Abstract: A calibrator bottle and method of calibration. The calibrator bottle includes a plastic material that is doped or compounded with a fluorescent material system that fluoresces in a target range and may be used to calibrate a blood culture instrument that measures sample fluorescence to determine bottle positivity or negativity. Also described herein is a system and method to control the temperature of samples in a blood culture apparatus using a resistance temperature device (RTD) device that measures the temperature of the sample. The sample measurements are correlated with the ambient temperature to determine an ambient temperature that will provide a target bottle content temperature.

Abstract: Provided herein are compositions, methods, systems and/or kits for detection of bacteria expressing enzymes that confer resistance to antimicrobial agents. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of carbapenemase-producing gram negative bacteria. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of Ambler Class A, B and/or D carbapenemase-producing enteric and non-fermenting gram negative rod bacteria.

Abstract: A method of determining the presence of an analyte of interest in a blood sample within a test device including a sensor in aqueous media includes transmitting light to the test device at a first excitation wavelength at which light absorption of the sensor remains substantially constant as pH of the aqueous media changes, measuring an intensity of a first fluorescence signal emitted from the sensor in the test device in response to the first excitation wavelength, transmitting light to the test device at a second excitation wavelength, the second excitation wavelength being different from the first excitation wavelength, measuring an intensity of a second fluorescence signal emitted from the sensor in the test device in response to the second excitation wavelength, and normalizing, with the first fluorescence signal, the intensity of the second fluorescence signal emitted from the test device in response to the second excitation wavelength.

Abstract: Some embodiments are directed to an emergency response system implemented via a back-end application computer server. A vehicle telematics data store may contain electronic records and each electronic record may include, for example, an electronic record identifier and at least one vehicle operation parameter (e.g., a vehicle speed, an accident location, an accident time of day, etc.). The computer server may receive, from an emergency responder (e.g., a police officer, ambulance, firefighter, etc.) via an interactive graphical emergency responder interface display, a vehicle tag (e.g., based on a QR code). The computer server may then retrieve, from the vehicle telematics data store, a vehicle operation parameter associated with the vehicle tag and update the display based on the retrieved a vehicle operation parameter associated with the vehicle tag.

Abstract: Some embodiments are directed to an emergency response system implemented via a back-end application computer server. A vehicle telematics data store may contain electronic records and each electronic record may include, for example, an electronic record identifier and at least one vehicle operation parameter (e.g., a vehicle speed, an accident location, an accident time of day, etc.). The computer server may receive, from an emergency responder (e.g., a police officer, ambulance, firefighter, etc.) via an interactive graphical emergency responder interface display, a vehicle tag (e.g., based on a QR code). The computer server may then retrieve, from the vehicle telematics data store, a vehicle operation parameter associated with the vehicle tag and update the display based on the retrieved a vehicle operation parameter associated with the vehicle tag.

Abstract: A system may include a training candidate data store containing electronic records. Each record may include a training candidate identifier and a set of candidate parameters. A training candidate evaluation tool receives, from a remote evaluation device, an indication of a selected training candidate. The tool may then retrieve information about the selected training candidate and automatically calculate, using at least some of the candidate parameters, an enterprise data analyst training score for the selected training candidate. The tool may then transmit the enterprise data analyst training score to a remote evaluation device and receive an indication of acceptance. The enterprise data analyst training score and set of candidate parameters may then be stored in a result data store, and a training workflow may be automatically assigned to the selected training candidate in accordance with the enterprise data analyst training score and enterprise logic.

Abstract: The invention relates to a method of enhancing cytotoxic T lymphocyte (CTL) activation and/or proliferation comprising inhibiting or reducing the activity of one or more post-transcriptional regulators of gene expression. Examples of such post-transcriptional regulators include RNA-binding proteins. Also provided is a CTL with enhanced activity and/or proliferative capacity obtainable by the methods defined herein, and a method of treating a disease or disorder in a subject in need thereof comprising administering said CTL with enhanced activity and/or proliferative capacity.

Abstract: Systems and methods for optimizing detection of optical signals indicating the presence of an analyte of interest in a blood sample are described. In one aspect, a blood culture test vial having a sensor is inoculated with the blood sample, light at an excitation frequency of the sensor is transmitted to the test vial, an intensity of a plurality of fluorescence signals emitted from the test vial is measured, and the plurality of measured fluorescence signals are normalized using by a reference signal that is not dependent on a measured intensity of a fluorescence signal emitted from the test vial. In another aspect, a measurement system measures fluorescence signals from one or more reference vials performing in extreme pH conditions. Fluorescence signals emitted from test vials inoculated with samples under test are measured and compared to the signals measured from the one or more reference vials to address or mitigate variability in hardware components of the measurement system.

Abstract: A risk relationship data store contains electronic records that represent, for risk relationships with an enterprise: a risk relationship identifier, an autonomous machine identifier, at least one attribute value, and a resource amount. A device located proximate to an autonomous machine includes an interface for an entity associated with the autonomous machine and a transmitter to transmit a request signal generated via the interface. A back-end application computer server associates the request signal with a specific future operation of the autonomous machine and forwards information about the specific future operation to a remote risk relationship platform. The computer server then receives information about a potential risk relationship with another enterprise and transmits a risk relationship offer to the device located proximate to the autonomous machine. Responsive to an agreement signal received from the device located proximate to the autonomous machine, the risk relationship data store is updated.

Abstract: A computer server may receive an indication of a selected potential relationship and retrieve, from a use case configuration data store, an electronic record for that relationship. The first entity may then construct computer system configurations in accordance with use case parameters. The computer server may be used to evaluate the constructed computer system configurations, and an entity score result for the first entity may be stored into the use case configuration data store. The computer server may also retrieve, from a quality function deployment data store, an electronic record associated with the first entity and update a uniform scoring matrix by assigning weighted score values for the first entity in connection with a set of platform capabilities. An entity selection tool may be executed to automatically select a recommended entity based on the score results and scoring matrixes, and an indication of the recommended entity may be transmitted.

Abstract: Some embodiments are directed to an emergency response system implemented via a back-end application computer server. A vehicle telematics data store may contain electronic records and each electronic record may include, for example, an electronic record identifier and at least one vehicle operation parameter (e.g., a vehicle speed, an accident location, an accident time of day, etc.). The computer server may receive, from an emergency responder (e.g., a police officer, ambulance, firefighter, etc.) via an interactive graphical emergency responder interface display, a vehicle tag (e.g., based on a QR code). The computer server may then retrieve, from the vehicle telematics data store, a vehicle operation parameter associated with the vehicle tag and update the display based on the retrieved a vehicle operation parameter associated with the vehicle tag.

Abstract: A computer server may receive an indication of a selected potential relationship and retrieve, from a use case configuration data store, an electronic record for that relationship. The first entity may then construct computer system configurations in accordance with use case parameters. The computer server may be used to evaluate the constructed computer system configurations, and an entity score result for the first entity may be stored into the use case configuration data store. The computer server may also retrieve, from a quality function deployment data store, an electronic record associated with the first entity and update a uniform scoring matrix by assigning weighted score values for the first entity in connection with a set of platform capabilities. An entity selection tool may be executed to automatically select a recommended entity based on the score results and scoring matrixes, and an indication of the recommended entity may be transmitted.

Abstract: Provided herein are compositions, methods, systems and/or kits for detection of bacteria expressing enzymes that confer resistance to antimicrobial agents. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of carbapenemase-producing gram negative bacteria. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of Ambler Class A, B and/or D carbapenemase-producing enteric and non-fermenting gram negative rod bacteria.

Abstract: A computer server may receive an indication of a selected potential relationship and retrieve, from a use case configuration data store, an electronic record for that relationship. The first entity may then construct computer system configurations in accordance with use case parameters. The computer server may be used to evaluate the constructed computer system configurations, and an entity score result for the first entity may be stored into the use case configuration data store. The computer server may also retrieve, from a quality function deployment data store, an electronic record associated with the first entity and update a uniform scoring matrix by assigning weighted score values for the first entity in connection with a set of platform capabilities. An entity selection tool may be executed to automatically select a recommended entity based on the score results and scoring matrixes, and an indication of the recommended entity may be transmitted.

Abstract: Provided herein are compositions, methods, systems and/or kits for detection of bacteria expressing enzymes that confer resistance to antimicrobial agents. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of carbapenemase-producing gram negative bacteria. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of Ambler Class A, B and/or D carbapenemase-producing enteric and non-fermenting gram negative rod bacteria.

Abstract: Provided herein are devices, systems, and methods for measuring the presence of an analyte of interest in a sample. Certain embodiments of the present disclosure are related to culture measurement systems that include a culture vial and a sensor, wherein the sensor is a pH sensor, a responsive label, or an indicator compound, such that the sensor is incorporated into the culture vial for measurement of the pH of the sample.

Abstract: A computer server may receive an indication of a selected potential relationship and retrieve, from a use case configuration data store, an electronic record for that relationship. The first entity may then construct computer system configurations in accordance with use case parameters. The computer server may be used to evaluate the constructed computer system configurations, and an entity score result for the first entity may be stored into the use case configuration data store. The computer server may also retrieve, from a quality function deployment data store, an electronic record associated with the first entity and update a uniform scoring matrix by assigning weighted score values for the first entity in connection with a set of platform capabilities. An entity selection tool may be executed to automatically select a recommended entity based on the score results and scoring matrixes, and an indication of the recommended entity may be transmitted.

Abstract: Systems and methods for optimizing detection of optical signals indicating the presence of an analyte of interest in a blood sample are described. In one aspect, a blood culture test vial having a sensor is inoculated with the blood sample, light at an excitation frequency of the sensor is transmitted to the test vial, an intensity of a plurality of fluorescence signals emitted from the test vial is measured, and the plurality of measured fluorescence signals are normalized using by a reference signal that is not dependent on a measured intensity of a fluorescence signal emitted from the test vial. In another aspect, a measurement system measures fluorescence signals from one or more reference vials performing in extreme pH conditions. Fluorescence signals emitted from test vials inoculated with samples under test are measured and compared to the signals measured from the one or more reference vials to address or mitigate variability in hardware components of the measurement system.

Abstract: Provided herein are compositions, methods, systems and/or kits for detection of bacteria expressing enzymes that confer resistance to antimicrobial agents. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of carbapenemase-producing gram negative bacteria. Certain embodiments of the compositions, methods, systems and/or kits of the present disclosure are related to detection of Ambler Class A, B and/or D carbapenemase-producing enteric and non-fermenting gram negative rod bacteria.

Abstract: A system for underwriting using civic improvement platform based data is disclosed. In some embodiments, an automated insurance underwriting platform for rating and pricing insurance policies through the accessing and evaluating of civic improvement platform based information is implemented. According to some embodiments, civic improvement platform data associated with a potential entity to be insured may be received. The civic improvement platform data may be, for example, associated with user safety reports received by a civic improvement platform. The civic improvement platform data may be analyzed, and an underwriting decision for the potential entity to be insured may be made based at least in part on said civic improvement platform data. The underwriting decision may be associated with, for example, a premium for an insurance policy, a benefit for an insurance policy, an insurance policy renewal, and/or an insurance policy premium adjustment.