Abstract: Systems and methods are disclosed which employ a centralized selection context having selection states spread across user interface elements. Methods are described in which the binding between widgets and data storage is isolated using the centralized selection context paradigm for a majority of data items represented within a user interface. This selection context is fully accessible by methods that access data while considering the current selection context. The centralized selection context simplifies event-handling logic by having selection context readily available thus removing the need to query individual widgets for their state.

Abstract: Systems and methods are disclosed which employ a centralized selection context having selection states spread across user interface elements. Methods are described in which the binding between widgets and data storage is isolated using the centralized selection context paradigm for a majority of data items represented within a user interface. This selection context is fully accessible by methods that access data while considering the current selection context. The centralized selection context simplifies event-handling logic by having selection context readily available thus removing the need to query individual widgets for their state.

Abstract: We have discovered a target protein which is conserved in fungi and essential for cell viability, cell growth, the control of cell morphogenesis, and combinations thereof. An antifungal agent targets the protein in a fungus, but not an infected host. This protein is encoded by the bot1 gene in Schizosaccharomyces pombe, Saccharomyces cerevisiae, and Candida albicans but is not detected in a filamentous fungus.