Patents by Inventor David John Miller
David John Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200207780Abstract: The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.Type: ApplicationFiled: May 24, 2017Publication date: July 2, 2020Inventors: Luke O'Neill, Rebecca Coll, Matthew Cooper, Avril Robertson, Kate Schroder, Angus Murray MacLeod, David John Miller
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Patent number: 9839771Abstract: Apparatus and methods are provided for accessing body lumens and/or for delivering instruments into body lumens, e.g., vessels within a patient's vasculature. A flexible sheath is provided that is expandable from a contracted condition to an enlarged condition wherein the sheath at least partially defines a lumen therein. The sheath is lubricious and has a relatively thin wall, thereby providing a collapsible/expandable guide for delivering fluids and/or instruments through tortuous anatomy and/or into relatively narrow passages. The sheath is advanced from an entry site to a body lumen in the contracted condition. Once the sheath reaches a target body lumen, the sheath is expanded to the enlarged condition, thereby defining a lumen within the sheath, and fluids and/or instruments are introduced into the body lumen via the sheath lumen. Upon completing the procedure, the sheath is removed from the body lumen.Type: GrantFiled: March 18, 2009Date of Patent: December 12, 2017Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Christian Scott Eversull, Nicholas J. Mourlas, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Patent number: 8439824Abstract: Apparatus and methods for locating morphological features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.Type: GrantFiled: August 15, 2011Date of Patent: May 14, 2013Assignee: The Board of Directors of the Leland Stanford, Jr. UniversityInventors: Nicholas J. Mourlas, Christian Scott Eversull, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Publication number: 20110301417Abstract: Apparatus and methods for locating morphological features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.Type: ApplicationFiled: August 15, 2011Publication date: December 8, 2011Applicant: The Board Of Trustees of the Leland Stanford Jr. UniversityInventors: Nicholas J. Mourlas, Christian Scott Eversull, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Patent number: 8016748Abstract: Apparatus and methods for locating morphological features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.Type: GrantFiled: November 8, 2005Date of Patent: September 13, 2011Assignee: The Board of Trustees of the Leland Stanford Jr. UniversityInventors: Nicholas J. Mourlas, Christian Scott Eversull, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Publication number: 20110034790Abstract: Apparatus and methods for locating morphological features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.Type: ApplicationFiled: October 18, 2010Publication date: February 10, 2011Applicant: The Board of Trustees of the Leland Stanford Jr. UniversityInventors: Nicholas J. Mourlas, Christian Scott Eversull, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Patent number: 7762995Abstract: Apparatus and methods are provided for accessing body lumens and/or for delivering instruments into body lumens, e.g., vessels within a patient's vasculature. A flexible sheath is provided that is expandable from a contracted condition to an enlarged condition wherein the sheath at least partially defines a lumen therein. The sheath is lubricious and has a relatively thin wall, thereby providing a collapsible/expandable guide for delivering fluids and/or instruments through tortuous anatomy and/or into relatively narrow passages. The sheath is advanced from an entry site to a body lumen in the contracted condition. Once the sheath reaches a target body lumen, the sheath is expanded to the enlarged condition, thereby defining a lumen within the sheath, and fluids and/or instruments are introduced into the body lumen via the sheath lumen. Upon completing the procedure, the sheath is removed from the body lumen.Type: GrantFiled: April 24, 2003Date of Patent: July 27, 2010Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Christian Scott Eversull, Nicholas J. Mourlas, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Publication number: 20090291915Abstract: A compound of any of formulae (I) to (III) wherein at least one of Y and Z includes a Si atom, is of utility in therapy.Type: ApplicationFiled: December 16, 2001Publication date: November 26, 2009Inventors: Graham Andrew Showell, David John Miller
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Publication number: 20090209522Abstract: A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy, —CN, —C(Rc)2OH, —N(Rd)C(?X)Rc, —C(?X)N(Rc)(Rd), —S(O)m—Rc, —N(Rc)(Rd)S(O)2, —S(O)2N(Rc)(Rd), —N(Rc)2, aryl optionally substituted with Ra or —O-aryl optionally substituted with Ra; or B is present and is —(CH2)n—, —C(Rb)2— or —O—, or B taken together with A or Z can be —C?C(Rb)—, —C(Rb)?C—, —CH2—CH(Rb)— or —CH(Rb)—CH2—; D is —O— or —S(O)m?—; E is a bond or is —(CH2)n—, —N(Rd)—, —(CH2)nN(Rd)— or —N(Rd)(CH2)n—; F is —C(?X)—; G is —(CH2)n—, —N(Rd)—, —(CH2)nN(Rd)— or —N(Rd)(CH2)n; J is a bond, —O—, —N(RC)C(?X)—, —C(?X)N(Rc)—, —S(O)m?—, —N(Rc)S(O)m—, —S(O)nN(Rc)—, —N(Rc)— or —N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.Type: ApplicationFiled: June 27, 2006Publication date: August 20, 2009Inventors: Graham Andrew Showell, David John Miller, Angela Glen, Maria Angeles Cubillo De Dios, Kevin Merchant, Ajay Kumar Mandal
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Publication number: 20090182278Abstract: Apparatus and methods are provided for accessing body lumens and/or for delivering instruments into body lumens, e.g., vessels within a patient's vasculature. A flexible sheath is provided that is expandable from a contracted condition to an enlarged condition wherein the sheath at least partially defines a lumen therein. The sheath is lubricious and has a relatively thin wall, thereby providing a collapsible/expandable guide for delivering fluids and/or instruments through tortuous anatomy and/or into relatively narrow passages. The sheath is advanced from an entry site to a body lumen in the contracted condition. Once the sheath reaches a target body lumen, the sheath is expanded to the enlarged condition, thereby defining a lumen within the sheath, and fluids and/or instruments are introduced into the body lumen via the sheath lumen. Upon completing the procedure, the sheath is removed from the body lumen.Type: ApplicationFiled: March 18, 2009Publication date: July 16, 2009Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Christian Scott Eversull, Nicholas J. Mourlas, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Patent number: 7507824Abstract: The present invention relates to spiro[2H-1-benzopyran-2,4?-piperidine] derivatives having general formula (I), or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these spiro[2H-1-benzopyran-2,4?-piperidine] derivatives in therapy, more specifically for the treatment of CNS disorders.Type: GrantFiled: August 8, 2003Date of Patent: March 24, 2009Assignee: N.V. OrganonInventors: Samuel George Gibson, David John Miller
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Publication number: 20080261918Abstract: A compound of any of formulas (I) to (V): wherein at least one of Y and Z includes a Si atom, is of utility in therapy.Type: ApplicationFiled: December 16, 2003Publication date: October 23, 2008Inventors: Graham Andrew Showell, Louise Marie Walsh, Ajay Kumar Mandal, David John Miller
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Patent number: 7407649Abstract: A compound of formula (I) or formula (II) wherein the variables are as defined in the claimsType: GrantFiled: June 18, 2004Date of Patent: August 5, 2008Assignee: Paradigm Therapeutics LtdInventors: David John Miller, Parminder Kaur Ruprah, Graham Andrew Showell, Louise Marie Walsh
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Patent number: 6979290Abstract: An apparatus for locating morphological features within a body cavity includes a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendabe through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.Type: GrantFiled: May 29, 2003Date of Patent: December 27, 2005Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Nicholas J. Mourlas, Christian Scott Eversull, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Publication number: 20040097788Abstract: An apparatus for locating morphological features within a body cavity includes a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendabe through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.Type: ApplicationFiled: May 29, 2003Publication date: May 20, 2004Inventors: Nicholas J. Mourlas, Christian Scott Eversull, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Publication number: 20040029904Abstract: 1Type: ApplicationFiled: August 8, 2003Publication date: February 12, 2004Inventors: Samuel George Gibson, David John Miller
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Publication number: 20030233115Abstract: Apparatus and methods are provided for accessing body lumens and/or for delivering instruments into body lumens, e.g., vessels within a patient's vasculature. A flexible sheath is provided that is expandable from a contracted condition to an enlarged condition wherein the sheath at least partially defines a lumen therein. The sheath is lubricious and has a relatively thin wall, thereby providing a collapsible/expandable guide for delivering fluids and/or instruments through tortuous anatomy and/or into relatively narrow passages. The sheath is advanced from an entry site to a body lumen in the contracted condition. Once the sheath reaches a target body lumen, the sheath is expanded to the enlarged condition, thereby defining a lumen within the sheath, and fluids and/or instruments are introduced into the body lumen via the sheath lumen. Upon completing the procedure, the sheath is removed from the body lumen.Type: ApplicationFiled: April 24, 2003Publication date: December 18, 2003Inventors: Christian Scott Eversull, Nicholas J. Mourlas, Stephen Arie Leeflang, Asha Shrinivas Nayak, David John Miller
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Patent number: 6645973Abstract: The present invention relates to spiro[2H-1-benzopyran-2,4′-piperidine] derivatives having general formula (I), wherein the substituents R1, R2, X and Y are ase defined in the claims or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these spiro[2H-1-benzopyran-2,4′-piperidine] derivatives in therapy, more specifically for the treatment of CNS disorders.Type: GrantFiled: May 17, 2002Date of Patent: November 11, 2003Assignee: Akzo NobelInventors: Samuel George Gibson, David John Miller