Abstract: A method for treating pulmonary hypertension and other diseases involving a defect in collagen metabolism, by administration of an effective amount of a liposome encapsulated copolymer conjugate antifibrotic composition, is disclosed. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). Consistent, high loadings (>98%) of the antifibrotic agent are achieved by first forming a dipeptide with L-lysine, after which the dipeptide is copolymerized with the polymer component to form the copolymer conjugate. The polymer is preferably poly(ethylene glycol) having a weight average molecular weight of from about 500 to about 15,000. There is thus provided the efficient delivery and rateable release of the antifibrotic agent to inhibit collagen accumulation and thereby treat the diseases involved.

Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collagen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.

Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.

Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.

Abstract: A welding electrode arrangement comprising an inner electrode and a plurality of electrically interconnected outer electrodes defining a closed figure about the inner electrode, the outer electrodes being resilient in a direction substantially parallel to the axis of the closed figure, the outer electrodes further being in the form of a plurality of inwardly directed fingers extending from and integral with an outer connecting rim.

Abstract: A cathode structure for a sodium sulphur cell is formed by putting a fibre matrix into a mould which is closed to shape the matrix to the required form with compression of the fibrous material, the mould being kept at a temperature below 12.degree. C. and preferably between 8.degree. and 10.degree. C. while liquid sulphur is injected into the compressed fibre material.

Abstract: For filling sodium into the sodium reservoir of a sodium-sulphur cell, the reservoir is closed except for an open-ended metal filling tube. In a filling machine, the cell is heated to a temperature such that the sodium will remain liquid, the tube is temporarily sealed around a sodium outlet of the filling machine by an inflatable seal, the reservoir is evacuated of air, flushed with an inert gas and then evacuated for vacuum filling with a metered quantity of sodium through a sodium feed tube within said outlet and extending downwardly into the filling tube. The sodium is pressurized using an inert gas to force the sodium into the cell, the gas is evacuated and the filling tube on the cell sealed by pinching and welding.