Patents by Inventor David J. Lloyd
David J. Lloyd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220025059Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.Type: ApplicationFiled: May 27, 2021Publication date: January 27, 2022Applicant: AMGEN INC.Inventors: Junming YIE, Donghui SHI, David J. LLOYD, Jinghong WANG, Glenn N. SIVITS, JR., Murielle M. VENIANT-ELLISON, Renee KOMOROWSKI, Neeraj AGRAWAL, Darren L. BATES, Brandon C. P. CLAVETTE, Ian N. FOLTZ, Shu-yin HO, Christopher MURAWSKY, Xiaoshan MIN, Zhulun WANG
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Patent number: 11046774Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.Type: GrantFiled: February 25, 2019Date of Patent: June 29, 2021Assignee: AMGEN INC.Inventors: Junming Yie, Donghui Shi, David J. Lloyd, Jinghong Wang, Glenn N. Sivits, Jr., Murielle M. Veniant-Ellison, Renee Komorowski, Neeraj Agrawal, Darren L. Bates, Brandon C. P. Clavette, Ian N. Foltz, Shu-yin Ho, Christopher Murawsky, Xiaoshan Min, Zhulun Wang
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Publication number: 20210087286Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.Type: ApplicationFiled: June 20, 2018Publication date: March 25, 2021Applicant: AMGEN INC.Inventors: Darren L. BATES, Donghui SHI, David J. LLOYD, Pavel BONDARENKO, Mark L. MICHAELS, Todd HAGER, Xiaoshan MIN, Aiko UMEDA, Irwin CHEN, Zhulun WANG
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Publication number: 20200384119Abstract: Method of treating metabolic diseases and disorders using a composition comprising a GLP-1/GIPR antigen binding protein fusion protein are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises the C-terminus of a GLP-1 analog fused to the N-terminus of the light chain variable or heavy chain variable region of an antibody or functional fragment thereof that binds GIPR, optionally with a linker in between.Type: ApplicationFiled: June 20, 2018Publication date: December 10, 2020Applicant: AMGEN INC.Inventors: Kenneth W. WALKER, Jerry Ryan HOLDER, David J. LLOYD, Shu-Chen LU, MurIelle M. VENIANT-ELLISON, Shanaka STANISLAUS
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Publication number: 20190276546Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.Type: ApplicationFiled: February 25, 2019Publication date: September 12, 2019Applicant: AMGEN INC.Inventors: Junming Yie, Donghui Shi, David J. Lloyd, Jinghong Wang, Glenn N. Sivits, JR., Murielle M. Veniant-Ellison, Renee Komorowski, Neeraj Agrawal, Darren L. Bates, Brandon C. P. Clavette, Ian N. Foltz, Shu-yin Ho, Christopher Murawsky, Xiaoshan Min, Zhulun Wang
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Patent number: 10294303Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.Type: GrantFiled: December 21, 2016Date of Patent: May 21, 2019Assignee: AMGEN INC.Inventors: Junming Yie, Donghui Shi, David J. Lloyd, Jinghong Wang, Glenn N. Sivits, Jr., Murielle M. Veniant-Ellison, Renee Komorowski, Neeraj Agrawal, Darren L. Bates, Brandon C. P. Clavette, Ian N. Foltz, Shu-yin Ho, Christopher Murawsky, Xiaoshan Min, Zhulun Wang
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Publication number: 20170275370Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.Type: ApplicationFiled: December 21, 2016Publication date: September 28, 2017Applicant: AMGEN INC.Inventors: Junming YIE, Donghui SHI, David J. LLOYD, Jinghong WANG, Glenn N. SIVITS, JR., Murielle M. VENIANT-ELLISON, Renee KOMOROWSKI, Neeraj AGRAWAL, Darren L. BATES, Brandon C. P. CLAVETTE, Ian N. FOLTZ, Shu-yin HO, Christopher MURAWSKY, Xiaoshan MIN, Zhulun WANG
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Patent number: 7762310Abstract: A method of producing a clad sheet article having superplastic properties, and the resulting clad sheet article. The method involves producing a cladding layer onto at least one rolling face of a core ingot made of a metal having superplastic properties, preferably by co-casting, to form a clad ingot and then rolling said clad ingot to produce a sheet article. The core ingot includes an element that diffuses from an interior of the ingot to a surface at superplastic forming temperatures thereby deteriorating surface properties of the ingot. The cladding layer is provided with an element (dopant) that reacts with the element of the core to reduce the ability of the element to diffuse through the cladding layer.Type: GrantFiled: April 12, 2007Date of Patent: July 27, 2010Assignee: Novelis Inc.Inventors: Michael J. Bull, David J. Lloyd, Phil Morris, Paul A. Wycliffe, Robert Bruce Wagstaff, Alok K. Gupta, Gijsbertus Langelaan
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Patent number: 6257312Abstract: A composite material having less than about 25 volume percent refractory particles in a metal matrix is concentrated to have about 37-45 volume percent refractory particles. The concentrating is accomplished by heating the composite material to melt the matrix, and then contacting the molten composite material to a porous element having an average pore size greater than that of the average particle size. A small pressure differential, on the order of about one atmosphere, is applied across the porous element, so that metal matrix material separates from the composite material and flows through the porous element. The particulate volume fraction in the composite material gradually increases. When the particulate volume fraction exceeds about 37 volume percent, the mass of composite material becomes semi-solid and freestanding. The resulting composite material may be further processed, as by forming to a useful shape or diluting with another matrix material.Type: GrantFiled: August 7, 1998Date of Patent: July 10, 2001Assignee: Alcan International LimitedInventors: Don Doutre, Gary Hay, Iljoon Jin, Peter Wales, David J. Lloyd
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Patent number: 6015528Abstract: A composite material mixture of free flowing reinforcement particles in a molten metal is solidified at a cooling rate greater than about 15.degree. C. per second between the liquidus and solidus temperatures of the matrix alloy. This high cooling rate imparts a homogeneous structure to the solid composite material. Care is taken to avoid the introduction of gas bubbles into the molten composite material while the mixture is stirred to prevent segregation of the particles. For viscous melts, an artificial surface layer such as a fiberglass blanket may be used to prevent entrapment of bubbles during pre-casting stirring. Additionally, gas bubbles are removed from the molten mixture by filtering and skimming.Type: GrantFiled: March 4, 1996Date of Patent: January 18, 2000Assignee: Alcan International LimitedInventors: Richard S. Bruski, Larry G. Hudson, Iljoon Jin, David J. Lloyd, Michael D. Skibo
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Patent number: 5913989Abstract: A process of manufacturing aluminum can body stock involving the following steps. A molten aluminum alloy is prepared, the alloy containing Mg in the range 1.1 to 1.5% by weight, Mn in the range 0.4 to 0.9% by weight, Cu in the range 0.2 to 0.4% by weight, Fe in the range 0.2 to 0.7% by weight, Si in the range 0.07 to 0.3% by weight, all other elements each less than 0.05% by weight to a maximum of 0.2% for all other elements. The alloy is cast in a continuous strip casting process to produce a slab having a thickness of at least 9 mm. The slab is rolled using at least 83% reduction to produce a re-roll strip. The re-roll strip is coiled to form a coil and the coil to cool is allowed to cool naturally. The re-roll strip is then annealed and cold rolled to a final gauge of between 0.26 and 0.4 mm, using a reduction of between 75 and 85%, with no interanneal. The resulting strip can be used as can body stock having a 45 degree earing of less than 3% and a yield strength after stoving of at least 38.Type: GrantFiled: July 8, 1996Date of Patent: June 22, 1999Assignee: Alcan International LimitedInventors: Paul Wycliffe, Ed Luce, David J. Lloyd, John Fitzsimon, Gene Burger
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Patent number: 5616189Abstract: An alloy of aluminum containing magnesium, silicon and optionally copper in amounts in percent by weight falling within one of the following ranges:(1) 0.4.ltoreq.Mg.ltoreq.0.8, 0.2.ltoreq.Si.ltoreq.0.5, 0.3.ltoreq.Cu.ltoreq.3.5;(2) 0.8.ltoreq.Mg.ltoreq.1.4, 0.2.ltoreq.Si.ltoreq.0.5, Cu.ltoreq.2.5; and(3) 0.4.ltoreq.Mg.ltoreq.1.0, 0.2.ltoreq.Si.ltoreq.1.4, Cu.ltoreq.2.0; said alloyhaving been formed into a sheet having properties suitable for automotive applications. The alloy may also contain at least one additional element selected from the group consisting of Fe in an amount of 0.4 percent by weight or less, Mn in an amount of 0.4 percent by weight or less, Zn in an amount of 0.3 percent by weight or less and a small amount of at least one other element, such as Cr, Ti, Zr and V.Type: GrantFiled: July 22, 1994Date of Patent: April 1, 1997Assignee: Alcan International LimitedInventors: Iljoon Jin, John Fitzsimon, Michael J. Bull, Pierre H. Marois, Alok K. Gupta, David J. Lloyd
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Patent number: 5588478Abstract: A high speed twin roll casting process is described in which molten metal is fed through a feeding nose into a convergent cavity formed between the walls of two rotating rolls with a meniscus of hot metal extending from the feeding nose tip in a casting zone and the metal strip formed in the casting zone is reduced in a rolling zone. According to the novel feature, the tendency of the metal strip to stick to the rolls is significantly inhibited by shrouding the hot metal meniscus with an oxygen enriched atmosphere. Also when the metal is an Al--Mg alloy, the sticking is greatly inhibited by adding to the alloy a small amount of at least one alloying element selected from nickel, lead, indium and bismuth.Type: GrantFiled: January 18, 1994Date of Patent: December 31, 1996Assignee: Alcan International LimitedInventors: Iljoon Jin, David J. Lloyd, Roland S. Timsit, Eric R. Lees
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Patent number: 5523050Abstract: A method is described for preparing a refined or reinforced eutectic or hyper-eutectic metal alloy, comprising: melting the eutectic or hyper-eutectic metal alloy, adding particles of non-metallic refractory material to the molten metal matrix, mixing together the molten metal alloy and the particles of refractory material, and casting the resulting mixture under conditions causing precipitation of at least one intermetallic phase from the molten metal matrix during solidification thereof such that the intermetallics formed during solidification wet and engulf said refractory particles. The added particles may be very small and serve only to refine the precipitating intermetallics in the alloy or they may be larger and serve as reinforcing particles in a composite with the alloy. The products obtained are also novel.Type: GrantFiled: March 15, 1993Date of Patent: June 4, 1996Assignee: Alcan International LimitedInventors: David J. Lloyd, Iljoon Jin
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Patent number: 5306362Abstract: The invention provides an aluminum alloy material consisting essentially of, by weight percent, 1% to 1.8% Cu, 0.8% to 1.4% Mg, 0.2% to 0.39% Si, 0.5% to 0.4% Fe, 0.05% to 0.40% Mn, with the balance aluminum with normal impurities. The alloy forms two precipitation phases during heat treatment and age hardening: a beta phase of Mg.sub.2 Si and an S' phase of Al.sub.2 CuMg. The alloy has improved formability without significant sacrifice of strength, and is particularly suited to be formed into automobile sheet metal parts such as hood lids, trunks lids, and fenders.Type: GrantFiled: September 23, 1992Date of Patent: April 26, 1994Assignee: Alcan International LimitedInventors: Alok K. Gupta, David J. Lloyd, Pierre H. Marois
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Patent number: 5299724Abstract: A composite material mixture of free flowing reinforcement particles in a molten metal is solidified at a cooling rate greater than about 15.degree. C. per second between the liquidus and solidus temperatures of the matrix alloy. This high cooling rate imparts a homogeneous structure to the solid composite material. Care is taken to avoid the introduction of gas bubbles into the molten composite material while the mixture is stirred to prevent segregation of the particles. For viscous melts, an artificial surface layer such as a fiberglass blanket may be used to prevent entrapment of bubbles during pre-casting stirring. Additionally, gas bubbles are removed from the molten mixture by filtering and skimming.Type: GrantFiled: July 13, 1990Date of Patent: April 5, 1994Assignee: Alcan International LimitedInventors: Richard S. Bruski, Larry G. Hudson, Iljoon Jin, David J. Lloyd, Michael D. Skibo
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Patent number: 5255433Abstract: Engine block cylinder liners are formed from high melting temperature aluminum alloy composites. A cast composite is first formed from a high melting temperature aluminum alloy, e.g. Al-Mn, Al-Cr, Al-Ni, Al-Fe or Al-Cr-Zr, and refractory particles, e.g. alumina. This composite is then extruded into a tubular sleeve. If desired, a long tube may be extruded which is then cut into desired lengths. These new cylinder liners have the following desirable properties: high melting temperature, good strength at the service temperature, higher thermal conductivity than cast iron, good wear resistance and good corrosion resistance.Type: GrantFiled: April 3, 1992Date of Patent: October 26, 1993Assignee: Alcan International LimitedInventors: Iljoon Jin, Paul W. Jeffrey, David J. Lloyd, Sergio Gallo
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Patent number: 5246057Abstract: A method for preparing a composite material comprises the steps of providing a first mixture of a molten aluminum-base matrix alloy having at least about 4 percent by weight magnesium, and a mass of discontinuous reinforcing particles that are not soluble in the molten matrix alloy, and mixing the first mixture to wet the matrix alloy to the particles and to distribute the particles throughout the volume of the molten matrix alloy. The first matrix alloy is diluted to reduce the magnesium content of the mixture to less than about 4 percent by weight magnesium, to produce a second mixture, and the second mixture is cast. The second mixture has at least about 5 volume percent particles, and preferably has about 5-25 volume percent particles.Type: GrantFiled: February 21, 1992Date of Patent: September 21, 1993Assignee: Alcan International Ltd.Inventors: Inge L. H. Hansson, David J. Lloyd, Iljoon Jin, Michael D. Skibo
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Patent number: 5028392Abstract: A metal matrix composite material containing discontinuous particles in a metallic matrix is prepared by forming a mixture of the molten alloy and the particles in a closed reactor, removing oxygen from the interior of the reactor, statically pressurizing the interior of the reactor with nitrogen gas, mixing the mixture of the molten alloy and particles in the presence of the static nitrogen gas to wet the molten matrix to the particles, and evacuating the interior of the reactor in a stepwise manner. The nitrogen gas aids in wetting the metallic alloy to the particles by forming aluminum nitride at the particle-molten matrix interface, so that a lower contact angle of the alloy to the particle results. Oxygen that may be present in the sealed reactor is gettered by the aluminum, and the nitrogen is removed by stepwise evacuation, thereby minimizing the introduction of gas into, and retention of gas within, the melt.Type: GrantFiled: June 14, 1990Date of Patent: July 2, 1991Assignee: Alcan International Ltd.Inventors: David J. Lloyd, Alan D. McLeod, Philip L. Morris, Iljoon Jin
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Patent number: 4929421Abstract: A new family of medium and high strength, thermally stable aluminum based alloys are described having the following composition: 0.4 to 1.2% by weight chromium, 0.3 to 0.8% by weight zirconium, 1.5 to 2.5% by weight manganese, 0 to 2.0% by weight magnesium and the balance essentially aluminum. These alloys can be produced on a twin-roll caster preferably at a thickness of no more than 4 mm and a casting temperature of at least 820.degree. C.Type: GrantFiled: August 15, 1988Date of Patent: May 29, 1990Assignee: Alcan International LimitedInventors: Iljoon Jin, David J. Lloyd