Abstract: A system and associated methods are disclosed for managing clinical notification delivery and related compliance monitoring. In certain embodiments, the clinical notifications are automatically driven by healthcare information associated with a specific patient, and are delivered to an electronic device of the patient at a remote location. Thereafter, compliance monitoring may be initiated to log the patient's intent to act in accordance with the notification. For instance, in certain embodiments, the notification relates to a reminder regarding scheduled medication administration for the particular patient, where a reply to the notification indicates whether the patient is following the scheduled medication administration.