Abstract: An automatic vehicle equipment control system and methods thereof are provided, the system includes at least one imager configured to acquire a continuous sequence of high dynamic range single frame images, a processor, a color spectral filter array including a plurality of color filters, at least a portion of which are different colors, and pixels of an imager pixel array being in optical communication with substantially one spectral color filter, and a lens, wherein the imager is configured to capture a non-saturated image of nearby oncoming headlamps and at least one of a diffuse lane marking and a distant tail lamp in one image frame of the continuous sequence of high dynamic range single frame images, and the system configured to detect at least one of said highway markings and said tail lamps, and quantify light from the oncoming headlamp from data in the one image frame.

Abstract: A classification system and method are provided, wherein the classification system includes a memory device, a processor communicatively connected to the memory device, and an input communicatively connected to the processor, wherein the input is configured to receive data comprising at least one object that is to be classified as one of an object of interest (OOI) and a nuisance of interest (NOI) based upon at least one non-Boolean attribute of the object, wherein the processor is configured as a Bayesian classifier to classify the object based upon the non-Boolean attribute using a non-linear probability function.

Abstract: An automatic vehicle equipment control system and methods thereof are provided, the system includes at least one imager configured to acquire a continuous sequence of high dynamic range single frame images, a processor, a color spectral filter array including a plurality of color filters, at least a portion of which are different colors, and pixels of an imager pixel array being in optical communication with substantially one spectral color filter, and a lens, wherein the imager is configured to capture a non-saturated image of nearby oncoming headlamps and at least one of a diffuse lane marking and a distant tail lamp in one image frame of the continuous sequence of high dynamic range single frame images, and the system configured to detect at least one of said highway markings and said tail lamps, and quantify light from the oncoming headlamp from data in the one image frame.

Abstract: An automatic vehicle equipment control system and methods thereof are provided, the system includes at least one imager configured to acquire a continuous sequence of high dynamic range single frame images, a processor, a color spectral filter array including a plurality of color filters, at least a portion of which are different colors, and pixels of an imager pixel array being in optical communication with substantially one spectral color filter, and a lens, wherein the imager is configured to capture a non-saturated image of nearby oncoming headlamps and at least one of a diffuse lane marking and a distant tail lamp in one image frame of the continuous sequence of high dynamic range single frame images, and the system configured to detect at least one of said highway markings and said tail lamps, and quantify light from the oncoming headlamp from data in the one image frame.

Abstract: A method of assisting a subject to swallow an object such as a solid pharmaceutical dosage form comprises providing on the object an at least partial surface covering comprising a lubricating edible gel composition.

Abstract: The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived therefrom, and their use as analyte biosensors both in vitro and in vivo.

Abstract: The present invention provides methods for detecting and identifying sequence variations in a nucleic acid sequence of interest using a detector primer. It has been found that the reduced efficiency of primer extension by DNA polymerases when the 3? end of a primer does not hybridize perfectly with the target can be adapted for use as a means for distinguishing or identifying the nucleotide in the target which is at the site where the diagnostic mismatch between the detector primer and the target occurs. The detector primer hybridizes to the sequence of interest and is extended with polymerase. The efficiency of detector primer extension is detected as an indication of the presence and/or identity of the sequence variation in the target. The inventive methods make use of nucleotide mismatches at or near the 3? end of the detector primer to discriminate between the nucleotide sequence of interest and a second nucleotide sequence which may occur at that same site in the target.

Abstract: Apparatus for interactively generating a display signal. The apparatus comprises: a receiver (2) for receiving a broadcast signal (15), the broadcast signal comprising a plurality of datastreams each including image data defining a background object (22–270), and control parameters (28–39); a foreground computer generated imagery (CGI) device (3) for generating a foreground computer generated object (CGO); a mixer (4) for combining the foreground CGO with background object image data to generate the display signal; and interaction means (3) for receiving the control parameters from the receiver, monitoring the position of the foreground CGO, and adapting the display signal with reference to the monitored position of the foreground CGO and the received control parameters.

Abstract: The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived there from, and their use as analyte biosensor both in vitro and in vivo.

Abstract: A system (10) for reducing volume of material used in laboratory processes, including a low-volume micro-plate (70,80) having a number of wells (14) bound together with matrix material (16), where the wells include secondary wells (74, 84) having reduced volume, and volume limiting plugs (20). The volume limiting plugs (20) have a shank portion (30) and a tip portion (28), where the shank and tip portions (20,30) are configured to extends a substantial distance into a well (14) of the multi-well plate (70,80) to reduce the volume of the well. Also volume limiting plugs (20) for use with standard multi-well plates and low-volume micro-plates (70,80) for use with standard plugs.

Abstract: The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived there from, and their use as analyte biosensor both in vitro and in vivo.

Abstract: An improved multi-well synthesis and filtration apparatus (10) includes a deep-well synthesis block (12) having a plurality of flowthrough wells (24) optionally fitted with filter disks (48) each of the wells (24) being integrally formed in the synthesis block (12), such that any material placed in the wells (24) is in immediate contact with the material of the synthesis block (12), an upper cover (14), a lower cover (16), and a pair of first and second sheet gaskets (18, 20). The first and second sheet gaskets (18, 20) are interposed between the upper and lower covers (14, 16) to seal inlet portions (38) and outlet spouts (40) of the wells (24). The upper and lower covers (14, 16) are independently releasable, and, with the gaskets (18, 20) form a gas tight seal, so that material is retained in the wells (24) when the lower cover (16) is removed, but the upper seal maintained.

Abstract: An apparatus for multiple simultaneous synthesis (110), having a number of vials (28), each vial (28) having an upper end (31), a lower end (30), and a barrel (29), the upper end (31) opening into a mouth (32). It also includes a lower frame assembly (180) having a number of holes (101, 103, 105) for receiving the vials (28), and an upper frame assembly (180), which includes inner side-walls (195) and a ceiling portion (190). A gas-tight seal (197) surrounds a plenum (85), the plenum (85) being formed between the ceiling portion (190) of the upper frame assembly (180) and the lower frame assembly (181). The plenum (85) is adjustable in volume by the positioning of the upper frame assembly (180) in variable relation to the lower frame assembly (181), while maintaining the gas-tight seal (197). The volume of the plenum (85) is adjustable to a minimum whereby the mouths (32) of the vials (28) are sealed by the ceiling (190) of the gas-tight seal (197), which is optionally an upper gasket (90).

Abstract: A syringe with replaceable needle assembly (10), having a syringe barrel (18) with a proximal end (14), a distal end (16), and an outer surface (87). The syringe barrel (18) surrounds an internal bore (20). A plunger assembly (60) is inserted into the syringe barrel internal bore (20). A needle assembly (80) has a sealing portion (72), which is configured to be removably insertable into the internal bore (20). The sealing portion (72) forms a fluid-tight seal with the internal bore (20). The needle assembly (80) further includes a releasable locking mechanism (79), which includes a collar (76) having a locking flange (86). Also disclosed is a replaceable needle assembly (80), which releasably locks onto the outer surface (87) of the proximal end (14) of a syringe barrel (18).

Abstract: The present invention provides methods for detecting and identifying sequence variations in a nucleic acid sequence of interest using a detector primer. It has been found that the reduced efficiency of primer extension by DNA polymerases when the 3′ end of a primer does not hybridize perfectly with the target can be adapted for use as a means for distinguishing or identifying the nucleotide in the target which is at the site where the diagnostic mismatch between the detector primer and the target occurs. The detector primer hybridizes to the sequence of interest and is extended with polymerase. The efficiency of detector primer extension is detected as an indication of the presence and/or identity of the sequence variation in the target. The inventive methods make use of nucleotide mismatches at or near the 3′ end of the detector primer to discriminate between the nucleotide sequence of interest and a second nucleotide sequence which may occur at that same site in the target.

Abstract: The present invention provides methods for detecting and identifying sequence variations in a nucleic acid sequence of interest using a detector primer. It has been found that the reduced efficiency of primer extension by DNA polymerases when the 3′ end of a primer does not hybridize perfectly with the target can be adapted for use as a means for distinguishing or identifying the nucleotide in the target which is at the site where the diagnostic mismatch between the detector primer and the target occurs. The detector primer hybridizes to the sequence of interest and is extended with polymerase. The efficiency of detector primer extension is detected as an indication of the presence and/or identity of the sequence variation in the target. The inventive methods make use of nucleotide mismatches at or near the 3′ end of the detector primer to discriminate between the nucleotide sequence of interest and a second nucleotide sequence which may occur at that same site in the target.

Abstract: The present invention provides methods for detecting and identifying sequence variations in a nucleic acid sequence of interest using a detector primer. It has been found that the reduced efficiency of primer extension by DNA polymerases when the 3′ end of a primer does not hybridize perfectly with the target can be adapted for use as a means for distinguishing or identifying the nucleotide in the target which is at the site where the diagnostic mismatch between the detector primer and the target occurs. The detector primer hybridizes to the sequence of interest and is extended with polymerase. The efficiency of detector primer extension is detected as an indication of the presence and/or identity of the sequence variation in the target. The inventive methods make use of nucleotide mismatches at or near the 3′ end of the detector primer to discriminate between the nucleotide sequence of interest and a second nucleotide sequence which may occur at that same site in the target.

Abstract: A syringe array (10) for holding a plurality of syringes (12), each syringe having a barrel (14), a plunger (18) and a needle (16), the syringe array (10) including a distal assembly (50) which holds the plungers (18) of the plurality of syringes (12) and by which all of the plurality of plungers (18) are urged to move in unison, a pivot assembly (52) wherein a portion of each the barrels (14) of the plurality of syringes (12) is pivotally attached to a pivot (92, 94) and a proximal assembly (48) wherein each needle (16) of the plurality of syringes (12) is positioned with a controlled center-to-center spacing (100, 102) from each other. An adjusting portion (62, 64, 70) of the syringe array (10) is adjustable to controllably change the needle center-to-center spacing from a first spacing (100) to at least a second spacing (102) as the barrel portions (14) are allowed to rotate about the pivots (92, 94).

Abstract: A multi-well synthesis and filtration apparatus (10) dimensionally arrayed in a standard multi-well format for performing multiple chemical reactions includes a deep-well synthesis block (12) with flowthrough wells (24) fitted with filter disks (48), an upper cover (14), and a lower cover (16). First and second sheet gaskets (18 and 20) seal inlet portions (38) and outlet spouts (40) of the wells (24). An optional skirt (26) provides a site for the independently releasable attachment of the upper and lower covers (14 and 16) to the block (12) while maintaining the seal on the unreleased cover. An alternative synthesis apparatus (310) additionally includes a reinforcement assembly (372) to improve the clamping action of the covers (14 and 16) upon the synthesis block (12). A rotating carrier apparatus (200) and a modified oven assembly (202) are provided to enable agitation and heating of multiple synthesis blocks (12) simultaneously.

Abstract: A system comprises a structure editor, a structure library, an extractor and a user interface, which are stored in computer memory and create structures for recognizing patterns in computer text. The structure editor via the user interface enables a user to input a text string called a model pattern, and uses previously-created structures such as lexical category structures for parsing the model pattern into default definition items. Each default definition item includes attributes specifying the patterns recognizable by the definition item and relationships with other definition items. The structure editor enables and facilitates user modification of the default definition items by generating attribute choices for user selection and allowing a user to generate a new structure if none of the choices is adequate. The resulting definition items form a new definition of a new structure, which is stored in the structure library.