Patents by Inventor David J. SALANT

David J. SALANT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant ROBO2 proteins, compositions, methods and uses thereof
    Patent number: 11970524
    Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: April 30, 2024
    Assignees: PFIZER INC., BOSTON MEDICAL CENTER CORPORATION
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Nathan Higginson-Scott, Michael Shamashkin, Matthew Russo, Stefano V. Gulla, Zong Sean Juo, Sreekumar R. Kodangattil, Weining Lu, Xueping Fan, David J. Salant
  • Anti-ROBO2 antibodies, compositions, methods and uses thereof
    Patent number: 11365253
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: June 21, 2022
    Assignees: Pfizer Inc., Boston Medical Center Corporation
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Eric M. Bennett, Nathan Higginson-Scott, Huilan Gao, Zong Sean Juo, Stefano V. Gulla, Christine Huard, Sreekumar R. Kodangattil, Jian Li, Weining Lu, Xueping Fan, David J. Salant
  • RECOMBINANT ROBO2 PROTEINS, COMPOSITIONS, METHODS AND USES THEREOF
    Publication number: 20210214414
    Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 15, 2021
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Nathan Higginson-Scott, Michael Shamashkin, Matthew Russo, Stefano V. Gulla, Zong Sean Juo, Sreekumar R. Kodangattil, Weining Lu, Xueping Fan, David J. Salant
  • Recombinant ROBO2 proteins, compositions, methods and uses thereof
    Patent number: 10906955
    Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: February 2, 2021
    Assignees: Pfizer Inc., Boston Medical Center Corporation
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Nathan Higginson-Scott, Michael Shamashkin, Matthew Russo, Stefano V. Gulla, Zong Sean Juo, Sreekumar R. Kodangattil, Weining Lu, Xueping Fan, David J. Salant
  • ANTI-ROBO2 ANTIBODIES, COMPOSITIONS, METHODS AND USES THEREOF
    Publication number: 20200157212
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
    Type: Application
    Filed: June 8, 2018
    Publication date: May 21, 2020
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Eric M. Bennett, Nathan Higginson-Scott, Huilan Gao, Zong Sean Juo, Stefano V. Gulla, Christine Huard, Sreekumar R. Kodangattil, Jian Li, Weining Lu, Xueping Fan, David J. Salant
  • Method for treating kidney disease with a SLIT2-binding extracellular domain of ROBO2
    Patent number: 10358677
    Abstract: Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: July 23, 2019
    Assignee: BOSTON MEDICAL CENTER CORPORATION
    Inventors: Weining Lu, Xueping Fan, David J. Salant
  • RECOMBINANT ROBO2 PROTEINS, COMPOSITIONS, METHODS AND USES THEREOF
    Publication number: 20180346542
    Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
    Type: Application
    Filed: June 1, 2018
    Publication date: December 6, 2018
    Inventors: Stephen Berasi, Janet Elizabeth Buhlmann, Nathan Higginson-Scott, Michael Shamashkin, Matthew Russo, Stefano V. Gulla, Zong Sean Juo, Sreekumar R. Kodangattil, Weining Lu, Xueping Fan, David J. Salant
  • ROBO2 INHIBITORY COMPOSITIONS COMPRISING SLIT2-BINDING EXTRACELLULAR DOMAIN OF ROBO2
    Publication number: 20170114412
    Abstract: Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.
    Type: Application
    Filed: January 6, 2017
    Publication date: April 27, 2017
    Applicant: BOSTON MEDICAL CENTER CORPORATION
    Inventors: Weining LU, Xueping FAN, David J. SALANT
  • ROBO2 inhibitory compositions comprising SLIT2-binding extracellular domain of ROBO2
    Patent number: 9572879
    Abstract: Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: February 21, 2017
    Assignee: Boston Medical Center Corporation
    Inventors: Weining Lu, Xueping Fan, David J. Salant
  • SLIT-ROBO SIGNALING FOR DIAGNOSIS AND TREATMENT OF KIDNEY DISEASE
    Publication number: 20150037325
    Abstract: Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte F-actin cytoskeleton and foot process structure in the kidney.
    Type: Application
    Filed: January 4, 2013
    Publication date: February 5, 2015
    Inventors: Weining Lu, Xueping Fan, David J. Salant
  • System and method for multi-product clock auctions
    Patent number: 8577746
    Abstract: A system and method for adjusting prices and/or quantities of products in a multi-product clock auction are disclosed. An auction manager module determines first prices for the products and subsequently receives first bids from one or more bidding devices based on the first prices. After receiving first bids using the first prices, the auction manager module modifies the first prices to generate adjusted prices if the first bids indicate a product is oversubscribed. After receiving second bids using the adjusted prices, if a product is undersubscribed, the auction manager module rolls back the adjusted price of the undersubscribed product to the first price. In one embodiment, the auction manager module also rolls back product quantities from the second bids to quantities from the first bids if such a modification alleviates product undersubscription.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: November 5, 2013
    Assignee: Auction Technologies, LLC
    Inventors: Paul R. Milgrom, David J. Salant
  • DIAGNOSTICS FOR MEMBRANOUS NEPHROPATHY
    Publication number: 20130280738
    Abstract: The invention provides immunoassays for detecting serum auto-antibodies reactive against a phospholipase A2 receptor (PLA2R) and uses thereof for diagnosis and prognosis evaluation of idiopathic membranous nephropathy (MN).
    Type: Application
    Filed: July 3, 2013
    Publication date: October 24, 2013
    Inventors: David J. Salant, Laurence H. Beck, Gerard Lambeau
  • Diagnostics for membranous nephropathy
    Patent number: 8507215
    Abstract: The invention provides immunoassays for detecting serum auto-antibodies reactive against a phospholipase A2 receptor (PLA2R) and uses thereof for diagnosis and prognosis evaluation of idiopathic membranous nephropathy (MN).
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: August 13, 2013
    Assignees: Boston Medical Center Corporation, Le Centre National de la Recherche Scientifique
    Inventors: David J Salant, Laurence H. Beck, Gerard Lambeau
  • DIAGNOSTICS FOR MEMBRANOUS NEPHROPATHY
    Publication number: 20110177534
    Abstract: The invention relates to immunoassays, reagents, therapeutics and methods of diagnosing and prognosis evaluation of idiopathic membranous nephropathy (MN). Immunoassays comprise enzyme-linked immunoabsorbent assays and nephelometric immunoassays for serum auto-antibodies reactive against a phospholipase A2 receptor (PLA2R). Therapeutic methods include removal of the auto-antibodies by absorbance or administration of soluble PLA2R or fragments to sequester the auto-antibodies.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 21, 2011
    Applicants: BOSTON MEDICAL CENTER CORPORATION, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: David J. SALANT, Laurence H. BECK, Gerard LAMBEAU