Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments. The present disclosure provides compounds of Formula (I).

Abstract: The present invention relates to compositions and methods for cancer treatment comprising compounds of Formulae I, II, and III. In some aspects, the invention relates to the treatment of B-cell Lymphoma or other hematopoietic cancers. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as, for example, B-cell lymphoma, using a combination of one or more compounds of Formulae I, II, and III. Combination therapy with, for example, 26S proteasome inhibitors, such as, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formulae I, II, and III. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.

Abstract: The present invention relates to compositions and methods for cancer treatment comprising compounds of Formulae I, II, and III. In some aspects, the invention relates to the treatment of B-cell Lymphoma or other hematopoietic cancers. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as, for example, B-cell lymphoma, using a combination of one or more compounds of Formulae I, II, and III. Combination therapy with, for example, 26S proteasome inhibitors, such as, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formulae I, II, and III. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.

Abstract: A poker card game and apparatus and software for its play are disclosed, particularly adapted for casino play, in which each player in a given game, using only a single dealt hand, plays simultaneously separately against the dealer (the house) and against the other players. Betting for the two lines of play may be separate or linked, and a player can elect to play only against the dealer or to play both games together. The game is played as a form of five-card stud with betting before each deal. At the end of each game a player's status as to whether he/she beat the dealer, beat the other players or both is determined and displayed, and winners are paid accordingly. Conventional dealing may be used, but it is preferred that a biased deal, which enhances the opportunities for players to be dealt reasonably good poker hands, be used.

Abstract: A poker card game and apparatus and software for its play are disclosed, particularly adapted for casino play, in which each player in a given game, using only a single dealt hand, plays simultaneously separately against the dealer (the house) and against the other players. Betting for the two lines of play may be separate or linked, and a player can elect to play only against the dealer or to play both games together. The game is played as a form of five-card stud with betting before each deal. At the end of each game a player's status as to whether he/she beat the dealer, beat the other players or both is determined and displayed, and winners are paid accordingly. Conventional dealing may be used, but it is preferred that a biased deal, which enhances the opportunities for players to be dealt reasonably good poker hands, be used.

Abstract: A card game begins with designating at least one playing card to be a substitute card and defining a substitution pattern for the substitute cards. The first player is dealt a first player hand of cards and at least one additional player hand of cards. The player plays the first player hand to completion. For each additional hand, the substitute cards are copied into other player hands to replace a card in that hand, according to the substitution pattern, only if the substitution results in a higher poker ranking for the hand. Players are rewarded based on the final poker ranking of each player hand after substitution, if any.

Abstract: A card game begins with designating at least one playing card to be a substitute card and defining a substitution pattern for the substitute cards: The first player is dealt a first player hand of cards. The player plays the first player hand to completion and receives at least one additional player hand of cards. For each additional hand, the substitute cards are copied into other player hands to replace a card in that hand, according to the substitution pattern, only if the substitution results in a higher poker ranking for the hand. Players are rewarded based on the final poker ranking of each player hand after substitution, if any.

Abstract: A ladder pad device is used to add comfort in carrying a ladder. The ladder pad device has a plurality of side faces, a top face connected to the plurality of side faces, a bottom face connected to a plurality of side faces and attachment means covering a majority of one of the side faces to attach the ladder pad device to the ladder.

Abstract: A gas flow unit such as a vaporizer mountable on a gas administration apparatus such as an anaesthesia machine in plug-in fashion includes an interlock system which prevents a valve for controlling the admission to the unit of gas from a supply provided by the apparatus from being operated before a locking mechanism has locked the unit to the anaesthesia machine.The interlock system also includes actuating means which when the unit is mounted on the anaesthesia machine, opens respective valve members in ports located on the anaestheia machine only when the control valve is moved to its operating position.In the case when two similar units are mounted side-by-side on the anaesthesia machine and intended for use as alternatives, the interlock system includes pins which when the control valve on one unit is moved to its operating position, extend outwardly from the unit to prevent the control valve on the other unit from being operated.

Abstract: An elongated sheet of stainless steel material includes alternately spaced apart laterally extending slots and ridges formed by removing a length of material and then applying downward pressure within the slots to form downwardly extending rounded slot edges. Upward pressure is applied along a line between the slots to form rounded ridges having oppositely extending downwardly sloping surfaces which merge into flat surfaces extending to the adjacent slot edges. The opposite sides of the floor members include downwardly extending side walls which slope inwardly towards each other such that side walls of adjacent floor members form elongated openings which increase in width downwardly. An A-shaped strengthening member may be provided under the floor member along its center line and supported by vertically disposed end channels the upper legs of which have downwardly extending return bend portions providing rounded edges therealong.

Abstract: An elongated sheet of stainless steel material includes alternately spaced apart laterally extending slots and ridges formed by removing a length of material and then applying downward pressure within the slots to form downwardly extending rounded slot edges. Upward pressure is applied along a line between the slots to form rounded ridges having oppositely extending downwardly sloping surfaces which merge into flat surfaces extending to the adjacent slot edges. The opposite sides of the floor members include downwardly extending side walls which slope inwardly towards each other such that side walls of adjacent floor members form elongated openings which increase in width downwardly. An A-shaped strengthening member may be provided under the floor member along its center line and supported by vertically disposed end channels the upper legs of which have downwardly extending return bend portions providing rounded edges therealong.