Abstract: A support rail having replaceable decorative side covers for mounting a glass panel on a window, door frame or other mounting structure. The support rail includes opposed longitudinally extending rail sections that cooperate to define an upper U-shaped channel for receiving an edge portion of a glass panel and a lower inverted U-shaped channel for receiving a portion of a mounting structure. A clamping assembly carried by the rail sections operatively connects the sections together to effect securement of the rail to the glass panel and mounting structure. A pair of decorative side covers are slidably mounted along the rail sections by means of flanges formed at the upper and lower ends of the side covers that project into grooves formed in the rail section. A pair of end plates are removably mounted on the rail sections for holding the side covers in place on the rail sections and allowing the removal thereof.