Abstract: The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.

Abstract: The present invention provides methods for the prevention, treatment and/or amelioration of fibrosis or fibrotic conditions. The present invention further provides small molecule inhibitors of Wnt- and TGF-p-mediated ?-catenin signaling to prevent, treat and/or ameliorate fibrosis or fibrotic conditions. Kits comprising small molecule inhibitors of Wnt- and TGF-p-mediated ?-catenin signaling and methods of identifying small molecule inhibitors of Wnt- and TGF-p-mediated ?-catenin signaling are also provided.

Abstract: An imaging system is provided with an ultrasound catheter and a controller coupled to the ultrasound catheter. The catheter includes a localizer sensor configured to generate positional information for the ultrasound catheter, and an imaging ultrasound sensor having a restricted field of view. The controller co-registers images from the imaging ultrasound sensor with positional information from the localizer sensor.

Abstract: The present invention provides an apparatus (100) for forming circumferential grooves (14) in the exterior surface of a linear member (10), such as a tube. The grooves are formed by rotating a cylindrical cutting element (120) around the tube such that cutting means in the cylindrical cutting element form the grooves. One rotation of the cylindrical cutting element causes multiple grooves to be formed in the surface of the tubes.

Abstract: The present invention relates to an optical fiber connector, and in particular to a Subscriber Connector (SC)-type push/pull optical fiber connector and to a method of forming and using such a connector. The SC-type optical fiber connector (101) is made up of an optical fiber (8), a cylindrical ferrule (14), a ferrule holder (16), a spring biasing means (17), a ferrule holder carrier (50), an inner housing (120), and an outer housing (40). The optical fiber (8) is held within the ferrule (14) and the ferrule (14) is held by the ferrule holder (16). The ferrule holder (16) is engaged within a receiving portion (54) of the ferrule holder carrier (50), said holder and carrier being relatively moveable with respect to each other along the ferrule axis (5) between limits defined by an interaction between the ferrule carrier (50) and the ferrule holder (16).

Abstract: An imaging system is provided with an ultrasound catheter and a controller coupled to the ultrasound catheter. The catheter includes a localizer sensor configured to generate positional information for the ultrasound catheter, and an imaging ultrasound sensor having a restricted field of view. The controller co-registers images from the imaging ultrasound sensor with positional information from the localizer sensor.

Abstract: The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding do mains for two different binding sites of LRP6 and compositions and methods of use thereof.

Abstract: The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.

Abstract: The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL-4 and as diagnostics.

Abstract: A system for remotely controlling the positioning within the body of a patient of an elongated medical device optionally having a control handle, comprises a catheter position system and a remote controller configured to control the robotic device. The catheter position system includes a handle controller; a sled member coupled to the handle controller, the sled member being configured to position the medical device within the body of the patient; and a sled base configured to advance the sled member towards the body of a patient, the sled bed being coupled to a sterile barrier effective to maintain sterility inside the sled base. The catheter position system may include a control system configured to issue positioning commands in response to sensor signals received from the catheter. The catheter position system may also include a motor driven rotatable catheter introducer clamp configured to enable rotation of an introducer.

Abstract: A guidance system may include an optical system to focus incident radiation onto a detector configured to generate at least one guidance signal in response to the focused incident radiation. The optical system may include a first lens having a first side and a second side, the first side consisting of a Fresnel lens formed on a generally convex surface and the second side being generally planar.

Abstract: The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.

Abstract: The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL4 and as diagnostics.

Abstract: A system for remotely controlling the positioning within the body of a patient of an elongated medical device optionally having a control handle, comprises a robotic system and a remote controller configured to control the robotic device. The robotic system comprises a handle controller; a sled member coupled to the handle controller, the sled member being configured to position the medical device within the body of the patient; and a sled base configured to advance the sled member towards the body of a patient, the sled bed being coupled to a sterile barrier effective to maintain sterility inside the sled base. A medical device introducer is effective to guide the elongated medical device into a patient's body.

Abstract: The present invention provides an optical fibre connector (1) having a fibre connector sub-assembly (21) and an outer connection sleeve (40), sub-assembly (21) having an optical fibre and an inner housing (20). The optical fibre is held within housing (20) along axis (5), and is terminated for optical connection to a mating connector along a connection direction (61). Sleeve (40) has a securing portion (50) and a connecting portion (48). Securing portion (50) is fixed to sub-assembly (21) so that sleeve (40) extends around sub-assembly (21). Connecting portion (48) has an inner surface that provides a socket (44) for receiving a corresponding portion of a mating connector along direction (61). Socket (44)'s inner surface has at least one rib that extends transverse to direction (61), connecting portion (48) being elastic such that the rib(s) may, in use, stretch over and engage with a corresponding feature of a mating connector.

Abstract: A method of operating a lighting fixture comprising a plurality of discrete illumination sources of distinguishably different color coordinates comprises determining target color coordinates and luminous flux at which to operate the lighting fixture, determining input electrical power values for each of the plurality of discrete illumination sources that substantially produce the target color coordinates and luminous flux by referencing a calibration data lookup table having calibration data based on measurements of the plurality of discrete illumination sources, determining a color mixing zone defined by three distinguishably different color coordinates of the plurality of discrete illumination sources within which the target color coordinates lie according to the calibration data, determining luminous flux ratios for each of the plurality of discrete illumination sources having one of the three distinguishably different color coordinates defining the color mixing zone that substantially produces the target

Abstract: An integrated electrophysiology and ultrasound imaging system includes a workstation, electrophysiology processing circuits, a compact ultrasound imaging system having a combination of an isolation circuit, an ultrasound signal generator, and a beam former within a single unit. The integrated workstation provides a single control interface and data display for the electrophysiology and ultrasound imaging subsystems. Integrating the control of electrophysiology and ultrasound imaging equipment within a single workstation reduces clinician workload.

Abstract: A caterpillar traction apparatus (110), wherein two pairs of pulleys (122 & 123, 132 & 133) can be driven at different speeds, so that the linear member (40) being driven by the mechanism is subjected to either compression or extension forces.