Patents by Inventor David John Tweardy

David John Tweardy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STAT3 INHIBITORS
    Publication number: 20240058284
    Abstract: Compounds as STAT3 inhibitors are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing conditions such as cancer, chronic inflammation, and fibrosis using the same, are described.
    Type: Application
    Filed: October 5, 2023
    Publication date: February 22, 2024
    Inventors: Sofia de Achaval, David John Tweardy
  • STAT3 inhibitors
    Patent number: 11826315
    Abstract: Compounds as STAT3 inhibitors are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing conditions such as cancer, chronic inflammation, and fibrosis using the same, are described.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: November 28, 2023
    Assignees: Tvardi Therapeutics, Baylor College of Medicine
    Inventors: Sofia De Achaval, David John Tweardy
  • NOVEL STAT3 INHIBITORS IDENTIFIED BY STRUCTURE-BASED VIRTUAL SCREENING INCORPORATING SH2 DOMAIN FLEXIBILITY
    Publication number: 20220168322
    Abstract: In one aspect, the present disclosure provides methods of inhibiting STAT3 in a cell comprising contacting the cell with a compound of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure provides methods of using of the compounds disclosed herein for the treatment of cancer.
    Type: Application
    Filed: July 19, 2019
    Publication date: June 2, 2022
    Applicants: Board of Regents, The University of Texas System, The Methodist Hospital dba Houston Methodist Hospital
    Inventors: David John TWEARDY, Ren KONG, Uddalak BHARADWAJ, Moses Makokha KASEMBELI, Stephen T. C. WONG
  • STAT3 inhibitors
    Patent number: 11026905
    Abstract: Compounds as STAT3 inhibitors are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing conditions such as cancer, chronic inflammation, and fibrosis using the same, are described.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: June 8, 2021
    Assignees: Tvardi Therapeutics, Inc., Baylor College of Medicine
    Inventors: Sofia De Achaval, David John Tweardy
  • STAT3 INHIBITORS
    Publication number: 20210114980
    Abstract: Compounds as STAT3 inhibitors are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing conditions such as cancer, chronic inflammation, and fibrosis using the same, are described.
    Type: Application
    Filed: April 18, 2019
    Publication date: April 22, 2021
    Inventors: Sofia De Achaval WIED, William E. BAUTA, William R. CANTRELL, Jr., David John TWEARDY
  • STAT3 INHIBITORS
    Publication number: 20210038544
    Abstract: Compounds as STAT3 inhibitors are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing conditions such as cancer, chronic inflammation, and fibrosis using the same, are described.
    Type: Application
    Filed: October 22, 2020
    Publication date: February 11, 2021
    Inventors: Sofia De Achaval Wied, William E. Bauta, William R. Cantrell, JR., David John Tweardy