Patents by Inventor David J. Perry
David J. Perry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10023619Abstract: Methods for the production of synthetic spider silk-like proteins in corn endosperm, plant leaf or plant shoot tissue are provided. The present invention provides further methods for the identification of synthetic spider silk-like proteins in corn endosperm, plant leaf or plant shoot tissue.Type: GrantFiled: March 27, 2015Date of Patent: July 17, 2018Assignee: University of WyomingInventors: Randolph V. Lewis, David J. Perry
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Patent number: 8991661Abstract: A material handling apparatus for conveying an article having a ferromagnetic component includes a hopper, a discharge, and a magnet. The hopper has an inlet and outlet and defines a hopper volume for receiving a plurality of the articles to be conveyed. The discharge is spaced from and downstream of the hopper. The magnet is movable between an attracting position proximate the hopper and a discharge position proximate the discharge.Type: GrantFiled: April 11, 2011Date of Patent: March 31, 2015Assignee: Multisorb Technologies, Inc.Inventors: Anthony J. Arnone, Michael J. Helm, Jason L. Kerkeslager, David S. Payne, David J. Perry, Thomas H. Powers
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Patent number: 8660332Abstract: Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.Type: GrantFiled: March 13, 2013Date of Patent: February 25, 2014Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip J. Morrissey, Thaddeus C. George, Brian E. Hall, Cathleen A. Zimmerman, David J. Perry
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Patent number: 8379136Abstract: A system and method for high numeric aperture imaging systems includes a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the transmitted portion and reflected portion are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved.Type: GrantFiled: February 14, 2011Date of Patent: February 19, 2013Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, David J. Perry
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Publication number: 20120257951Abstract: A material handling apparatus for conveying an article having a ferromagnetic component includes a hopper, a discharge, and a magnet. The hopper has an inlet and outlet and defines a hopper volume for receiving a plurality of the articles to be conveyed. The discharge is spaced from and downstream of the hopper. The magnet is movable between an attracting position proximate the hopper and a discharge position proximate the discharge.Type: ApplicationFiled: April 11, 2011Publication date: October 11, 2012Applicant: MULTISORB TECHNOLOGIES, INC.Inventors: Anthony J. Arnone, Michael J. Helm, Jason L. Kerkeslager, David S. Payne, David J. Perry, Thomas H. Powers
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Publication number: 20120013785Abstract: A system and method for high numeric aperture imaging systems includes a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the transmitted portion and reflected portion are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved.Type: ApplicationFiled: February 14, 2011Publication date: January 19, 2012Applicant: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, David J. Perry
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Publication number: 20110203943Abstract: The invention generally relates to an absorbent article comprising an absorbent having printed indicia thereon wherein the printing comprises colorant and resin, and a protective coating over the printing.Type: ApplicationFiled: February 24, 2010Publication date: August 25, 2011Inventors: David J. Perry, John M. Sherry
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Patent number: 7889263Abstract: A system and method for high numeric aperture imaging systems includes a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the transmitted portion and reflected portion are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved.Type: GrantFiled: April 5, 2010Date of Patent: February 15, 2011Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, David J. Perry
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Publication number: 20100188559Abstract: A system and method for high numeric aperture imaging systems includes a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the transmitted portion and reflected portion are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved.Type: ApplicationFiled: April 5, 2010Publication date: July 29, 2010Applicant: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, David J. Perry
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Patent number: 7719598Abstract: A system and method for high numeric aperture imaging systems includes a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the transmitted portion and reflected portion are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved.Type: GrantFiled: January 24, 2006Date of Patent: May 18, 2010Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, David J. Perry
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Patent number: 7567695Abstract: Combinatorially-synthesized deoxyribonucleic acid (DNA) oligonucleotides attached to encoded beads that are hybridized to amplified and labeled genomic DNA or ribonucleic acid (RNA) are analyzed using a flow imaging system. Oligonucleotides and corresponding reporters are bound to the surfaces of a plurality of small beads such that different beads bear different oligo sequences. Each bead bears a unique optical signature comprising a predefined number of unique reporters, where each reporter comprises a predefined combination of different fluorochromes. The composite spectral signature in turn identifies the unique nucleotide sequence of its attached oligo chains. This optical signature is rapidly decoded using an imaging system to discriminate the different reporters attached to each bead in a flow in regard to color and spatial position on the bead.Type: GrantFiled: March 11, 2005Date of Patent: July 28, 2009Assignee: Amnis CorporationInventors: Keith L. Frost, David A. Basiji, Richard A. Bauer, Rosalynde J. Finch, William E. Ortyn, David J. Perry
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Patent number: 7087877Abstract: A pair of optical gratings are used to modulate light from an object, and the modulated light from either grating is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.Type: GrantFiled: January 28, 2005Date of Patent: August 8, 2006Assignee: Amnis CorporationInventors: William E. Ortyn, Michael J. Seo, David A. Basiji, Keith L. Frost, David J. Perry
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Patent number: 7009651Abstract: A system and method for high numeric aperture imaging systems includes a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the transmitted portion and reflected portion are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved.Type: GrantFiled: October 12, 2001Date of Patent: March 7, 2006Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, David J. Perry
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Patent number: 6934408Abstract: Combinatorially-synthesized deoxyribonucleic acid (DNA) oligonucleotides attached to encoded beads that are hybridized to amplified and labeled genomic DNA or ribonucleic acid (RNA) are analyzed using a flow imaging system. Oligonucleotides and corresponding reporters are bound to the surfaces of a plurality of small beads such that different beads bear different oligo sequences. Each bead bears a unique optical signature comprising a predefined number of unique reporters, where each reporter comprises a predefined combination of different fluorochromes. The composite spectral signature in turn identifies the unique nucleotide sequence of its attached oligo chains. This optical signature is rapidly decoded using an imaging system to discriminate the different reporters attached to each bead in a flow in regard to color and spatial position on the bead.Type: GrantFiled: October 12, 2001Date of Patent: August 23, 2005Assignee: Amnis CorporationInventors: Keith L. Frost, David A. Basiji, Richard A. Bauer, Rosalynde J. Finch, William E. Ortyn, David J. Perry
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Patent number: 6875973Abstract: A pair of optical gratings are used to modulate light from an object, and the modulated light from either optical is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.Type: GrantFiled: April 9, 2004Date of Patent: April 5, 2005Assignee: Amnis CorporationInventors: William E. Ortyn, Michael J. Seo, David A. Basiji, Keith L. Frost, David J. Perry
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Publication number: 20040217256Abstract: A pair of optical gratings are used to modulate light from an object, and the modulated light from either optical is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.Type: ApplicationFiled: April 9, 2004Publication date: November 4, 2004Applicant: Amnis CorporationInventors: William E. Ortyn, Michael J. Seo, David A. Basiji, Keith L. Frost, David J. Perry
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Patent number: 6532061Abstract: Frequency domain velocity measurements and time domain velocity measurements are made using light from cells or other objects. An optical grating is used to modulate the light from an object so that it has a frequency proportional to the velocity of the object. Depending upon the embodiment, the pitch of the optical grating is uniform or varying. The modulated light is detected and various signal processing techniques, such as a Fast Fourier Transform function, are used to indicate the velocity of the object. Preferably, the velocity measured is applied in determining a timing signal employed for synchronization of an image of the object and an detector signal in an optical analysis system that uses a time delay integration detector to determine characteristics of the object in response to light from the object.Type: GrantFiled: August 24, 2001Date of Patent: March 11, 2003Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Richard A. Bauer, Keith L. Frost, David J. Perry, James K. Riley
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Patent number: 6507391Abstract: Frequency domain velocity measurements and time domain velocity measurements are made using light from cells or other objects. An optical grating is used to modulate the light from an object so that it has a frequency proportional to the velocity of the object. Depending upon the embodiment, the pitch of the optical grating is uniform or varying. The modulated light is detected, producing an analog signal that is then digitally sampled. Time domain signal processing techniques are used to determine the velocity of the object from the digital samples. Preferably, the velocity measured is applied in determining a timing signal employed for synchronization of an image of the object and an detector signal in an optical analysis system that uses a time delay integration (TDI) detector to determine characteristics of the object in response to light from the object.Type: GrantFiled: August 24, 2001Date of Patent: January 14, 2003Assignee: Amnis CorporationInventors: James K. Riley, David A. Basiji, Richard A. Bauer, Keith L. Frost, William E. Ortyn, David J. Perry
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Patent number: 6453060Abstract: A system for collecting images at multiple wavelengths for image analysis of biological specimens. The process separates contrasts for images of a biological specimen prepared with a chromogen. Light wavelengths matched with each chromogen optimize separation for each image. Computing attenuation coefficients and extinction coefficients for each chromogen provides for determination of the concentration of each chromogen. A chromogen separator allows for subtracting predetermined chromogens to generate new images and aid in identification of cell morphology. The system can perform the image analysis of the new images using image processing techniques such as segmentation, feature calculation and object classification. At each stage of image processing, data from each of the new images may influence the processing of the other images.Type: GrantFiled: June 29, 1999Date of Patent: September 17, 2002Assignee: Tri Path Imaging, Inc.Inventors: James K. Riley, Michael G. Meyer, David J. Perry, Andrew D. Silber
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Publication number: 20020122167Abstract: Frequency domain velocity measurements and time domain velocity measurements are made using light from cells or other objects. An optical grating is used to modulate the light from an object so that it has a frequency proportional to the velocity of the object. Depending upon the embodiment, the pitch of the optical grating is uniform or varying. The modulated light is detected, producing an analog signal that is then digitally sampled. Time domain signal processing techniques are used to determine the velocity of the object from the digital samples. Preferably, the velocity measured is applied in determining a timing signal employed for synchronization of an image of the object and an detector signal in an optical analysis system that uses a time delay integration (TDI) detector to determine characteristics of the object in response to light from the object.Type: ApplicationFiled: August 24, 2001Publication date: September 5, 2002Inventors: James K. Riley, David A. Basiji, Richard A. Bauer, Keith L. Frost, William E. Ortyn, David J. Perry