Patents by Inventor David J. Madar

David J. Madar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS
    Publication number: 20090054402
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
    Type: Application
    Filed: April 16, 2008
    Publication date: February 26, 2009
    Applicant: Abbott Laboratories
    Inventors: Xilu Wang, Xiaohong Song, Steven W. Elmore, Milan Bruncko, David J. Madar, Andrew J. Souers, Lisa A. Hasvold, Le Wang, Zhi-Fu Tao, Aaron R. Kunzer
  • TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
    Publication number: 20090054426
    Abstract: A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-?-hydroxysteroid dehydrogenase Type 1 enzyme activity.
    Type: Application
    Filed: August 21, 2008
    Publication date: February 26, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: R. Scott Bitner, Kaitlin E. Browman, Michael E. Brune, Yixian Chen, Jurgen Dinges, Karla Drescher, Peer Jacobson, Hwan-soo Jae, Ravi Kurukulasuriya, James T. Link, David J. Madar, Jyoti R. Patel, Marina A. Pliushchev, Jeffrey J. Rohde, Lynne E. Rueter, Qi Shuai, Bryan K. Sorensen, Jiahong Wang, Karsten M. Wicke, Martin Winn, Dariusz Wodka, Vince Yeh, Hong Yong
  • Inhibitors of the 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Enzyme
    Publication number: 20080312214
    Abstract: Methods for treating a mammal suffering from glucocorticoid-related diseases and conditions, comprising administering to the mammal an effective amount of a selective inhibitor of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme activity, wherein the inhibitor is a compound of formula (I): or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Methods of inhibiting 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. Methods of treating neuronal degeneration, dysfunction, acute psychosis, anxiety, dementia, depression, non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
    Type: Application
    Filed: August 25, 2008
    Publication date: December 18, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Vince S. Yeh, Ravi Kurukulasuriya, David J. Madar, James T. Link
  • Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
    Patent number: 7435833
    Abstract: A compound of formula (I): or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Methods of inhibiting 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. Methods of treating non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: October 14, 2008
    Assignee: Abbott Laboratories
    Inventors: Vince S. Yeh, Ravi Kurukulasuriya, David J. Madar, James T. Link
  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Patent number: 7262207
    Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: August 28, 2007
    Assignee: Abbott Laboratories
    Inventors: David J. Madar, Stevan W. Djuric, Melissa J. Michmerhuizen, Hana A. Kopecka, Xiaofeng Li, Kenton L. Longenecker, Zhonghua Pei, Daisy Pireh, Hing L. Sham, Kent D. Stewart, Bruce G. Szczepankiewicz, Paul E. Wiedeman, Hong Yong
  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Patent number: 7238724
    Abstract: The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Grant
    Filed: January 13, 2005
    Date of Patent: July 3, 2007
    Assignee: Abbott Laboratories
    Inventors: David J. Madar, Stevan W. Djuric, Melissa J. Michmerhuizen, Hana A. Kopecka, Xiaofeng Li, Kenton L. Longenecker, Zhonghua Pei, Daisy Pireh, Hing L. Sham, Kent D. Stewart, Bruce G. Szczepankiewicz, Paul E. Wiedeman, Hong Yong
  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Publication number: 20040259843
    Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: February 27, 2004
    Publication date: December 23, 2004
    Inventors: David J. Madar, Stevan W. Djuric, Melissa J. Michmerhuizen, Hana A. Kopecka, Xiaofeng Li, Kenton L. Longenecker, Zhonghua Pei, Daisy Pireh, Hing L. Sham, Kent D. Stewart, Bruce G. Szczepankiewicz, Paul E. Wiedeman, Hong Yong
  • Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
    Publication number: 20040121964
    Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
    Type: Application
    Filed: September 11, 2003
    Publication date: June 24, 2004
    Inventors: David J. Madar, Stevan W. Djuric, Melissa J. Feenstra, Hana A. Kopecka, Xiaofeng Li, Kenton L. Longenecker, ZhongHua Pei, Daisy Pireh, Hing L. Sham, Kent D. Stewart, Bruce G. Szczepankiewicz, Paul E. Wiedeman, Hong Yong
  • Oxazolidinone chemotherapeutic agents
    Publication number: 20020115669
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: August 29, 2001
    Publication date: August 22, 2002
    Inventors: Paul E. Wiedeman, Steven W. Djuric, Marina Pilushchev, Richard J. Sciotti, David J. Madar, Hana Kopecka
  • Oxazolidinone antibacterial agents
    Publication number: 20020091107
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: September 7, 2001
    Publication date: July 11, 2002
    Inventors: David J. Madar, Daisy Pireh, Hana Kopecka, Stevan W. Djuric, Paul E. Wiedeman
  • AZOLE INHIBITORS OF CYTOKINE PRODUCTION
    Publication number: 20010044445
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: April 8, 1999
    Publication date: November 22, 2001
    Inventors: NWE Y. BAMAUNG, ANWER BASHA, STEVAN W. DJURIC, EARL J. GUBBINS, JAY R. LULY, NOAH P. TU, DAVID J. MADAR, USHA WARRIOR, PAUL E. WIEDEMAN, XUN ZHOU, RICHARD J. SCIOTTI, FRANK L. WAGENAAR