Patents by Inventor David J. Lefer
David J. Lefer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230233713Abstract: The invention is directed to a hypertension animal model, and methods of using the same to induce heart failure with preserved ejection fraction (HFpEF) responses.Type: ApplicationFiled: June 25, 2021Publication date: July 27, 2023Inventors: David J. Lefer, Thomas Sharp, Traci Goodchild
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Patent number: 11497775Abstract: This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein the method comprises ablating at least one nerve of the renal artery of the subject; and administering to the subject a therapeutically effective amount of cells.Type: GrantFiled: February 1, 2019Date of Patent: November 15, 2022Assignee: THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: David J. Lefer, David J. Polhemus
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Publication number: 20190160106Abstract: This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein the method comprises ablating at least one nerve of the renal artery of the subject; and administering to the subject a therapeutically effective amount of cells.Type: ApplicationFiled: February 1, 2019Publication date: May 30, 2019Inventors: David J. Lefer, David J. Polhemus
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Patent number: 10005801Abstract: The embodiments herein generally relates to compounds and methods for releasing H2S in a pH dependent manner. In particular, the invention provides compounds of various formulations which release H2S in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of H2S.Type: GrantFiled: March 2, 2017Date of Patent: June 26, 2018Assignees: Washington State University, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Ming Xian, Jianming Kang, David J. Lefer
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Publication number: 20170253622Abstract: The embodiments herein generally relates to compounds and methods for releasing H2S in a pH dependent manner. In particular, the invention provides compounds of various formulations which release H2S in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of H2S.Type: ApplicationFiled: March 2, 2017Publication date: September 7, 2017Inventors: Ming Xian, Jianming Kang, David J. Lefer
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Patent number: 9700578Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.Type: GrantFiled: January 5, 2015Date of Patent: July 11, 2017Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Acting through the Louisiana State University Health Sciences Center, The UAB Research Foundation, Loma Linda University, Wake Forest UniversityInventors: Mark T. Gladwin, Alan N. Schechter, David J. Lefer, Rakesh P. Patel, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Ryszard Marek Pluta, Edward H. Oldfield, Richard O. Cannon, III
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Patent number: 9675637Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.Type: GrantFiled: July 9, 2004Date of Patent: June 13, 2017Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, acting through Louisiana State University Health Sciences Center, The UAB Research Foundation, Loma Linda University, Wake Forest UniversityInventors: Mark T. Gladwin, Alan N. Schechter, David J. Lefer, Rakesh P. Patel, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Ryszard Pluta, Edward H. Oldfield, Richard O. Cannon, III
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Publication number: 20170087180Abstract: The present invention relates to sulfur compositions which are useful, for example, for treating a NO deficiency disorder, supplementing deficits in circulating nitrite, and/or improving bodily endurance or exercise performance.Type: ApplicationFiled: June 2, 2015Publication date: March 30, 2017Inventors: Anthony GIORDANO, David J. LEFER
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Patent number: 9034825Abstract: Provided are methods of using humanin and humanin analogs to treat a mammal exhibiting or at risk for insulin resistance, increase insulin sensitivity in a mammal exhibiting or at risk for insulin resistance, treat type-2 diabetes mellitus, metabolic syndrome, and neurodegeneration, treat and prevent myocardial injury, and determine longevity.Type: GrantFiled: February 21, 2014Date of Patent: May 19, 2015Assignee: Albert Einstein College of Medicine of Yeshiva UniversityInventors: Radhika Muzumdar, David J. Lefer
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Publication number: 20150125553Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.Type: ApplicationFiled: January 5, 2015Publication date: May 7, 2015Applicants: The Government of the United States of America as represented by the Secretary of the Department of, The Board of Supervisors of Louisiana State Univer and Agricultural and Mechanical College, Acting t, The UAB Research Foundation, Loma Linda University, Wake Forest UniversityInventors: Mark T. Gladwin, Alan N. Schechter, David J. Lefer, Rakesh P. Patel, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Ryszard Marek Pluta, Edward H. Oldfield, Richard O. Cannon, III
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Publication number: 20150064286Abstract: The present invention features sulfur-rich compositions and preparations thereof that are safe and effective as hydrogen sulfide prodrugs of high bioavailability. The invention also includes methods of treating pathological conditions associated with oxidative stress using sulfur-rich compositions. The invention further includes sulfur-rich compositions as antidotes and medical food for preserving and promoting general health.Type: ApplicationFiled: September 13, 2012Publication date: March 5, 2015Applicants: EMORY UNIVERSITY, NUEVAS ALTERNATIVAS NATURALES, S.A.P.I. DE C.V.Inventors: Gabriel Gojon-Romanillos, Gabriel Gojon-Zarrilla, David J. Lefer
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Patent number: 8927030Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.Type: GrantFiled: March 26, 2010Date of Patent: January 6, 2015Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Mark T. Gladwin, Alan N. Schechter, David J. Lefer, Rakesh P. Patel, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Ryszard Marek Pluta, Edward H. Oldfield, Richard O. Cannon, III
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Publication number: 20140179610Abstract: Provided are methods of using humanin and humanin analogs to treat a mammal exhibiting or at risk for insulin resistance, increase insulin sensitivity in a mammal exhibiting or at risk for insulin resistance, treat type-2 diabetes mellitus, metabolic syndrome, and neurodegeneration, treat and prevent myocardial injury, and determine longevity.Type: ApplicationFiled: February 21, 2014Publication date: June 26, 2014Applicant: Albert Einstein College of Medicine of Yeshiva UniversityInventors: Radhika Muzumdar, David J. Lefer
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Publication number: 20100247682Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.Type: ApplicationFiled: March 26, 2010Publication date: September 30, 2010Inventors: Mark T. Gladwin, Alan N. Schechter, David J. Lefer, Rakesh P. Patel, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Ryszard Marek Pluta, Edward H. Oldfield, Richard O. Cannon, III