Patents by Inventor David J. Leffell

David J. Leffell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Basal cell carcinoma tumor suppressor protein
    Patent number: 7317086
    Abstract: This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: January 8, 2008
    Assignee: United States of America as represented by the Department of Health and Human Services
    Inventors: Michael C. Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G. Zaphiropoulos, Mae R. Gailani, Susan M. Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne B. Unden, Susan A. Gilles, Kylie Negus, Ian McLeod Smyth, Carol L. Pressman, David J. Leffell, Bernard Gerrard, Alisa M. Goldstein, Brandon Wainwright, Rune C. M. Toftgard, Georgia Chenevix-Trench, Allen E. Bale
  • Basal cell carcinoma tumor suppressor gene
    Publication number: 20030171566
    Abstract: This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.
    Type: Application
    Filed: November 22, 2002
    Publication date: September 11, 2003
    Inventors: Michael Carlton Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G. Zaphiropoulos, Mae R. Gailani, Susan Mary Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne Birgitte Unden, Susan Alana Gillies, Kylie Negus, Ian McLeod Smyth, Carol Leah Pressman, David J. Leffell, Bernard Gerrard, Alisa Miriam Goldstein, Brandon Wainwright, Rune Carl Magnus Toftgard, Georgia Chenevix-Trench, Allen E. Bale
  • Basal cell carcinoma tumor supressor gene
    Patent number: 6552181
    Abstract: This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.
    Type: Grant
    Filed: May 16, 1997
    Date of Patent: April 22, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael Carlton Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G Zaphiropoulos, Mae R. Gailani, Susan Mary Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne Birgitte Unden, Susan Alana Gillies, Kylie Negus, Ian Mcleod Smyth, Carol Leah Pressman, David J. Leffell, Bernard Gerrard, Alisa Miriam Goldstein, Brandon Wainwright, Rune Carl-Magnus Toftgard, Georgia Chenevix-Trench, Allen E. Bale
  • Optical method and apparatus for detecting and measuring aging, photoaging, dermal disease and pigmentation in skin
    Patent number: 4894547
    Abstract: A method and apparatus for inducing fluorescence in human skin, in vivo, and for evaluating certain skin characteristics from the spectral intensity of induced fluorescence. The energy of a helium-cadmium laser is directed to a skin area to be evaluated by a fiberoptic element. The induced fluorescent energy having a wavelength band of interest above that of the laser wavelength, is directed to a device by a fiberoptic path for performing a spectral analysis of the fluorescent intensity. A ratio of chracteristic portions of fluorescent intensity of the skin area under test is developed and used to compare with different test subjects. The developed ratio, when taken in relation to the skin of subjects of different ages, indicates a marked difference in older subjects in comparison to that of very young subjects which correlates with long-term exposure of the skin to ultraviolet radiation.
    Type: Grant
    Filed: September 28, 1987
    Date of Patent: January 16, 1990
    Assignee: Yale University
    Inventors: David J. Leffell, Lawrence Deckelbaum