Patents by Inventor David J. Waxman

David J. Waxman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy
    Patent number: 6207648
    Abstract: Methods of killing neoplastic cells are provided. The invention relates to the use of NADPH-cytochrome P450 reductase (RED) gene transfer in combination with cytochrome P450 gene transfer to enhance the sensitivity of tumor cells to anti-cancer drugs that are activated by P450 enzymes. The use of bioreductive drugs that are activated by RED and/or cytochrome P450, in this paradigm, is also provided.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: March 27, 2001
    Assignee: Trustees of Boston University
    Inventors: David J. Waxman, Ling Chen
  • Method of selectively destroying neoplastic cells
    Patent number: 5688773
    Abstract: A method for selectively killing nervous system and peripheral neoplastic cells is provided. Viral vectors are used to selectively express a cytochrome P450 gene in neoplastic cells, whose gene product targets the cells for selective killing, by rendering the cells sensitive to a chemotherapeutic agent.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: November 18, 1997
    Assignees: The General Hospital Corporation, Boston University, Dana-Farber Cancer Institute
    Inventors: E. Antonio Chiocca, David J. Waxman, Ming X. Wei, Xandra O. Breakefield, Ling Chen