Patents by Inventor David J. McConkey

David J. McConkey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for anti-EGFR treatment
    Patent number: 8841273
    Abstract: In some embodiments, the present invention provides methods for enhancing the sensitivity of cancer cells to anti-EGFR treatment, wherein the method comprises the introduction of a miR-200 miRNA to the cancer cells. In other embodiments, the present invention provides methods for treating cancer by exposing the cancer cells to an anti-EGFR composition after the above-mentioned enhancement step. In other embodiments, the present invention provides methods for assessing and enhancing the sensitivity of cancer cells to anti-EGFR treatment. In various other embodiments, the present invention provides compositions and expression vectors for practicing the afore-mentioned methods.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: September 23, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Liana Adam, Colin P. Dinney, David J. McConkey
  • Laser scanning cytometry mediated analysis of therapeutic efficacy in tumors
    Patent number: 8614054
    Abstract: This invention describes the use of a laser scanning device, for example a laser scanning CYTOMETRY (LSC), with a double-fluorescent labeling technique as a quantitative method that can be used to objectively and accurately measure endothelial cell death, endothelial tumor cell death and blood vessel density of tumor tissue. These parameters can be used as markers of efficacy in tumors treated with anti-angiogenic or traditional therapies and can distinguish patients who respond to these drugs from those who do not.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: December 24, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventors: Darren W. Davis, David J McConkey
  • METHODS AND COMPOSITIONS FOR ANTI-EGFR TREATMENT
    Publication number: 20130018088
    Abstract: In some embodiments, the present invention provides methods for enhancing the sensitivity of cancer cells to anti-EGFR treatment, wherein the method comprises the introduction of a miR-200 miRNA to the cancer cells. In other embodiments, the present invention provides methods for treating cancer by exposing the cancer cells to an anti-EGFR composition after the above-mentioned enhancement step. In other embodiments, the present invention provides methods for assessing and enhancing the sensitivity of cancer cells to anti-EGFR treatment. In various other embodiments, the present invention provides compositions and expression vectors for practicing the afore-mentioned methods.
    Type: Application
    Filed: October 28, 2010
    Publication date: January 17, 2013
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Liana Adam, Colin P. Dinney, David J. McConkey
  • LASER SCANNING CYTOMETRY MEDIATED ANALYSIS OF THERAPEUTIC EFFICACY IN TUMORS
    Publication number: 20110236909
    Abstract: This invention describes the use of a laser scanning device, for example a laser scanning CYTOMETRY (LSC), with a double-fluorescent labeling technique as a quantitative method that can be used to objectively and accurately measure endothelial cell death, endothelial tumor cell death and blood vessel density of tumor tissue. These parameters can be used as markers of efficacy in tumors treated with anti-angiogenic or traditional therapies and can distinguish patients who respond to these drugs from those who do not.
    Type: Application
    Filed: February 1, 2008
    Publication date: September 29, 2011
    Inventors: DARREN W. DAVIS, David J. McConkey