Patents by Inventor David J. Ternes
David J. Ternes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931580Abstract: An example of a method embodiment may include receiving a user programmable neural stimulation (NS) dose for an intermittent neural stimulation (INS) therapy, and delivering the INS therapy with the user programmable NS dose to an autonomic neural target of a patient. Delivering the INS therapy may include delivering NS bursts, and delivering the NS bursts may include delivering a number of NS pulses per cardiac cycle during a portion of the cardiac cycles and not delivering NS pulses during a remaining portion of the cardiac cycles. The method may further include sensing cardiac events within the cardiac cycles, and controlling delivery of the user programmable NS dose of INS therapy using the sensed cardiac events to time delivery of the number of NS pulses per cardiac cycle to provide the user programmable NS dose. The user programmable NS dose may determine the number of NS pulses per cardiac cycle.Type: GrantFiled: July 30, 2019Date of Patent: March 19, 2024Assignee: Cardiac Pacemakers, Inc.Inventors: David J. Ternes, Jason J. Hamann, Stephen B. Ruble, Juan Gabriel Hincapie Ordonez, Manfred Franke
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Patent number: 11883664Abstract: Systems and methods for managing pain in patient are described. A system may include sensors configured to sense physiological or functional signals, and a pain analyzer to generate signal metrics from the physiological or functional signals. The pain analyzer also generates weight factors corresponding to the signal metrics. The weight factors may indicate the signal metrics reliability in representing an intensity of the pain. The pain analyzer generates a pain score using a plurality of signal metrics and a plurality of weight factors. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver closed-loop pain therapy according to the pain score.Type: GrantFiled: June 23, 2022Date of Patent: January 30, 2024Assignee: Boston Scientific Neuromodulation CorporationInventors: Pramodsingh Hirasingh Thakur, Jianwen Gu, Bryan Allen Clark, David J. Ternes, David L. Perschbacher, James John Kleinedler, Elizabeth Mary Annoni
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Patent number: 11751804Abstract: An example of a system for managing pain may include a pain monitoring circuit, a pain relief device, and a control circuit. The pain monitoring circuit may include a parameter analyzer and a pain score generator. The parameter analyzer may be configured to receive and analyze at least two parameters selected from a physiological parameter indicative of a physiological function or state of a patient, a functional parameter indicative of a physical activity or state of the patient, or a patient parameter including subjective information provided by the patient. The pain score generator may be configured to compute a composite pain score using an outcome of the analysis. The composite pain score may indicate a degree of the pain. The pain relief device may be configured to deliver a pain-relief therapy. The control circuit may be configured to control the delivery of the pain-relief therapy using the composite pain score.Type: GrantFiled: August 6, 2020Date of Patent: September 12, 2023Assignee: Boston Scientific Neuromodulation CorporationInventors: Elizabeth Mary Annoni, Bryan Allen Clark, Pramodsingh Hirasingh Thakur, Jianwen Gu, James John Kleinedler, Kyle Harish Srivastava, David J. Ternes, David L. Perschbacher, Rosana Esteller
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Patent number: 11666749Abstract: An implantable antibacterial barrier device for an elongated medical device, the elongated medical device configured to extend from a first site, through a second site, to a third site. The implantable antibacterial barrier device includes a housing configured to be disposed at the first site, a working electrode configured to be disposed at the second site, and a reference electrode configured to be disposed at the first site. The housing includes barrier circuitry. The working electrode electrically is coupled to the barrier circuitry. The reference electrode is electrically coupled to the barrier circuitry. The barrier circuitry is configured to selectively maintain the working electrode at a negative electrical potential relative to the reference electrode to form an antibacterial barrier.Type: GrantFiled: October 21, 2020Date of Patent: June 6, 2023Assignee: Cardiac Pacemakers, Inc.Inventors: Jeffrey E. Stahmann, Keith R. Maile, Danielle Frankson, Craig M. Stolen, David J. Ternes
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Publication number: 20230149716Abstract: A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.Type: ApplicationFiled: January 13, 2023Publication date: May 18, 2023Inventors: Juan Gabriel Hincapie Ordonez, David J. Ternes, Jason J. Hamann, Stephen B. Ruble
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Publication number: 20230122366Abstract: Systems and methods for managing heart failure are described. The system receives physiological information including a first HS signal corresponding to paced ventricular contractions and a second HS signal corresponding to intrinsic ventricular contractions. The system detects worsening heart failure (WHF) using the received physiological information. A signal analyzer circuit can generate a paced HS metric from the first HS signal and a sensed HS metric from the second HS signal, and determine a concordance indicator between the paced and the sensed HS metrics. In response to the detected WHF, the system can use the concordance indicator to generate a therapy adjustment indicator for adjusting electrostimulation therapy, or a worsening cardiac contractility indicator indicating the detected WHF is attributed to degrading myocardial contractility.Type: ApplicationFiled: December 19, 2022Publication date: April 20, 2023Inventors: Pramodsingh Hirasingh Thakur, Jason Humphrey, David J. Ternes, Qi An, Krzysztof Z. Siejko, Michael James Dufresne, Yinghong Yu
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Publication number: 20230103473Abstract: Systems and methods for monitoring physiologic response to Valsalva maneuver (VM) are disclosed. An exemplary patient monitor may detect a natural incidence of a VM session occurred in an ambulatory setting using a heart sound (HS) signal sensed from the patient. The patient monitor may include a physiologic response analyzer to sense patient physiologic response during the detected VM session, and generate a cardiovascular or autonomic function indicator based on the sensed physiologic response to the VM. Using the physiologic response to the VM, the system may detect a target physiologic event using the sensed physiologic response to the VM.Type: ApplicationFiled: December 5, 2022Publication date: April 6, 2023Inventors: Pramodsingh Hirasingh Thakur, David J. Ternes, Ashley Moriah Jensen, Qi An, Amy Jean Brisben
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Patent number: 11577083Abstract: A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.Type: GrantFiled: February 2, 2021Date of Patent: February 14, 2023Assignee: Cardiac Pacemakers, Inc.Inventors: Juan Gabriel Hincapie Ordonez, David J. Ternes, Jason J. Hamann, Stephen B. Ruble
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Publication number: 20230038324Abstract: Systems and methods for monitoring and treating patients with heart failure (HF) are discussed. The system may sense cardiac signals, and receives information about patient physiological or functional conditions. A stimulation parameter table that includes recommended values of atrioventricular delay (AVD) or other timing parameters may be created at a multitude of patient physiological or functional conditions. The system may periodically reassess patient physiological or functional conditions. A therapy programmer circuit may dynamically switch between left ventricular-only pacing and biventricular pacing, or switch between single site pacing and multisite pacing based on the patient condition. The therapy programmer circuit may adjust AVD and other timing parameters using the cardiac signal input and the stored stimulation parameter table. A HF therapy may be delivered according to the determined stimulation site, stimulation mode, and the stimulation timing.Type: ApplicationFiled: October 19, 2022Publication date: February 9, 2023Inventors: David J. Ternes, Yinghong Yu, Jason Humphrey, David L. Perschbacher, Michael James Dufresne, Adam MacEwen, Keith L. Herrmann
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Patent number: 11541242Abstract: Systems and methods for managing heart failure are described. The system receives physiological information including a first HS signal corresponding to paced ventricular contractions and a second HS signal corresponding to intrinsic ventricular contractions. The system detects worsening heart failure (WHF) using the received physiological information. A signal analyzer circuit can generate a paced HS metric from the first HS signal and a sensed HS metric from the second HS signal, and determine a concordance indicator between the paced and the sensed HS metrics. In response to the detected WHF, the system can use the concordance indicator to generate a therapy adjustment indicator for adjusting electrostimulation therapy, or a worsening cardiac contractility indicator indicating the detected WHF is attributed to degrading myocardial contractility.Type: GrantFiled: August 28, 2018Date of Patent: January 3, 2023Assignee: Cardiac Pacemakers, Inc.Inventors: Pramodsingh Hirasingh Thakur, Jason Humphrey, David J. Ternes, Qi An, Krzysztof Z. Siejko, Michael James Dufresne, Yinghong Yu
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Patent number: 11523743Abstract: Systems and methods for monitoring physiologic response to Valsalva maneuver (VM) are disclosed. An exemplary patient monitor may detect a natural incidence of a VM session occurred in an ambulatory setting using a heart sound (HS) signal sensed from the patient. The patient monitor may include a physiologic response analyzer to sense patient physiologic response during the detected VM session, and generate a cardiovascular or autonomic function indicator based on the sensed physiologic response to the VM. Using the physiologic response to the VM, the system may detect a target physiologic event using the sensed physiologic response to the VM.Type: GrantFiled: July 18, 2019Date of Patent: December 13, 2022Assignee: Cardiac Pacemakers, Inc.Inventors: Pramodsingh Hirasingh Thakur, David J. Ternes, Ashley Moriah Jensen, Qi An, Amy Jean Brisben
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Patent number: 11497918Abstract: Systems and methods for monitoring and treating patients with heart failure (HF) are discussed. The system may sense cardiac signals, and receives information about patient physiological or functional conditions. A stimulation parameter table that includes recommended values of atrioventricular delay (AVD) or other timing parameters maybe created at a multitude of patient physiological or functional conditions. The system may periodically reassess patient physiological or functional conditions. A therapy programmer circuit may dynamically switch between left ventricular-only pacing and biventricular pacing, or switch between single site pacing and multisite pacing based on the patient condition. The therapy programmer circuit may adjust AVD and other timing parameters using the cardiac signal input and the stored stimulation parameter table. A HF therapy may be delivered according to the determined stimulation site, stimulation mode, and the stimulation timing.Type: GrantFiled: June 13, 2018Date of Patent: November 15, 2022Assignee: Cardiac Pacemakers, Inc.Inventors: David J. Ternes, Yinghong Yu, Jason Humphrey, David L. Perschbacher, Michael James Dufresne, Adam MacEwen, Keith L. Herrmann
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Publication number: 20220323760Abstract: Systems and methods for managing pain in patient are described. A system may include sensors configured to sense physiological or functional signals, and a pain analyzer to generate signal metrics from the physiological or functional signals. The pain analyzer also generates weight factors corresponding to the signal metrics. The weight factors may indicate the signal metrics reliability in representing an intensity of the pain. The pain analyzer generates a pain score using a plurality of signal metrics and a plurality of weight factors. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver closed-loop pain therapy according to the pain score.Type: ApplicationFiled: June 23, 2022Publication date: October 13, 2022Inventors: Pramodsingh Hirasingh Thakur, Jianwen Gu, Bryan Allen Clark, David J. Ternes, David L. Perschbacher, James John Kleinedler, Elizabeth Mary Annoni
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Patent number: 11446499Abstract: Systems and methods for managing pain in patient are described. A system may include sensors configured to sense physiological or functional signals, and a pain analyzer to generate signal metrics from the physiological or functional signals. The pain analyzer also generates weight factors corresponding to the signal metrics. The weight factors may indicate the signal metrics reliability in representing an intensity of the pain. The pain analyzer generates a pain score using a plurality of signal metrics and a plurality of weight factors. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver closed-loop pain therapy according to the pain score.Type: GrantFiled: February 25, 2020Date of Patent: September 20, 2022Assignee: Boston Scientific Neuromodulation CorporationInventors: Pramodsingh Hirasingh Thakur, Jianwen Gu, Bryan Allen Clark, David J. Ternes, David L. Perschbacher, James John Kleinedler, Elizabeth Mary Annoni
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Patent number: 11395625Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system may include a motion sensor configured to sense at least one functional signal indicative a physical state of the subject. The at least one functional signal may include at least one motor activity signal or at least one sleep state signal. A pain analyzer circuit may extract, from the functional signal, signal metrics indicative of subject motor control or kinetics, and generate a pain score using the signal metrics. The pain score may be output to a user or a process. The system may additionally include an electrostimulator to generate and deliver a closed-loop pain therapy according to the pain score.Type: GrantFiled: March 17, 2020Date of Patent: July 26, 2022Assignee: Boston Scientific Neuromodulation CorporationInventors: Bryan Allen Clark, Elizabeth Mary Annoni, Jianwen Gu, Kyle Harish Srivastava, Pramodsingh Hirasingh Thakur, James John Kleinedler, David J. Ternes
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Patent number: 11337646Abstract: An example of a system for providing a patient with pain management includes a pain monitoring circuit. The pain monitoring circuit may include parameter analyzer circuitry and pain score generator circuitry. The parameter analyzer circuitry may be configured to receive and analyze one or more timing parameters and one or more baroreflex parameters allowing for determination of baroreflex sensitivity (BRS) of the patient. The one or more timing parameters are indicative of time intervals during which values of the one or more baroreflex parameters are used to determine the BRS. The pain score generator circuitry may be configured to compute a pain score using an outcome of the analysis. The pain score is a function of the BRS during the time intervals and indicative of a degree of pain of the patient.Type: GrantFiled: March 16, 2020Date of Patent: May 24, 2022Assignee: Boston Scientific Neuromodulation CorporationInventors: Elizabeth Mary Annoni, Pramodsingh Hirasingh Thakur, Bryan Allen Clark, Kyle Harish Srivastava, Jianwen Gu, James John Kleinedler, David J. Ternes, David L. Perschbacher
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Patent number: 11273306Abstract: An apparatus comprises a stimulus circuit, a recharge circuit, a switch circuit, and a control circuit. The stimulus circuit provides electrical cardiac pacing stimulation to multiple combinations of a plurality of electrodes, and the electrical stimulation is selectively applied at the first electrode of the electrode combinations. The recharge circuit includes a recharge capacitor electrically coupled to the second electrode of the electrode combinations, and the switch circuit selectively enables electrode combinations for electrical coupling to the stimulus circuit and the recharge circuit. The control circuit includes a pacing activation sub-circuit that selectively initiates delivery of the electrical stimulation using multiple electrode combinations, and enables simultaneous delivery of pacing recharge energy from the recharge capacitor to the second electrode of multiple electrode combinations.Type: GrantFiled: October 2, 2019Date of Patent: March 15, 2022Assignee: Cardiac Pacemakers, Inc.Inventors: David J. Ternes, William J. Linder
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Patent number: 11207523Abstract: Systems and methods for pacing cardiac conductive tissue are described. An exemplary system includes an electrostimulation circuit that may generate HBP pulses to stimulate patient physiologic conduction pathway, such as a His bundle or a bundle branch. The system includes an arrhythmia detector to detect an atrial tachyarrhythmia (AT) with intermittent ventricular conduction. A control circuit may sense ventricular activation and, in response to the detected AT indication, determine or update a His-bundle pacing (HBP) configuration. The HBP may be recursively updated on a beat-by-beat basis using the sensed ventricular activation. The electrostimulation circuit may deliver HBP according to the determined or adjusted HBP configuration to regularize ventricular rate during AT.Type: GrantFiled: November 21, 2019Date of Patent: December 28, 2021Assignee: Cardiac Pacemakers, Inc.Inventors: David J. Ternes, Deepa Mahajan, Keith L. Herrmann
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Patent number: 11207528Abstract: Systems and methods for dynamically controlling HBP delivery based on patient AV conduction status are disclosed. An exemplary medical system includes an electrostimulation circuit to generate HBP pulses to stimulate a His bundle or a bundle branch of the heart. An AV conduction monitor circuit continuously or periodically assesses AV conduction status, and detects an indication of presence or absence of AV conduction abnormality. If an AV conduction abnormality is indicated, a control circuit may control the electrostimulation circuit to deliver the HBP pulses. Ventricular backup pacing may be delivered if HBP fails to capture and elicit ventricular activation. When the AV conduction become normal, the control circuit may withhold HBP delivery and promote patient intrinsic ventricular activation.Type: GrantFiled: December 9, 2019Date of Patent: December 28, 2021Assignee: Cardiac Pacemakers, Inc.Inventors: David J. Ternes, Deepa Mahajan
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Patent number: 11202601Abstract: This document discusses, among other things, systems and methods for monitoring a patient at risk of epilepsy. A system comprises a sensor circuit that senses from the patient at least first and second physiological or functional signals. A wellness detector circuit can detect an epileptic event using the sensed physiological or functional signals, or additionally classify the epileptic event into one of epileptic seizure types. The system can generate a wellness indicator based on a trend of the physiological or functional signal during the detected epileptic event. The wellness indicator indicates an impact of the detected epileptic event on the health status of the patient. The system includes an output unit configured to output the detection of the epileptic event or the wellness indicator to a user or a process.Type: GrantFiled: November 28, 2017Date of Patent: December 21, 2021Assignee: Cardiac Pacemakers, Inc.Inventors: David J. Ternes, Pramodsingh Hirasingh Thakur, Qi An, Amy Jean Brisben, Stephen B. Ruble, Keith R. Maile