Abstract: The present disclosure features methods, cells or cell lines, and compositions for increasing the amount of products, e.g., proteins, produced by a cell or cell line by reducing the level of a non-essential endogenous protein.

Abstract: A user controls a computer application with a first multi-modal agent and a second multi modal agent. A shared context manager is configured to receive from the first agent a first intent having a first data field, and to receive from the second agent a second intent having a second data field. The shared context manager forms a modified second intent based upon the first data field, and provides the modified second intent to the second agent. An intent stack is configured to receive the first intent and the modified second intent from the shared context manager and to store the first intent and the modified second intent.

Abstract: The present disclosure features methods, cells or cell lines, and compositions for increasing the amount of products, e.g., proteins, produced by a cell or cell line by reducing the level of a non-essential endogenous protein.

Abstract: The disclosure relates to an improved brachytherapy device, methods of preparation, and uses thereof. M ore particularly, a flexible bioresorbable brachytherapy device is provided for application on a wound site in a subject. The device includes a sealed radioactive source having opposite first and second sides, wherein the sealed radioactive source includes a radioactive component comprising a plurality of radio-isotope particles dispersed within a carrier. A barrier surrounds the radioactive component providing the sealed radioactive source, wherein the barrier functions as a barrier, when implanted at the wound site, providing the sealed radioactive source for at least six half-lives of the plurality of radio-isotope particles. A bioresorbable shield located on the first side of the sealed radioactive source is configured to shield radioactivity when implanted at the wound site for at least six half-lives of the plurality of radio-isotope particles.

Abstract: The specification relates generally to the post-genomic identification of therapeutic targets and agents. In particular the specification relates to PSMD9 inhibitors and methods for preventing or treating metabolic disorders such as fatty liver disease that are associated with dysregulation of lipid homeostasis.

Abstract: Provided is a chamber configuration for a reverse flow centrifuge, and a reverse flow centrifuge system configured for low fluid volume and small radius rotation. The compact reverse flow centrifuge system has a reusable subsystem and a single use replaceable subsystem. The replaceable subsystem comprises a separation chamber, fluid delivery manifold and rotational mounting connecting the separation chamber to the fluid manifold. The single use replaceable subsystem provides a closed environment for execution of reverse flow centrifugation processes. The separation chamber has a substantially conical fluid enclosure portion connected to a neck portion, and a dip tube extends centrally through the conical fluid enclosure to provide a fluid path to the tip of the conical fluid enclosure.

Abstract: Embodiments provide a fluid recovery system and method for use with concentrator systems for concentrating particles suspended in a fluid and where this suspension is recovered from a fluid stream drawn from the concentrator system. A controller is configured to control valve actuation to direct concentrate being drawn from the concentrator chamber through a recovery tube to a recovery reservoir based on fluid volume movement. The system can use a density sensor to detect density transitions in fluid in the fluid recovery tube to identify leading and trailing edges of a portion of concentrated particles in fluid suspension passing through the recovery tube and actuate recovery valves based on objectives for maximising particle recovery with minimal dilution.

Abstract: Techniques for cooperative document generation include methods, one of the methods includes receiving, from a mobile device, a request to start an insurance claim, the mobile device including an application configured to guide the user through the claim process. The method includes establishing a session between a computer and the mobile device. The method includes displaying images of the user interface of the mobile device. The method includes receiving information concerning the insurance claim from the mobile device, the information provided by the user in response to prompts provided on the mobile device. The method includes displaying the information on the computer. The method includes enabling the customer service representative to alter the information or request additional information be provided. The method includes adding the information to a data record regarding the insurance claim in response to an indication that the customer service representative has verified the information.

Abstract: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.

Abstract: Embodiments provide a liquid handling system arranged for preparation of small volume liquid formulations and dispensing these into output vessels. The system can be utilised for a variety of low volume liquid formulation preparation applications, with cell therapies being one example application.

Abstract: An augmented reality structural assessment system may include a display device, at least one sensor configured to generate image data from a structure, and a processor. The processor may receive the image data that represents one or more portions of the structure and receive motion data representative of a number of steps traversed by a user about the structure. The processor may generate a visualization of a scenario related to structural damage to the one or more portions of the structure of the image data. The visualization may be presented to a user via the display device, such that the visualization augments a view of the structure via the display device to include the one or more dimensions. The processor may then receive input data regarding one or more assessments of damage to the structure corresponding to the scenario, the image data, and the one or more dimensions, and store the data regarding one or more assessments of damage in a storage component.

Abstract: Provided is a chamber configuration for a reverse flow centrifuge, and a reverse flow centrifuge system configured for low fluid volume and small radius rotation. The compact reverse flow centrifuge system has a reusable subsystem and a single use replaceable subsystem. The replaceable subsystem comprises a separation chamber, fluid delivery manifold and rotational mounting connecting the separation chamber to the fluid manifold. The single use replaceable subsystem provides a closed environment for execution of reverse flow centrifugation processes. The separation chamber has a substantially conical fluid enclosure portion connected to a neck portion, and a dip tube extends centrally through the conical fluid enclosure to provide a fluid path to the tip of the conical fluid enclosure.

Abstract: A system may include a database that has a number of datasets regarding a number of commercial items. The system may also include a processor that may communicative couple to a mobile electronic device. The processor may receive an image of a commercial item from the mobile electronic device, determine an identity of the commercial item based on the image and the number of datasets in the database, and determine one or more information links relevant to the commercial item based on the identity. The one or more information links may display information regarding the commercial item. The processor may then send the one or more information links to a mobile electronic device. The mobile electronic device may then display the one or more information links with the image.

Abstract: A cell culture media comprising an effective amount of 3-Thiopheneacetic acid (3TAA).

Abstract: An augmented reality structural assessment system may include a display device, at least one sensor configured to generate image data from a structure, and a processor. The processor may receive the image data that represents one or more portions of the structure and receive motion data representative of a number of steps traversed by a user about the structure. The processor may generate a visualization of a scenario related to structural damage to the one or more portions of the structure of the image data. The visualization may be presented to a user via the display device, such that the visualization augments a view of the structure via the display device to include the one or more dimensions. The processor may then receive input data regarding one or more assessments of damage to the structure corresponding to the scenario, the image data, and the one or more dimensions, and store the data regarding one or more assessments of damage in a storage component.

Abstract: Techniques for cooperative document generation include methods, one of the methods includes receiving, from a mobile device, a request to start an insurance claim, the mobile device including an application configured to guide the user through the claim process. The method includes establishing a session between a computer and the mobile device. The method includes displaying images of the user interface of the mobile device. The method includes receiving information concerning the insurance claim from the mobile device, the information provided by the user in response to prompts provided on the mobile device. The method includes displaying the information on the computer. The method includes enabling the customer service representative to alter the information or request additional information be provided. The method includes adding the information to a data record regarding the insurance claim in response to an indication that the customer service representative has verified the information.

Abstract: Disclosed is an oligomer or polymer obtained by reacting at least one monomeric, oligomeric or polymeric isocyanate having two or more isocyanate groups with 2-hydroxy-3-butenoic acid and/or at least one alkyl ester of 2-hydroxy-3-butenoic acid. A composition comprising a said oligomer or polymer is also disclosed.

Abstract: A system may include a database that has a number of datasets regarding a number of commercial items. The system may also include a processor that may communicative couple to a mobile electronic device. The processor may receive an image of a commercial item from the mobile electronic device, determine an identity of the commercial item based on the image and the number of datasets in the database, and determine one or more information links relevant to the commercial item based on the identity. The one or more information links may display information regarding the commercial item. The processor may then send the one or more information links to a mobile electronic device. The mobile electronic device may then display the one or more information links with the image.

Abstract: Techniques for cooperative document generation include methods, one of the methods includes receiving, from a mobile device, a request to start an insurance claim, the mobile device including an application configured to guide the user through the claim process. The method includes establishing a session between a computer and the mobile device. The method includes displaying images of the user interface of the mobile device. The method includes receiving information concerning the insurance claim from the mobile device, the information provided by the user in response to prompts provided on the mobile device. The method includes displaying the information on the computer. The method includes enabling the customer service representative to alter the information or request additional information be provided. The method includes adding the information to a data record regarding the insurance claim in response to an indication that the customer service representative has verified the information.

Abstract: An augmented reality structural assessment system may include a display device, at least one sensor configured to generate image data from a structure, and a processor. The processor may receive the image data that represents one or more portions of the structure and receive motion data representative of a number of steps traversed by a user about the structure. The processor may generate a visualization of a scenario related to based on a scenario related to structural damage to the one to the one or more portions of the structure of the image data. The visualization may be presented to a user via the display device, such that the visualization augments a view of the structure via the display device to include the one or more dimensions. The processor may then receive input data regarding one or more assessments of damage to the structure corresponding to the scenario, the image data, and the one or more dimensions, and store the data regarding one or more assessments of damage in a storage component.