Abstract: The invention provides NUC-7738 (3?-deoxyadenosine-5?-O-[phenyl(benzyloxy-L-alaninyl)] phosphate), a phosphoramidate derivative of 3?-deoxyadenosine, for use in the treatment of a proliferative disease, such as cancer, by reducing the amount of extra-cellular PD-L1 protein (e.g. soluble PD-L1 or exosomal PD L1) and/or increasing the amount of OX40-L. The invention also relates to the use of NUC-7738 in combination with an immune oncology agent such as an immune checkpoint inhibitor.

Abstract: A system uses a hybrid key-value storage engine that uses log-structured merge tree and a segmented log-structured object store. The system performs garbage collection of stale document versions avoiding index lookup during log segment compaction. The system separates index and document data to minimize write amplification. The system maintains a delete list using a log-structured merge-tree to store stale document sequence numbers and corresponding sizes per log segment. For each log segment from the plurality of log segments, the system determines a measure of fragmentation of the log segment based on sizes of deleted documents of the log segment from the second log-structured merge-tree. If the fragmentation exceeds a threshold, the system initiates a compaction operation for the log segment.

Abstract: A text classification command line interface tool assists a user label a dataset. The command line interface tool comprises a plurality of top-level modules programmed and operable to assist a user to obtain the dataset from a file location, semi-automatically search and label select datapoints of the dataset, train a first label-assist model, compute confidence scores for each of the datapoints of the dataset, and review metrics. The command line interface tool is operable to assist a user to retrain the first label-assist model via reinforcement learning until accuracy is sufficient. The CLI tool can save and export the pre-processed labeled dataset. In embodiments, a production classifier is trained using the preprocessed dataset and operable to classify new datapoints in real time. Examples of datapoints to classify include without limitation entity websites. Examples of categories include, without limitation, SHAFT and cannabis-related categories. Related computer-implemented methods are also described.

Abstract: A system and method for allowing a multiplicity of people to concurrently share a common video-audio device. A multiplicity of pixels comprising a common display are spatially divisible for outputting distinctly selected content, where the spatial divisions are substantially collocated with distinct physical locations amongst a multiplicity of possible locations. When a person walks up or is summoned to approach a specific physical location their presence is detected along with some identifier, where the person is then provided a selected video-audio stream output on the spatially relevant pixels corresponding to the specific physical location based at least in part on the identifier. Two or more people may be concurrently occupying adjacent physical locations and each receiving distinct video-audio streams. Either or both of the video and the audio may be provided as private and substantially only seen or heard by the person occupying the specific location.

Abstract: Image surveillance and reporting technology, in which an event that is indicative of potential physical activity within an area corresponding to a location of a camera unit is detected. In response to detection of the event, the camera unit is controlled to capture one or more images of the area corresponding to the location of the camera unit. The one or more images captured by the camera unit are analyzed to determine whether the one or more images include image data that is indicative of relevant physical activity within the area corresponding to the location of the camera unit. The one or more images are handled based on the determination of whether the one or more images include image data that is indicative of relevant physical activity within the area corresponding to the location of the camera unit.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for object detection using neural networks. In one aspect, one of the methods includes obtaining an input image; processing the input image using an object detection neural network to generate an output sequence that comprises respective token at each of a plurality of time steps, wherein each token is selected from a vocabulary of tokens that comprises (i) a first set of tokens that each represent a respective discrete number from a set of discretized numbers and (ii) a second set of tokens that each represent a respective object category from a set of object categories; and generating, from the tokens in the output sequence, an object detection output for the input image.

Abstract: A system uses a hybrid key-value storage engine that uses log-structured merge tree and a segmented log-structured object store. The system performs garbage collection of stale document versions avoiding index lookup during log segment compaction. The system separates index and document data to minimize write amplification. The system maintains a delete list using a log-structured merge-tree to store stale document sequence numbers and corresponding sizes per log segment. For each log segment from the plurality of log segments, the system determines a measure of fragmentation of the log segment based on sizes of deleted documents of the log segment from the second log-structured merge-tree. If the fragmentation exceeds a threshold, the system initiates a compaction operation for the log segment.

Abstract: A power supply system includes a multitude of independent electrical systems each comprising one or more power blocks, wherein each power block is configured to provide a respective power output and a converter comprising a multitude of inputs coupled to the multitude independent electrical systems and comprising a multitude of outputs coupled to a multitude of independent loads, the converter configured to aggregate the power output of each of the multitude of independent electrical systems and to output direct current (DC) power to the multitude of independent loads through the multitude of outputs based on the aggregated power output. The power supply system includes a power controller coupled to the converter and configured to allocate power to each of the multitude of independent loads based on input power from each of the multitude of independent electrical systems and power consumption from each of the multitude of independent loads.

Abstract: The present disclosure relates to the extraction of lithium from liquid resources such as natural and synthetic brines, leachate solutions from clays and minerals, and recycled products.

Abstract: Disclosed are novel fused mescaline derivative compounds, notably C1-substituted isopropylamine fused heterocyclic mescaline derivatives, including C1-substituted isopropylamine fused dioxolane and fused dioxane mescaline derivatives, and pharmaceutical and recreational drug formulations containing the same. Methods of making and using these compounds are also disclosed.

Abstract: A router node comprises a link discovery module, a security module, a secure access module and storage. The link discovery module discovers a link to an adjacent router node and receives its first loopback address. The link discovery module creates a first tunnel between the security module in the router node and the first loopback address. The security module receives a second loopback address for the second router node, and creates a second tunnel. The security module repeats the discovering, receiving and creating steps for each router node adjacent to the first router node. The storage separately stores a link discovery routing table which comprises information relating to the links between the router node and each adjacent router note; a security routing table which stores the unique first loopback address; and a secure access routing table which stores the unique second loopback address.

Abstract: Red rust staining of Al/Zn coated steel strip in “acid rain” or “polluted” environments can be minimised by forming the coating as an Al—Zn—Si—Mg alloy coating with an OT:SDAS ratio greater than a value of 0.5:1, where OT is the overlay thickness on a surface of the strip and SDAS is the measure of the secondary dendrite arm spacing for the Al-rich alpha phase dendrites in the coating. Red rust staining in “acid rain” or “polluted” environments and corrosion at cut edges in marine environments can be minimised in Al—Zn—Si—Mg alloy coatings on steel strip by selection of the composition (principally Mg and Si) and solidification control (principally by cooling rate) and forming Mg2Si phase particles of a particular morphology in interdendritic channels.

Abstract: Monitoring system alert technology, in which monitoring system data is accessed from a monitoring system that is located in a property of a user and the monitoring system data is analyzed against one or more rules that define alerts provided for the monitoring system. Based on the analysis, a determination is made that an alert for the monitoring system is needed and conditions for providing the alert are accessed. Location of a mobile device of a user associated with the monitoring system and timing related to providing the alert are monitored. The monitored location of the mobile device and the monitored timing are analyzed with respect to the accessed conditions. Based on the analysis, a determination is made that the accessed conditions for providing the alert are met and the alert is output at the mobile device.

Abstract: A medical device hub power management system, method, and apparatus are disclosed. An example hub connectivity station includes a connectivity stage configured to provide a data connection with an external network. The hub connectivity station also includes at least one docking apparatus configured to connect to at least one medical device. The docking apparatuses are connected to the connectivity station in a stacked arrangement. The docking apparatuses and connectivity stage include power and data connectors to enable data and power to be provided through the hub connectivity station. To prevent electrical shock, a top power connector of each docking apparatus is disconnected from power when that docking apparatus is not connected to another docking apparatus or the connectivity stage. Power is provided to the top power connector after detecting another docking apparatus or the connectivity stage is connected to the top of the docking apparatus.

Abstract: A pet locating system and method includes a pet tracking device to be worn by a pet, with the device including a Bluetooth scanner to monitor a status of a presence or an absence of Bluetooth beacons within a predefined area, a Wi-Fi module to connect to a wireless network to communicate the status with a cloud-based server, a cellular modem to communicate the status with the cloud-based server when the device is outside a range of the wireless network, and a GPS receiver to obtain location data of a pet wearing the device and communicate the location data with the cloud-based server.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z?? (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: A head-mounted display system includes a head-mounted display unit a display that, in use, is held in an operational position over a user's face. The head-mounted display system further comprises a flow generator configured to generate a flow of air, and an air guide arrangement coupled to the flow generator to enable the flow generator to direct air to, or draw air from, one or more selected areas in proximity of the head-mounted display system.

Abstract: An atmospheric water generation system comprises water vapor consolidation systems configured to increase the relative humidity of a controlled air stream prior to condensing water from the controlled air stream. The water vapor consolidation system comprises a fluid-desiccant flow system configured to decrease the temperature of the desiccant to encourage water vapor to be absorbed by the desiccant from an atmospheric air flow. The desiccant flow is then heated to encourage water vapor evaporation from the desiccant flow into a controlled air stream that circulates within the system. The humidity of the controlled air stream is thereby increased above the relative humidity of the atmospheric air to facilitate condensation of the water vapor into usable liquid water.

Abstract: An electronic monitoring system is described that receives data from a particular monitoring system, receives data from multiple other monitoring systems, analyzes data received from the particular monitoring system irrespective of data received from the multiple other monitoring systems, based on the analysis, determines whether one or more events occur at the particular environment, and in response to determining that a particular event occurs at the particular environment, evaluates the particular event against a set of rules, selects, based on the evaluation results, a particular subset of the multiple other monitoring systems to serve as a cooperative monitoring network, assesses data received from the particular subset of the multiple other monitoring systems, based on the assessment, tracks, in connection with the particular event, events detected by the particular subset of the multiple other monitoring systems, and handles the particular event based on the tracked events.