Patents by Inventor David J. Mooney

David J. Mooney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220265779
    Abstract: An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.
    Type: Application
    Filed: February 8, 2022
    Publication date: August 25, 2022
    Inventors: David J. Mooney, Cristina Borselli, Herman H. Vandenburgh, Eduardo Alexandre Barros E Silva, Lin Wang, Dimitry Shvartsman, Hannah Storrie, Jeff Lichtman
  • Publication number: 20220249741
    Abstract: The present invention provides methods and compositions for promoting dental tissue repair and/or regeneration, methods for promoting differentiation of dental pulp stem cells, methods for treating periodontal diseases, and methods for treating infection of a dental pulp in a subject in need thereof by contacting the tissue with a composition comprising a triacrylate capable of promoting dental pulp stem cells adhesion and/or proliferation.
    Type: Application
    Filed: December 8, 2021
    Publication date: August 11, 2022
    Inventors: Adam D. Celiz, Kyle Holmberg Vining, David J. Mooney
  • Publication number: 20220202727
    Abstract: The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compostions. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 30, 2022
    Inventors: Jae-Won Shin, Angelo S. Mao, Stefanie Utech, David A. Weitz, David J. Mooney, Oktay R. Uzun
  • Publication number: 20220192986
    Abstract: The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time.
    Type: Application
    Filed: November 9, 2021
    Publication date: June 23, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: Nathaniel D. Huebsch, Christopher M. Madl, Kangwon Lee, Maria M. Xu, David J. Mooney
  • Publication number: 20220107308
    Abstract: Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers.
    Type: Application
    Filed: October 14, 2021
    Publication date: April 7, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: Omar Abdel-Rahman Ali, David J. Mooney
  • Patent number: 11278604
    Abstract: A composition comprising mesoporous silica rods comprising an immune cell recruitment compound and an immune cell activation compound, and optionally comprising an antigen such as a tumor lysate. The composition is used to elicit an immune response to a vaccine antigen.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: March 22, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Jaeyun Kim, Weiwei Aileen Li, David J. Mooney
  • Publication number: 20220047778
    Abstract: The present invention provides compositions and methods that modulate the immune system in a subject.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 17, 2022
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Nisarg J. Shah, Angelo S. Mao, Matthew D. Kerr, David J. Mooney, David T. Scadden
  • Patent number: 11229607
    Abstract: The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compositions. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: January 25, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Jae-Won Shin, Angelo S. Mao, Stefanie Utech, David A. Weitz, David J. Mooney, Oktay Uzun
  • Patent number: 11224679
    Abstract: The present invention provides methods and compositions for promoting dental tissue repair and/or regeneration, methods for promoting differentiation of dental pulp stem cells, methods for treating periodontal diseases, and methods for treating infection of a dental pulp in a subject in need thereof by contacting the tissue with a composition comprising a triacrylate capable of promoting dental pulp stem cells adhesion and/or proliferation.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: January 18, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Adam D. Celiz, Kyle Holmberg Vining, David J. Mooney
  • Patent number: 11202759
    Abstract: The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: December 21, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Nathaniel D. Huebsch, Christopher M. Madl, Kangwon Lee, Maria M. Xu, David J. Mooney
  • Patent number: 11197944
    Abstract: The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: December 14, 2021
    Assignees: President and Fellows of Harvard College, CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN
    Inventors: Christine A. Cezar, Conor J. Walsh, David J. Mooney, Ellen T. Roche, Herman H. Vandenburgh, Georg N. Duda
  • Publication number: 20210353830
    Abstract: The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer.
    Type: Application
    Filed: May 14, 2021
    Publication date: November 18, 2021
    Inventors: Jeong-Yun Sun, Xuanhe Zhao, Widusha R.K. Illeperuma, Kyu Hwan Oh, Joost J. Vlassak, Zhigang Suo, Jianyu Li, David J. Mooney
  • Publication number: 20210338577
    Abstract: The present invention is directed to a biodegradable tough adhesive material comprising an interpenetrating networks (IPN) hydrogel comprising a first polymer network and a second polymer network, wherein the first polymer network comprises a first polymer covalently crosslinked with a biodegradable covalent crosslinker and the second polymer network comprises a second polymer crosslinked with ionic or physical crosslinks; a high density primary amine polymer; and a coupling agent. The present invention also provides methods preparing and using the biodegradable tough adhesive material.
    Type: Application
    Filed: October 11, 2019
    Publication date: November 4, 2021
    Inventors: Benjamin Ross Freedman, Oktay R. Uzun, David J. Mooney, Nadja M. Maldonado Luna
  • Patent number: 11150242
    Abstract: Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: October 19, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Omar Abdel-Rahman Ali, David J. Mooney
  • Publication number: 20210308322
    Abstract: Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration.
    Type: Application
    Filed: June 15, 2021
    Publication date: October 7, 2021
    Inventors: Luo Gu, Ovijit Chaudhuri, Nathaniel D. Huebsch, David J. Mooney, Max Carlton Darnell, Simon Young
  • Publication number: 20210284776
    Abstract: Disclosed herein are compositions and methods for labeling cells using click chemistry reagents. The compositions and methods disclosed herein provide a specific and efficient means of localizing desired agents to a variety of cell types in vivo and in vitro.
    Type: Application
    Filed: March 18, 2021
    Publication date: September 16, 2021
    Applicant: President and Fellows of Harvard College
    Inventors: Hua Wang, David J. Mooney
  • Patent number: 11096997
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: August 24, 2021
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
  • Patent number: 11065362
    Abstract: Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: July 20, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Luo Gu, Ovijit Chaudhuri, Nathaniel D. Huebsch, David J. Mooney, Max Carlton Darnell, Simon Young
  • Publication number: 20210205233
    Abstract: The invention provides polymer compositions for cell and drug delivery.
    Type: Application
    Filed: October 29, 2020
    Publication date: July 8, 2021
    Applicant: President and Fellows of Harvard College
    Inventors: Sidi A. Bencherif, Roger Warren Sands, Sandeep T. Koshy, David J. Mooney
  • Patent number: 11033658
    Abstract: The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: June 15, 2021
    Assignees: President and Fellows of Harvard College
    Inventors: Jeong-Yun Sun, Xuanhe Zhao, Widusha R. K. Illeperuma, Kyu H. Oh, Joost J. Vlassak, Zhigang Suo, Jianyu Li, David J. Mooney