Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: A hearing assistance system is disclosed that comprises a hearing assistance device configured to reproduce sounds and to assist a person to hear the sounds, the hearing assistance device including a left hearing assistance device and a right hearing assistance device, and a computing device in communication with the hearing assistance device. The computing device interacts with the hearing assistance device to implement a fitting mode wherein the hearing assistance device is caused to generate fitting sounds usable to evaluate whether the left and right hearing devices are properly fitted into respective left and right ears of the person. The computing device produces a communication indicative of whether the left and right hearing assistance devices are properly fitted into respective left and right ears of the person.

Abstract: The present disclosure provides a chassis configured for use an energy storage system. The chassis comprises a housing configured to support a plurality of battery cells, a first sidewall pad and a top wall pad configured to cushion the plurality of battery cells when supported within the housing, a compression wedge configured to fit between the plurality of battery cells and a second sidewall of the chassis to apply a compressive load on the plurality of battery cells, and a retention bracket configured to connect to a first sidewall of the chassis and the second sidewall to maintain the plurality of battery cells against a rear wall of the chassis.

Abstract: Fabricating a capacitor includes forming conduits in a porous layer of material. The porous layer of material has particles that each includes a dielectric on a core. The formation of the conduits causes a portion of the dielectric to convert from a first phase to a second phase. The method also includes removing at least a portion of the second phase of the dielectric from the porous layer of material.

Abstract: The disclosed technology generally relates dielectric materials and methods of forming the same, and more particularly to a combination of co-fireable dielectric materials that can be attached to each other without the use of adhesives. In an aspect, a composite article comprises a magnetic portion comprising a nickel zinc ferrite. The composite article additionally comprises a non-magnetic portion contacting the magnetic portion, the non-magnetic portion comprising a spinel-structured oxide comprising Mg2-xAl2xTi1-xO4 and having a dielectric constant between about 7 and 14, wherein 0<x?1.

Abstract: Disclosed herein are embodiments of low temperature co-fireable barium tungstate materials which can be used in combination with high dielectric materials, such as nickel zinc ferrite, to form composite structures, in particular for isolators and circulators for radiofrequency components. Embodiments of the material can include flux, such as bismuth vanadate, to reduce co-firing temperatures.

Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

Abstract: In some embodiments, a method for processing an optical fiber includes: drawing an optical fiber through a draw furnace, conveying the optical fiber through a flame reheating device downstream from the draw furnace, wherein the flame reheating device comprises one or more burners each comprising: a body having a top surface and an opposing bottom surface, an opening within the body extending from the top surface through the body to the bottom surface, wherein the optical fiber passes through the opening, and one or more gas outlets within the body; and igniting a flammable gas provided by the one or more gas outlets to form a flame encircling the optical fiber passing through the opening, wherein the flame heats the optical fiber by at least 100 degrees Celsius at a heating rate exceeding 10,000 degrees Celsius/second.

Abstract: Systems and methods for determining the location of a vehicle are disclosed. In one embodiment, a method for localizing a vehicle includes driving over a first road segment, identifying by a first localization system a set of candidate road segments, obtaining vertical motion data while driving over the first road segment, comparing the obtained vertical motion data to reference vertical motion data associated with at least one candidate road segment, and identifying, based on the comparison, a location of the vehicle. The use of such localization methods and systems in coordination with various advanced vehicle systems such as, for example, active suspension systems or autonomous driving features, is contemplated.

Abstract: An anti-fouling composition, and uses thereof in the industrial preparation of ethylenically unsaturated monomers comprising at least one heteroatom, such as acrylic monomers are disclosed.

Abstract: An alkaline electrolyte membrane (AEM) electrolytic device is designed, assembled and evaluated for water electrolysis, composed of an anode for oxygen generation, a cathode for hydrogen generation, an AEM for anion conductive, and two internal water gas separators (IWGSs) for water supplying to the anode and the cathode, respectively, as well as for automatically separation of water and gas produced from the anode or from the cathode. There is no need of pumps for water and gas circulations and no external water gas separators (EWGSs) that are used by conventional water electrolyzers. The corrosive electrolyte is confined in the water containers and will not damage other parts in the electrolytic device. Furthermore, novel multi gas diffusion layers are used to replace the conventional single gas diffusion layer. The pore size is configurable to improve the mass transfer of electrochemical reactions and promote electrochemical reactions.

Abstract: Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.

Abstract: A virtual mailbox is established for a first user based on a virtual mailbox definition specified by the first user. A message directed to the first user is received from a first device associated with a second user. A location within a real-world environment of the first user corresponding to the virtual mailbox is identified. A marker associated with the virtual mailbox is detected within the real-world environment of the first user. Based on detecting the marker, the second device presents the message overlaid on the real-world environment at the location corresponding to the virtual mailbox.

Abstract: A method of forming a composite material for use as an isolator or circulator in a radiofrequency device comprises providing a low temperature fireable outer material, the low fireable outer material having a garnet or scheelite structure, inserting a high dielectric constant inner material having a dielectric constant above 30 within an aperture in the low temperature fireable outer material, and co-firing the lower temperature fireable outer material and the high dielectric constant inner material together at temperature between 650-900° C. to shrink the low temperature fireable outer material around an outer surface of the high dielectric constant inner material to form an integrated magnetic/dielectric assembly without the use of adhesive or glue.

Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

Abstract: Provided is a lubricating oil composition that includes a major amount of a lubricant base oil and a minor amount of a viscosity index improver comprising a syndiotactic propylene-based ethylene-propylene copolymer comprising: a) 2 to 20% by weight of ethylene, b) 80 to 98% by weight of propylene; c) 50 to 99% of rr triads; and d) Mw (LS) of 10 to 250 kg/mol.

Abstract: A method includes moving a stabilization device comprising a stabilization surface relative to a base of a surgical cart, wherein the moving comprises moving the stabilization device from a retracted position in which the stabilization surface is spaced from the ground surface to a deployed position in which the stabilization surface is in contact with the ground surface, and wherein the moving comprises overcoming a biasing force biasing the stabilization device toward the retracted position.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Methods and apparatus relating to scalable access control checking for cross-address-space data movement are described. In an embodiment, a memory stores an InterDomain Permissions Table (IDPT) having a plurality of entries. At least one entry of the IDPT provides a relationship between a target address space identifier and a plurality of requester address space identifiers. A hardware accelerator device allows access to a target address space, corresponding to the target address space identifier, by one or more of requesters, corresponding to the plurality of requester address space identifiers, respectively, based at least in part on the relationship provided by the at least one entry of the IDPT. Other embodiments are also disclosed and claimed.

Abstract: Embodiments of an iron-based coating configured to be thermally sprayed are disclosed. The iron-based coatings can be fully readable, thus allowing for thickness measurements to be performed on the coating with standard magnetic measuring equipment. Further, the iron-based coating can have advantageous properties, such as high hardness, high wear resistance, and high adhesion strength.