Patents by Inventor David J. Stanton

David J. Stanton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10532068
    Abstract: Disclosed herein is a method for inhibiting expression of a gene of a subject comprising administering (1) a composition comprising R-(L)a-(G)b; wherein R is an oligonucleotide selected from the group consisting of DNA, RNA, siRNA, and microRNA; L is a linker and each occurrence of L is independently selected from Table 3; G is a targeting ligand and each occurrence of G is independently selected from Table 4; each of a and b is independently 0, 1, 2, 3 or 4; and (2) a composition comprising (P)c-(L)d-(G)e; wherein P is a peptide and each occurrence of P is independently selected from Table 2; L is a linker and each occurrence of L is independently selected from Table 3; G is a targeting ligand and each occurrence of G is independently selected from Table 4; d is 0, 1, 2, 3, 4, 5 or 6; and each of c and e is independently 1, 2, 3, 4, 5 or 6. Compositions in (1) and (2) can be co-administered or sequentially administered.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: January 14, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Steven L. Colletti, Thomas J. Tucker, David M. Tellers, Boyoung Kim, Rob Burke, Kathleen B. Calati, Matthew G. Stanton, Rubina G. Parmar, Jeffrey G. Aaronson, Weimin Wang
  • Patent number: 6249703
    Abstract: A patient programmer for facilitating patient control over an implanted medical device, such as an implanted spinal cord stimulator or the like, is disclosed. A programmer in accordance with the present invention is a portable, light-weight, easy to use patient programmer. The programmer enables a patient to control the operation of his or her implanted device outside of a clinical setting. The programmer incorporates features which ensure that users of varying ages, education levels, dexterity levels, physical and mental health will be able to safely control the operation of their implanted devices, within predefined limits established by a physician or clinician. Circuitry is provided for avoiding battery depletion and/or undesired programmer/implanted device communication in the event that the programmer's key is accidentally depressed (for example, due to being jammed into a purse or pocket) or is depressed repeatedly or continuously over an extended period of time.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: June 19, 2001
    Assignee: Medtronic, Inc.
    Inventors: David J. Stanton, Gregory A. Hrdlicka, Charles M. Meyerson, Todd A. Kallmyer
  • Patent number: 5354326
    Abstract: A connector for establishing an external connection with multiple-conductor implantable leads. The connector body is generally cylindrical in shape and includes a unique twist lock design. The cylindrical connector body has two sections which rotate axially with respect to one another, from an `open` position to a `closed` position. Each of the sections has a longitudinal slot therein extending along its surface parallel to the cylindrical axis of the connector. In the `open` position, the slots in the respective sections are in alignment, forming a single longitudinal opening. The opening is keyed to accept an elongated end piece from a lead stylet, the end piece being attached to the end of the implantable electrode. The end piece supports the end of the lead such that the multiple, spaced apart electrical contacts disposed on the lead are exposed on at least one side.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: October 11, 1994
    Assignee: Medtronic, Inc.
    Inventors: Richard H. Comben, Barry J. Grant, Michael D. Serfling, Thomas E. Cross, Jr., David J. Stanton
  • Patent number: 4690144
    Abstract: A transcutaneous electrical tissue stimulator comprises an electrical tissue stimulation generator (10, 41) attachable to the human body and a remote controller (37, 40) therefor. Generator (10) includes a plurality of rigid printed circuit boards (73-75) having components (91, 92) mounted thereon, each circuit board (73-75) interconnected with flexible printed circuit board (76, 77) and terminal means (51-54) for delivery of electrical tissue stimulation to electrodes (12-15). Remote programmer (37, 40) comprises user controls (39) for control of generator (10, 41) stimulation mode or parameters via telemetric link (42d, 42a).
    Type: Grant
    Filed: April 2, 1982
    Date of Patent: September 1, 1987
    Assignee: Medtronic, Inc.
    Inventors: Mark T. Rise, David J. Stanton
  • Patent number: 4539993
    Abstract: A tissue stimulator of the type which provides short intervals of stimulation followed by longer intervals of rest is provided with a fail-safe system for turning off the stimulator if the stimulation interval exceeds a predetermined maximum interval. A timer times each "on" interval. If the "on" interval exceeds the predetermined maximum, the timer times out and shuts off stimulation.
    Type: Grant
    Filed: November 18, 1982
    Date of Patent: September 10, 1985
    Assignee: Medtronic, Inc.
    Inventor: David J. Stanton
  • Patent number: 4392496
    Abstract: A dual channel neuromuscular stimulator. Pulses developed by a pulse generator are transmitted alternately on both channels to involuntarily contract muscles. The stimulator has variable on/off cycling capability to provide flexibility in meeting the stimulation needs of patients and has output current adjustments and other variable parameter settings to achieve optimum neuromuscular stimulation. To enhance patient comfort, the stimulation output of the stimulator can be slowly "ramped up" to its full stimulation power to allow the increase in stimulation to occur at various rates to accommodate the differing characteristics of different muscle groups. A jack is provided to permit the stimulation to be controlled by an external switch operated by a clinician to coordinate stimulation of various muscle groups with voluntary muscle contraction by the patient. The jack can also be connected to a heel operated switch to stimulate muscle groups to allow certain disabled persons to walk normally.
    Type: Grant
    Filed: March 13, 1981
    Date of Patent: July 12, 1983
    Assignee: Medtronic, Inc.
    Inventor: David J. Stanton
  • Patent number: 4230121
    Abstract: An electrical body stimulator having particular utility for transcutaneous electronic nerve stimulation. Circuitry is provided which delivers a driving pulse, the stimulator output circuitry being responsive to the driving pulse duration for establishing at least one stimulation signal parameter in accordance therewith. In a preferred embodiment, the driving pulse generator includes an energy storage device and an oscillating power supply connected to the storage device for alternately charging and discharging the storage device. A dual state device responds to the charge level of the energy storage device and changes state in response to predetermined changes in the energy storage device charge level. The charging rate is alterable to alter the duration of the driving pulse.
    Type: Grant
    Filed: January 29, 1979
    Date of Patent: October 28, 1980
    Assignee: Medtronic, Inc.
    Inventor: David J. Stanton
  • Patent number: RE32091
    Abstract: A dual channel neuromuscular stimulator. Pulses developed by a pulse generator are transmitted alternately on both channels to involuntarily contract muscles. The stimulator has variable on/off cycling capability to provide flexibility in meeting the stimulation needs of patients and has output current adjustments and other variable parameter settings to achieve optimum neuromuscular stimulation. To enhance patient comfort, the stimulation output of the stimulator can be slowly "ramped up" to its full stimulation power to allow the increase in stimulation to occur at various rates to accommodate the differing characteristics of different muscle groups. A jack is provided to permit the stimulation to be controlled by an external switch operated by a clinician to coordinate stimulation of various muscle groups with voluntary muscle contraction by the patient. The jack can also be connected to a heel operated switch to stimulate muscle groups to allow certain disabled persons to walk normally.
    Type: Grant
    Filed: October 24, 1983
    Date of Patent: March 11, 1986
    Assignee: Medtronic, Inc.
    Inventor: David J. Stanton
  • Patent number: D359803
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: June 27, 1995
    Assignee: Medtronic, Inc.
    Inventors: David J. Stanton, Craig F. Borchard, Mark R. Bilitz