Abstract: Increasing the pressure of a slurry by a filter press in which mineral oxide reacts with carbon dioxide enhances the formation of the carbonate by increasing the solubility and availability of carbon dioxide, accelerating reaction rates, shifting equilibria favorably, and promoting the formation of reaction intermediates like bicarbonate ions. A more efficient and faster synthesis of metal carbonates results.

Abstract: Nodulisporic acids (NAs) comprise a group of indole diterpenes known for their potent insecticidal activities; however, biosynthesis of NAs by its natural producer, Hypoxylon pulicicidum (Nodulisporium sp.) is exceptionally difficult to achieve. The identification of genes responsible for NA production could enable biosynthetic pathway optimization to provide access to NAs for commercial applications. Obtaining useful quantities of NAs using published fermentations methods is challenging, making gene knockout studies an undesirable method to confirm gene function. Alternatively, heterologous gene expression of H. pulicicidum genes in a more robust host species like Penicillium paxilli provides a way to rapidly identify the function of genes that play a role in NA biosynthesis. In this work, we identified the function of four secondary-metabolic genes necessary for the biosynthesis of nodulisporic acid F (NAF) and reconstituted these genes in the genome of P.

Abstract: A system for producing hydrocarbons from a subsea wellbore includes a primary conductor extending into the seabed. In addition, the system includes a wellhead disposed at an upper end of the primary conductor. Further, the system includes a multi bore tubing hanger seated in the wellhead. Still further, the system includes a production tree mounted to the wellhead. The production tree includes a spool body and a production spool extending radially from the spool body. The production spool has an end comprising a connector. Moreover, the system includes a rotatable production guide base coupled to the primary conductor and configured to rotate about the wellhead. The production guide base includes a rigid alignment spool. The alignment spool has a first end releasably coupled to the production spool, a second end comprising a second connector, and non-linear deviation positioned between the first end and the second end.

Abstract: N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefore are prepared by new synthetic methods.

Abstract: N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefore are prepared by new synthetic methods.

Abstract: Salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide are prepared by various methods.

Abstract: N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefor are prepared by new synthetic methods.

Abstract: Salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide are prepared by various methods.

Abstract: The present invention relates to salts of organic acid, in particular salt of nateglinide, combined preparations comprising one or more salts of nateglinide and, optionally, one or more additional ingredients and the use thereof in pharmaceutical compositions for preventing or treating diabetes, cardiovascular disease, or conditions associated therewith.

Abstract: The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors.