Patents by Inventor David J. Horan
David J. Horan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160038269Abstract: Disclosed herein is an implantable prosthesis for breast augmentation or reconstruction procedures. The prosthesis comprises a biocompatible and biodegradable fabric structure comprising one or more individual yarns comprised of sericin-extracted native fibroin fibers, wherein the yarns are intertwined to produce the fabric structure. The fabric structure extends in at least a first dimension and has at least a first surface that is adapted to engage and support natural breast tissue and/or a prosthetic breast implant in a patient. Also disclosed are methods of supporting breast tissue or a breast implant in a patient by inserting the prosthesis between the skin of the patient and the breast tissue and/or implant within the patient.Type: ApplicationFiled: August 26, 2015Publication date: February 11, 2016Inventors: Gregory H. Altman, Jingsong Chen, Rebecca L. Horan, David J. Horan
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Patent number: 9089501Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: GrantFiled: December 20, 2013Date of Patent: July 28, 2015Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Rebecca Horan, David J. Horan, Jingsong Chen
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Patent number: 9066884Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: GrantFiled: July 30, 2012Date of Patent: June 30, 2015Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Patent number: 9060854Abstract: A knitted prosthetic device has at least two knitted sections, where each knitted section has at least one row of fiber. The knitted prosthetic device also has at least one intra-articular section disposed between the at least two knitted sections. In addition, the at least one intra-articular section has at least one single continuous fiber traversing the at least one intra-articular section and the at least two knitted sections, where the at least one single continuous fiber forms a plurality of traverses extending between the at least two knitted sections. In particular, embodiments may be used as ligament prostheses by anchoring each of the at least two knitted sections to a bone section of a patient. Such embodiments may be constructed from a strong polymer, preferably, but not limited to, silk, where the polymer provides ligament support but bioresorbs as load bearing responsibilities are transferred to tissue resulting from ingrowth.Type: GrantFiled: March 22, 2012Date of Patent: June 23, 2015Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Enrico Mortarino, David J. Horan
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Publication number: 20140105951Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: December 20, 2013Publication date: April 17, 2014Applicant: Allergan, Inc.Inventors: Gregory H. Altman, Rebecca Horan, David J. Horan, Jingsong Chen
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Patent number: 8685426Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: GrantFiled: April 26, 2012Date of Patent: April 1, 2014Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Jingson Chen, Rebecca L. Horan, David J. Horan
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Patent number: 8633027Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: GrantFiled: March 24, 2011Date of Patent: January 21, 2014Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Jingson Chen, Rebecca L. Horan, David J. Horan
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Patent number: 8628791Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: GrantFiled: March 24, 2011Date of Patent: January 14, 2014Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Jingson Chen, Rebecca L. Horan, David J. Horan
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Patent number: 8623398Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: GrantFiled: July 30, 2012Date of Patent: January 7, 2014Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Rebecca Horan, David J. Horan, Jingsong Chen
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Publication number: 20120294906Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 22, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120296443Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 22, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120296352Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 22, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120296351Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 22, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120289981Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 15, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120210547Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: April 26, 2012Publication date: August 23, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120179253Abstract: A knitted prosthetic device has at least two knitted sections, where each knitted section has at least one row of fiber. The knitted prosthetic device also has at least one intra-articular section disposed between the at least two knitted sections. In addition, the at least one intra-articular section has at least one single continuous fiber traversing the at least one intra-articular section and the at least two knitted sections, where the at least one single continuous fiber forms a plurality of traverses extending between the at least two knitted sections. In particular, embodiments may be used as ligament prostheses by anchoring each of the at least two knitted sections to a bone section of a patient. Such embodiments may be constructed from a strong polymer, preferably, but not limited to, silk, where the polymer provides ligament support but bioresorbs as load bearing responsibilities are transferred to tissue resulting from ingrowth.Type: ApplicationFiled: March 22, 2012Publication date: July 12, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Enrico Mortarino, David J. Horan
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Publication number: 20120179252Abstract: A knitted prosthetic device has at least two knitted sections, where each knitted section has at least one row of fiber. The knitted prosthetic device also has at least one intra-articular section disposed between the at least two knitted sections. In addition, the at least one intra-articular section has at least one single continuous fiber traversing the at least one intra-articular section and the at least two knitted sections, where the at least one single continuous fiber forms a plurality of traverses extending between the at least two knitted sections. In particular, embodiments may be used as ligament prostheses by anchoring each of the at least two knitted sections to a bone section of a patient. Such embodiments may be constructed from a strong polymer, preferably, but not limited to, silk, where the polymer provides ligament support but bioresorbs as load bearing responsibilities are transferred to tissue resulting from ingrowth.Type: ApplicationFiled: March 22, 2012Publication date: July 12, 2012Applicant: Allergan, Inc.Inventors: Gregory H. Altman, Enrico Mortarino, David J. Horan
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Patent number: 8172901Abstract: A knitted prosthetic device has at least two knitted sections, where each knitted section has at least one row of fiber. The knitted prosthetic device also has at least one intra-articular section disposed between the at least two knitted sections. In addition, the at least one intra-articular section has at least one single continuous fiber traversing the at least one intra-articular section and the at least two knitted sections, where the at least one single continuous fiber forms a plurality of traverses extending between the at least two knitted sections. In particular, embodiments may be used as ligament prostheses by anchoring each of the at least two knitted sections to a bone section of a patient. Such embodiments may be constructed from a strong polymer, preferably, but not limited to, silk, where the polymer provides ligament support but bioresorbs as load bearing responsibilities are transferred to tissue resulting from in-growth.Type: GrantFiled: March 20, 2008Date of Patent: May 8, 2012Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Enrico Mortarino, David J. Horan
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Publication number: 20110189773Abstract: The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.Type: ApplicationFiled: March 29, 2011Publication date: August 4, 2011Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, David L. Kaplan, Rebecca L. Horan, David J. Horan
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Publication number: 20110167602Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: March 24, 2011Publication date: July 14, 2011Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan