Patents by Inventor David J. Morgan

David J. Morgan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
    Patent number: 7825120
    Abstract: Certain substituted ((piperazin-1-ylmethyl)benzyl)urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and may be useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: November 2, 2010
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley P. Morgan, Alex Muci, Erica A. Kraynack, Todd Tochimoto, Pu-Ping Lu, David J. Morgans, Jr.
  • Imidazoyl-benzamide anti-cancer agents
    Patent number: 7795448
    Abstract: Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: September 14, 2010
    Assignee: Cytokinetics, Incorporated
    Inventors: Xiangping Qian, Andrew I. McDonald, Han-Jie Zhou, Luke W. Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Chen Huang, Jianchao Wang, David J. Morgans, Jr., Bradley P. Morgan, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100210645
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 19, 2010
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, JR.
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100210634
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: May 3, 2010
    Publication date: August 19, 2010
    Inventors: Bradley P. Morgan, Erica A. Kraynack, Pu-Ping Lu, Alex Muci, David J. Morgans, JR.
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100173930
    Abstract: Provided are certain chemical entities, and methods of use to modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, neuromuscular disease, and other indications.
    Type: Application
    Filed: July 31, 2007
    Publication date: July 8, 2010
    Inventors: Alex Muci, Jeffrey T. Finer, Bradley P. Morgan, Alan James Russell, David J. Morgans, JR.
  • Certain indanyl urea modulators of the cardiac sarcomere
    Patent number: 7718657
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: May 18, 2010
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley P. Morgan, Erica A. Kraynack, Pu-Ping Lu, Alex Muci, David J. Morgans, Jr.
  • COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20100105767
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Application
    Filed: October 20, 2009
    Publication date: April 29, 2010
    Inventors: Andrew McDonald, Gustave Bergnes, Bainian Feng, David J. Morgan, JR., Steven David Knight, Kenneth A. Newlander, Dashyant Dhanak, Christopher A. Brook
  • CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
    Publication number: 20100093741
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Application
    Filed: October 5, 2009
    Publication date: April 15, 2010
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, JR.
  • Certain Chemical Entities, Compositions, and Methods
    Publication number: 20100069453
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Application
    Filed: August 13, 2009
    Publication date: March 18, 2010
    Inventors: Xiangping Qian, Luke W. Ashcraft, Jianchao Wang, Bing Yao, Hong Jiang, Gustave Bergnes, Bradley P. Morgan, David J. Morgans, JR., Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin J. Duffy, Duke Fitch, Rosanna Tedesco
  • COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20100069370
    Abstract: Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: September 3, 2009
    Publication date: March 18, 2010
    Inventors: Bradley Paul Morgan, Fady Malik, Erica Anne Kraynack, Alexander Ramon Muci, Xiangping Qian, David J. Morgans, JR.
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100029680
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: June 11, 2009
    Publication date: February 4, 2010
    Inventors: Bradley P. Morgan, David J. Morgans, JR., Alex Muci, Pu-Ping Lu, Erica A. Kraynack, Todd Tochimoto
  • Compounds, Compositions and Methods
    Publication number: 20090324511
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: May 20, 2009
    Publication date: December 31, 2009
    Inventors: Bradley P. Morgan, Alex Muci, Erica Kraynack, Pu-Ping Lu, Todd Tochimoto, David J. Morgans, JR.
  • Certain Chemical Entities, Compositions, and Methods
    Publication number: 20090312365
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Application
    Filed: January 7, 2009
    Publication date: December 17, 2009
    Inventors: Xiangping Qian, Andrew I. McDonald, Han-Jie Zhou, Luke W. Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Huang, Jianchao Wang, David J. Morgans, JR., Bradley P. Morgan, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20090306127
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Application
    Filed: January 7, 2009
    Publication date: December 10, 2009
    Inventors: Xiangping Qian, Andrew I. McDonald, Han-Jie Zhou, Luke W. Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Chen Huang, Jianchao Wang, David J. Morgans, JR., Bradley P. Morgan, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Compounds, compositions and methods
    Patent number: 7629477
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: December 8, 2009
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Andrew McDonald, Gustave Bergnes, Bainian Feng, David J. Morgans, Jr., Steven David Knight, Kenneth A. Newlander, Dashyant Dhanak, Christopher A. Brook
  • CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
    Publication number: 20090286841
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Application
    Filed: March 2, 2009
    Publication date: November 19, 2009
    Inventors: Xiangping QIAN, Andrew I. McDonald, Han-Jle Zhou, Luke W. Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Chen Huang, Jlanchao Wang, David J. Morgans, JR., Bradley P. Morgan, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Imidazopyridinyl-benzamide anti-cancer agents
    Patent number: 7618981
    Abstract: Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: November 17, 2009
    Assignees: Cytokinetics, Inc., SmithKline Beecham Corporation
    Inventors: Xiangping Qian, Andrew I. McDonald, Han-Jie Zhou, Luke W. Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Chen Huang, Jianchao Wang, David J. Morgans, Jr., Bradley P. Morgan, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Certain chemical entities, compositions, and methods
    Publication number: 20090275537
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Application
    Filed: August 11, 2008
    Publication date: November 5, 2009
    Inventors: Xiangping Qian, Chihyuan (Grace) Chuang, Pu-Ping Lu, Bing Yao, Qing (Kevin) Lu, Hong Jiang, Wenyue Wang, Bradley P. Morgan, David J. Morgans, JR.
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20090264466
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Application
    Filed: January 23, 2009
    Publication date: October 22, 2009
    Inventors: Xiangping Qian, Hong Jiang, Bradley P. Morgan, David J. Morgans, JR.
  • Compositions and methods for treating heart failure
    Patent number: 7605164
    Abstract: Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: October 20, 2009
    Assignee: Cytokinetics, Inc.
    Inventors: Fady Malik, Adam Lewis Tomasi, Bainian Feng, Erica Anne Kraynack, Kathleen A. Elias, Pu-Ping Lu, Whitney Walter Smith, Xiangping Qian, David J. Morgans, Jr.