting a lens with an aqueous solution comprising a phosphonic acid compound. In preferred embodiments of the invention, the subject phosphonic compounds are used in combination with antimicrobial agents for providing simultaneous disinfection and cleaning of contact lenses including the prevention or removal of protein deposits.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: January 12, 1999
    Assignee: Bausch & Lomb Incorporated
    Inventors: Wanda G. Richard, David J. Heiler
  • Patent number: 5765579
    Abstract: The present invention provides methods for treating contact lenses and compositions for the same. The present invention includes contacting a lens with an aqueous solution comprising a sulfobetaine compound represented by the formula: ##STR1## wherein: R.sub.1 is an alkyl group having from 8 to 30 carbon atoms, R.sub.2 and R.sub.3 are individually hydrogen or alkyl groups having from 1 to 4 carbon atoms, and R.sub.4 is an alkyl group having from 2 to 6 carbon atoms. In preferred embodiments of the invention, the subject compounds are used in combination with antimicrobial agents for providing simultaneous disinfection and cleaning of contact lenses.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: June 16, 1998
    Inventors: David J. Heiler, Suzanne F. Groemminger