Patents by Inventor David J. Sherratt

David J. Sherratt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6743780
    Abstract: A system is described which utilizes a novel system of repressor titration for maintenance of a plasmid useful in gene therapy and production of a recombinant protein. The system utilizes a transformed host cell containing a plasmid including an operator susceptible to binding by a repressor expressed in trans, a first chromosomal gene encoding the repressor, and a second chromosomal gene that is functionally associated with an operator and essential for cell growth, wherein the plasmid is present in the cell in sufficient numbers to titrate the repressor such that the essential gene is expressed, thereby permitting cell growth.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: June 1, 2004
    Assignee: Cobra Biologics Limited
    Inventors: Julian A. J. Hanak, Steven G. Williams, Scott D. Gorman, David J. Sherratt
  • Patent number: 5972708
    Abstract: A system is described which utilizes a novel system of repressor titration for maintenance of a plasmid useful in gene therapy and production of a recombinant protein. The system utilizes a transformed host cell containing a plasmid including an operator susceptible to binding by a repressor expressed in trans, a first chromosomal gene encoding the repressor, and a second chromosomal gene that is functionally associated with an operator and essential for cell growth, wherein the plasmid is present in the cell in sufficient numbers to titrate the repressor such that the essential gene is expressed, thereby permitting cell growth.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: October 26, 1999
    Assignee: Cobra Therapeutics Limited
    Inventors: David J. Sherratt, Steven G. Williams, Julian A.J. Hanak