Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds: the use of such compounds in medicine; and methods of treating patients with such compounds: wherein A, W, V, Z, U, X, Y and B are as defined herein.

Abstract: The invention relates to a method of making a contact lens, the method comprising identifying the eccentricity of a lens produced in a mold half, lathing the lens and adjusting the path of the lathe to take account of the eccentricity, and a computer program for controlling the lathe.

Abstract: The invention relates to a method of making a contact lens, the method comprising identifying the eccentricity of a lens produced in a mould half, lathing the lens and adjusting the path of the lathe to take account of the eccentricity, and a computer programme for controlling the lathe.

Abstract: A mould for the production of a contact lens, the mould comprising a first mould half shaped to provide the front surface of the contact lens; and a second mould half shaped to provide the rear surface of the contact lens, wherein the first and second mould halves form a mould cavity, wherein the first mould half has a first rim and the second mould half has a second rim, and the first and second rims fit together to provide a seal for the mould cavity, wherein the first rim is inclined at an angle of x relative to an axis passing through the centre of the first and second mould halves, wherein x is from 30 to 60°, and wherein the second rim is inclined at an angle of x-y relative to the axis passing through the centre of the first and second mould halves, where y is from 0 to 4°, and wherein the first and second rims provide a guide for the mould halves, a method of making a contact lens using the mould and a method of making a mould.

Abstract: A system and associated method for synchronizing a record with a web document. A synchronizer selects a web document that is stored in a published web document repository of a content management system. The oldest web document since the latest update is selected and checked for availability. The synchronizer locates a record that corresponds to the selected web document. The synchronizer then checks respective version of the web document and the record to determine whether the record correctly represents the web document. The synchronizer then verifies whether the selected web document is available to users to avoid synchronizing latent web document that is not available to users. The synchronizer updates the located record.

Abstract: This invention relates to peptides useful for releasing active agent in the fields of diagnostics and drug delivery.

Abstract: A system and associated method for synchronizing a record with a web document. A synchronizer selects a web document that is stored in a published web document repository of a content management system. The oldest web document since the latest update is selected and checked for availability. The synchronizer locates a record that corresponds to the selected web document. The synchronizer then checks respective version of the web document and the record to determine whether the record correctly represents the web document. The synchronizer then verifies whether the selected web document is available to users to avoid synchronizing latent web document that is not available to users. The synchronizer updates the located record.

Abstract: A navigation manager component cooperable with a user interface renderer is described. The navigation manager manages one or more navigation units and maintains a navigation unit cursor. Each navigation unit is associated with another navigation unit managed by the same navigation manager. The navigation manager provides a range of navigation services, which operate upon the navigation unit cursor. These services include a service to navigate forwards and a service to navigate backwards. These services take into account the associations between navigation units in order to determine the correct sequence of navigation units for forwards and backwards navigation. The services also determine whether the items represented by each navigation unit include eligible items or items for which data entry is incomplete. In this way, navigation units for which all the items represented by the navigation unit are ineligible can be passed over by the navigation services, to that they never become current.

Abstract: This invention relates to peptides useful for releasing active agent in the fields of diagnostics and drug delivery.

Abstract: Systems, methods and computer program products are provided for building and displaying dynamic graphical user interfaces (GUIs) that can be updated automatically without requiring code-level modification and recompiling. In response to a request to display a particular GUI on a computer display, an Extensible Markup Language (XML) data group is selected from a plurality of XML data groups and an XML display layout is selected from a plurality of XML display layouts. The selected XML data group includes one or more aggregations of data hierarchically ordered within the selected XML data group. XML data items are hierarchically ordered within each of the aggregations of data. The selected XML display layout contains one or more areas that define respective GUI display spaces within which XML data items from the respective aggregations of data can be displayed.

Abstract: A user interface component, gauge, is adapted to present a changing value according to a pre-determined behavioral and presentational characteristic. The component includes a kernel which is adapted to display a presentation value; a control interface through which an external system communicates the changing value to the kernel; a presentation interface through which the presentation characteristic of the user interface component is determined; and a behavior interface through which an external system communicates with said kernel to determine the behavioral characteristic of the user interface component.