Patents by Inventor David J. Roush

David J. Roush has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS COMPRISING AN ANTI-CTLA4 MONOCLONAL ANTIBODY WITH REDUCED HOST CELL PROTEINS AND INCREASED POLYSORBATE-80 STABILITY
    Publication number: 20240115701
    Abstract: Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from the production protein using chromatographic processes. Also provided herein are compositions comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4). In another aspect, such compositions further comprise a reduced level of host cell proteins and/or increased level of polysorbate-80 (PS-80) stability.
    Type: Application
    Filed: September 18, 2020
    Publication date: April 11, 2024
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Rebecca A. Chmielowski, Francis K. Insaidoo, Justin B. Miller, David J. Roush, Darshini Shah, John P. Welsh
  • NOVEL PROCESSES FOR PREPARING CONJUGATES OF THE IL-2 PROTEIN
    Publication number: 20230272001
    Abstract: Disclosed herein are novel processes for preparing IL-2 conjugates with one or more water-soluble polymers. In one embodiment, the IL-2 conjugate comprises five poly(ethylene glycol) polymers each of which is covalently attached to the IL-2 moiety via a releasable linkage to an amino group of the IL-2 moiety.
    Type: Application
    Filed: May 17, 2021
    Publication date: August 31, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Joshua Lee, Gregory F. Pirrone, Michael J. Iammarino, David J. Roush
  • METHODS OF SEPARATING HOST CELL LIPASES FROM A PRODUCTION PROTEIN IN CHROMATOGRAPHIC PROCESSES
    Publication number: 20220267369
    Abstract: Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from the production protein using chromatographic processes. Also provided are pharmaceutical compositions comprising less than 1 ppm of a host cell lipase.
    Type: Application
    Filed: July 24, 2019
    Publication date: August 25, 2022
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Rebecca A. Chmielowski, Francis K. Insaidoo, Justin B. Miller, David J. Roush, Darshini Shah, John P. Welsh
  • Process for preparing recombinant insulin using microfiltration
    Patent number: 10562951
    Abstract: The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification unit operation reduce both soluble and insoluble impurities and exchange the insulin product into a suitable buffer for downstream purification.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: February 18, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Sean S. Gant, Michael J. Iammarino, Kristi Kerchner, Michael A. Rauscher, David J. Roush, Christopher H. Smith, Martin Chandler, Matthew Petroff
  • PROCESS FOR PREPARING RECOMBINANT INSULIN USING MICROFILTRATION
    Publication number: 20180044395
    Abstract: The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification unit operation reduce both soluble and insoluble impurities and exchange the insulin product into a suitable buffer for downstream purification.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Sean S. Gant, Michael J. Iammarino, Kristi Kerchner, Michael A. Rauscher, David J. Roush, Christopher H. Smith, Martin Chandler, Matthew Petroff
  • Purification process
    Patent number: 6610822
    Abstract: There is disclosed a process for purifying a natural product using a two-phase, multi-solvent system followed by vacuum concentration and back extraction. The method allows for the removal of impurities by controlling the polarity balance of a two-phase system by manipulating the proportions of the four solvents and subsequently the relative distribution of the product versus the impurities.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: August 26, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Martin A. Chandler, Kent E. Goklen, Steven S. Lee, David J. Roush
  • Purification process
    Publication number: 20020028916
    Abstract: There is disclosed a process for purifying a natural product using a two-phase, multi-solvent system followed by vacuum concentration and back extraction. The method allows for the removal of impurities by controlling the polarity balance of a two-phase system by manipulating the proportions of the four solvents and subsequently the relative distribution of the product versus the impurities.
    Type: Application
    Filed: August 1, 2001
    Publication date: March 7, 2002
    Inventors: Martin A. Chandler, Kent E. Goklen, Steven S. Lee, David J. Roush