Abstract: Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.

Abstract: A method for characterizing exposure levels in a platesetter comprises exposing regions of a plate at different exposure levels by modulating the power of an exposure beam and then analyzing the plate after development to determine a desired exposure level for plates on the platesetter by reference to the regions receiving the different exposure levels. The plates are preferably exposed in an area outside of a printing area. In this way, the exposure test can be performed as part of the normal plate printing process. The plate is not consumed. Moreover, the plate exposure setting can be constantly monitored throughout production in one implementation.

Abstract: A visual sensor has a first portion and a second portion. The sensor is able to detect the state of one or more imaging parameters such as exposure setting, pulse width modulation, focus, balance, spot ellipticity, sidelobe size, shape, and intensity, media gamma, edge sharpness, dot gain, uniformity, ink receptivity, physical changes in the media, pattern dependent effects such as dot gain or tone resolution compared to the type of halftone used, and sensitivity to calibrated position or exposure errors. The first image portion has a first imaging characteristic, and the second image portion has a second imaging characteristic. Imaging characteristics are characteristics of an image, including, but not limited to apparent density level, tint, color, reflectivity, absorption, granularity or microstructure, size, shape, distribution, degree of randomness, structure, edge sharpness, and depth or dimension.

Abstract: An article of manufacture includes a medium having a plurality of checkerboard patches recorded thereon. Each of the patches is of equal nominal tint and formed of dots. The dots of each of the patches are of equal nominal size with the size being different from that of the dots forming all other patches. One of the patches is arranged adjacent to all other patches.

Abstract: A fluorescence dot area meter for accurately measuring halftone dot area on a printing plate having an emulsion containing one or more fluorescent compounds. The fluorescent dot area meter generally includes an illumination source for providing light having a first range of wavelengths, a system for exposing the printing plate to this light to cause the printing plate to emit light (fluoresce) within a second, higher range of wavelengths, and a system for determining halftone dot area based on a measurement of the light emitted by the printing plate.

Abstract: A fluorescence dot area meter for accurately measuring halftone dot area on a printing plate having an emulsion containing one or more fluorescent compounds. The fluorescent dot area meter generally includes an illumination source for providing light having a first range of wavelengths, a system for exposing the printing plate to this light to cause the printing plate to emit light (fluoresce) within a second, higher range of wavelengths, and a system for determining halftone dot area based on a measurement of the light emitted by the printing plate.