Abstract: Systems and methods for optimizing detection of optical signals indicating the presence of an analyte of interest in a blood sample are described. In one aspect, a blood culture test vial having a sensor is inoculated with the blood sample, light at an excitation frequency of the sensor is transmitted to the test vial, an intensity of a plurality of fluorescence signals emitted from the test vial is measured, and the plurality of measured fluorescence signals are normalized using by a reference signal that is not dependent on a measured intensity of a fluorescence signal emitted from the test vial. In another aspect, a measurement system measures fluorescence signals from one or more reference vials performing in extreme pH conditions. Fluorescence signals emitted from test vials inoculated with samples under test are measured and compared to the signals measured from the one or more reference vials to address or mitigate variability in hardware components of the measurement system.

Abstract: A risk relationship data store contains electronic records that represent, for risk relationships with an enterprise: a risk relationship identifier, an autonomous machine identifier, at least one attribute value, and a resource amount. A device located proximate to an autonomous machine includes an interface for an entity associated with the autonomous machine and a transmitter to transmit a request signal generated via the interface. A back-end application computer server associates the request signal with a specific future operation of the autonomous machine and forwards information about the specific future operation to a remote risk relationship platform. The computer server then receives information about a potential risk relationship with another enterprise and transmits a risk relationship offer to the device located proximate to the autonomous machine. Responsive to an agreement signal received from the device located proximate to the autonomous machine, the risk relationship data store is updated.

Abstract: A computer server may receive an indication of a selected potential relationship and retrieve, from a use case configuration data store, an electronic record for that relationship. The first entity may then construct computer system configurations in accordance with use case parameters. The computer server may be used to evaluate the constructed computer system configurations, and an entity score result for the first entity may be stored into the use case configuration data store. The computer server may also retrieve, from a quality function deployment data store, an electronic record associated with the first entity and update a uniform scoring matrix by assigning weighted score values for the first entity in connection with a set of platform capabilities. An entity selection tool may be executed to automatically select a recommended entity based on the score results and scoring matrixes, and an indication of the recommended entity may be transmitted.

Abstract: Some embodiments are directed to an emergency response system implemented via a back-end application computer server. A vehicle telematics data store may contain electronic records and each electronic record may include, for example, an electronic record identifier and at least one vehicle operation parameter (e.g., a vehicle speed, an accident location, an accident time of day, etc.). The computer server may receive, from an emergency responder (e.g., a police officer, ambulance, firefighter, etc.) via an interactive graphical emergency responder interface display, a vehicle tag (e.g., based on a QR code). The computer server may then retrieve, from the vehicle telematics data store, a vehicle operation parameter associated with the vehicle tag and update the display based on the retrieved a vehicle operation parameter associated with the vehicle tag.

Abstract: A computer server may receive an indication of a selected potential relationship and retrieve, from a use case configuration data store, an electronic record for that relationship. The first entity may then construct computer system configurations in accordance with use case parameters. The computer server may be used to evaluate the constructed computer system configurations, and an entity score result for the first entity may be stored into the use case configuration data store. The computer server may also retrieve, from a quality function deployment data store, an electronic record associated with the first entity and update a uniform scoring matrix by assigning weighted score values for the first entity in connection with a set of platform capabilities. An entity selection tool may be executed to automatically select a recommended entity based on the score results and scoring matrixes, and an indication of the recommended entity may be transmitted.

Abstract: Provided herein are compositions, methods, systems and/or kits for detection of bacteria expressing enzymes that confer resistance to antimicrobial agents. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of carbapenemase-producing gram negative bacteria. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of Ambler Class A, B and/or D carbapenemase-producing enteric and non-fermenting gram negative rod bacteria.

Abstract: A computer server may receive an indication of a selected potential relationship and retrieve, from a use case configuration data store, an electronic record for that relationship. The first entity may then construct computer system configurations in accordance with use case parameters. The computer server may be used to evaluate the constructed computer system configurations, and an entity score result for the first entity may be stored into the use case configuration data store. The computer server may also retrieve, from a quality function deployment data store, an electronic record associated with the first entity and update a uniform scoring matrix by assigning weighted score values for the first entity in connection with a set of platform capabilities. An entity selection tool may be executed to automatically select a recommended entity based on the score results and scoring matrixes, and an indication of the recommended entity may be transmitted.

Abstract: Provided herein are compositions, methods, systems and/or kits for detection of bacteria expressing enzymes that confer resistance to antimicrobial agents. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of carbapenemase-producing gram negative bacteria. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of Ambler Class A, B and/or D carbapenemase-producing enteric and non-fermenting gram negative rod bacteria.

Abstract: Provided herein are devices, systems, and methods for measuring the presence of an analyte of interest in a sample. Certain embodiments of the present disclosure are related to culture measurement systems that include a culture vial and a sensor, wherein the sensor is a pH sensor, a responsive label, or an indicator compound, such that the sensor is incorporated into the culture vial for measurement of the pH of the sample.

Abstract: A computer server may receive an indication of a selected potential relationship and retrieve, from a use case configuration data store, an electronic record for that relationship. The first entity may then construct computer system configurations in accordance with use case parameters. The computer server may be used to evaluate the constructed computer system configurations, and an entity score result for the first entity may be stored into the use case configuration data store. The computer server may also retrieve, from a quality function deployment data store, an electronic record associated with the first entity and update a uniform scoring matrix by assigning weighted score values for the first entity in connection with a set of platform capabilities. An entity selection tool may be executed to automatically select a recommended entity based on the score results and scoring matrixes, and an indication of the recommended entity may be transmitted.

Abstract: Systems and methods for optimizing detection of optical signals indicating the presence of an analyte of interest in a blood sample are described. In one aspect, a blood culture test vial having a sensor is inoculated with the blood sample, light at an excitation frequency of the sensor is transmitted to the test vial, an intensity of a plurality of fluorescence signals emitted from the test vial is measured, and the plurality of measured fluorescence signals are normalized using by a reference signal that is not dependent on a measured intensity of a fluorescence signal emitted from the test vial. In another aspect, a measurement system measures fluorescence signals from one or more reference vials performing in extreme pH conditions. Fluorescence signals emitted from test vials inoculated with samples under test are measured and compared to the signals measured from the one or more reference vials to address or mitigate variability in hardware components of the measurement system.

Abstract: Provided herein are compositions, methods, systems and/or kits for detection of bacteria expressing enzymes that confer resistance to antimicrobial agents. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of carbapenemase-producing gram negative bacteria. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of Ambler Class A, B and/or D carbapenemase-producing enteric and non-fermenting gram negative rod bacteria.

Abstract: A system for underwriting using civic improvement platform based data is disclosed. In some embodiments, an automated insurance underwriting platform for rating and pricing insurance policies through the accessing and evaluating of civic improvement platform based information is implemented. According to some embodiments, civic improvement platform data associated with a potential entity to be insured may be received. The civic improvement platform data may be, for example, associated with user safety reports received by a civic improvement platform. The civic improvement platform data may be analyzed, and an underwriting decision for the potential entity to be insured may be made based at least in part on said civic improvement platform data. The underwriting decision may be associated with, for example, a premium for an insurance policy, a benefit for an insurance policy, an insurance policy renewal, and/or an insurance policy premium adjustment.

Abstract: The embodiments of this invention provide a test panel and method for the detection of inducible resistance to macrolide-lincosamide-streptogramin b (iMLSb) in microorganisms in an automated microorganism identification (ID) and antimicrobial susceptibility determinations (AST) system. The wells of a multiple-well test panel contain a macrolide agent and a lincosamide agent and a combination of both macrolide agent and lincosamide agent. The test panel is inoculated with a broth-suspended microorganism, and placed into the automated microorganism identification (ID) and antimicrobial susceptibility determinations (AST) system. The test panel is incubated within the system and the wells monitored for microorganism growth.

Abstract: A system and method for analyzing samples, such as biological samples, to accurately and effectively determine the susceptibility of the samples to antimicrobial materials, so as to determine minimum inhibitory concentration (MIC) values for the respective samples and antimicrobial materials. At each of a plurality of time intervals, the system and method directs a plurality of different analyzing light wavelengths, such as red, green and blue wavelengths, onto each of a plurality of sample wells, and detects a respective resultant light wavelength emanating from the respective sample wells for each of the analyzing light wavelengths. The system and method uses resultant light wavelengths to generate at least two growth indicator characteristic curves representing, for example, the redox state and turbidity characteristics of the sample wells.

Abstract: A system and method for analyzing samples, such as biological samples, to accurately and effectively determine the susceptibility of the samples to antimicrobial materials, so as to determine minimum inhibitory concentration (MIC) values for the respective samples and antimicrobial materials. At each of a plurality of time intervals, the system and method directs a plurality of different analyzing light wavelengths, such as red, green and blue wavelengths, onto each of a plurality of sample wells, and detects a respective resultant light wavelength emanating from the respective sample wells for each of the analyzing light wavelengths. The system and method uses resultant light wavelengths to generate at least two growth indicator characteristic curves representing, for example, the redox state and turbidity characteristics of the sample wells.

Abstract: A rotor assembly including first and second generally discoidal endshafts disposed at opposite ends of the rotor assembly, an electromagnetic core and winding assembly secured between the endshafts, and a generally annular sleeve member shrunk-fit onto the end shafts in a position surrounding the electromagnetic core and winding assembly. The torque is transmitted through the sleeve member between the endshafts during operation of the dynamoelectric device in which the rotor is employed. A method of assembling the rotor is also disclosed in which the electromagnetic core and winding assembly is bolted between the endshafts. The sleeve member is heated to a temperature between 900.degree. and 1,000.degree. F., the sleeve member is brought into a position over the endshafts, and subsequently allow to cool to ambient temperature to shrink into locking engagement with the endshafts.