Patents by Inventor David John Holmes

David John Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptidyl t-RNA hydrolase (PTH)
    Patent number: 7202071
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: April 10, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • Novel pth
    Publication number: 20030232373
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 14, 2003
    Publication date: December 18, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • Map
    Publication number: 20030082614
    Abstract: The invention provides map polypeptides and polynucleotides encoding map polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing map polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: September 26, 2002
    Publication date: May 1, 2003
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin K. R. Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B. Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • ndp
    Publication number: 20030017532
    Abstract: The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: July 27, 2001
    Publication date: January 23, 2003
    Inventors: SanJoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B. Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • Map
    Publication number: 20020150963
    Abstract: The invention provides map polypeptides and polynucleotides encoding map polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing map polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 29, 2001
    Publication date: October 17, 2002
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin K.R. Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B. Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • Phosphatidylglycerophosphate synthase from Staphylococcus aureus
    Patent number: 6458572
    Abstract: The invention provides Phosphatidylglycerophosphate Synthase polypeptides from Staphylococcus aureus (“pgsA polypeptides”). Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Holmes, Chanal Myriam Petit, Christopher Michael Traini, Richard Lloyd Warren
  • murF2
    Publication number: 20020127596
    Abstract: The invention provides murF2 polypeptides and polynucleotides encoding murF2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murF2 polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: December 13, 2000
    Publication date: September 12, 2002
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin K. R. Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas Berthold Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • PgsA
    Patent number: 6448037
    Abstract: The invention provides pgsA polypeptides and polynucleotides encoding pgsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Holmes, Chantal Myriam Petit, Christopher Michael Traini, Richard Lloyd Warren
  • metK
    Publication number: 20020102700
    Abstract: The invention provides metK polypeptides and polynucleotides encoding metK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metK polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 14, 2001
    Publication date: August 1, 2002
    Inventors: Sanjoy Biswas, Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Richard Lloyd Warren, Magdalena Zalacain, Stephanie Van Horn
  • nusB
    Publication number: 20020091237
    Abstract: The invention provides nusB polypeptides and polynucleotides encoding nusB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nusB polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 24, 2001
    Publication date: July 11, 2002
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Richard Lloyd Warren, Magdalena Zalacain
  • inFB
    Patent number: 6399343
    Abstract: The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 4, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, Richard Lloyd Warren, Magdalena Zalacain, Chi Young So, Christopher M Traini, David John Holmes, Karen Anne Ingraham, Thomas B Mathie
  • Novel pth
    Publication number: 20020058799
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 2, 2001
    Publication date: May 16, 2002
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • trmD
    Patent number: 6350600
    Abstract: The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corp.
    Inventors: Sanjoy Biswas, James Raymond Brown, Chi Young So, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • Nucleic acids encoding Streptococcus pneumoniae FabG
    Patent number: 6346395
    Abstract: The invention provides FabG polypeptides and polynucleotides encoding FabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 27, 1999
    Date of Patent: February 12, 2002
    Assignee: SmithKline Beecham Corp.
    Inventors: Alison Francis Chalker, Christine Debouck, David John Holmes, Karen Anne Ingraham, Deborah Dee Jaworski, Anna Lisa Kosmatka, Damien McDevitt, Jeffrey Mooney, Stewart C Pearson, Chi Yong So, Nicola Gail Wallis, Min Wang, Richard Lloyd Warren, Yi Yi Zhong
  • yhxB
    Patent number: 6340564
    Abstract: The invention provides yhxB polypeptides and polynucleotides encoding yhxB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yhxB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: January 22, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen Anne Ingraham, Chi Yong So, Stephanie Van Horn, Alison Francis Chalker, David John Holmes, Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Patrick Vernon Warren, Richard Lloyd Warren, Magdalena Zalacain
  • ytgP
    Patent number: 6326172
    Abstract: The invention provides ytgP polypeptides and polynucleotides encoding ytgP polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ytgP polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: December 4, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Sanjoy Biswas, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Patrick Vernon Warren, Stephanie Van Horn, Magdalena Zalacain
  • Pth
    Patent number: 6303771
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: October 16, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • Response regulator
    Patent number: 6294652
    Abstract: The invention provides Response regulator polypeptides and polynucleotides encoding Response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: September 25, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Yigong Ge, David John Holmes, Karen A Ingraham, John Throup, Nicola Gail Wallis, Magdalena Zalacain
  • yfjO
    Publication number: 20010023064
    Abstract: The invention provides yfjO polypeptides and polynucleotides encoding yfjO polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yfjO polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: December 13, 2000
    Publication date: September 20, 2001
    Inventors: Sanjoy Biswas, Alexander Bryant, James Raymond Brown, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Stephanie Van Horn, Richard Lloyd Warren, Magdalena Zalacain
  • Isolated nucleic acid encoding nucleotide pyrophosphorylase
    Patent number: 6268177
    Abstract: The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: July 31, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain