Abstract: Systems, methods, and computer-readable media are disclosed for proactively and adaptively rerouting data to a healthier path through network, as part of flow provisioning, based on environmental variables associated with devices in the network. The present technology includes identifying a routing path for forwarding traffic flows in a network, receiving diagnostic data of a routing device on the routing path. The diagnostic data include one or more environmental parameters associated with internal state and surroundings of the routing device. Further, the present technology includes comparing the diagnostic data of the routing device with a predetermined threshold and modifying, prior to a failure of the routing device, the routing path to bypass the routing device for at least a portion of the traffic flows based on the comparison between the diagnostic data of the routing device and the predetermined threshold.

Abstract: Atomic layer etching (ALE) of a substrate using a wafer scale wave of precisely controlled electrons is presented. A volume of gaseous plasma including diluent and reactive species and electrons of a uniform steady state composition is generated in a positive column of a DC plasma proximate the substrate. A corrosion layer is formed on the substrate by adsorption of the reactive species to atoms at the surface of the substrate. The substrate is positively biased to draw electrons from the volume to the surface of the substrate and impart energy to the electrons to stimulate electron transitions in the corrosion layer species, resulting in ejection of the corrosion layer species via electron stimulation desorption (ESD). The substrate is negatively biased to repel the electrons from the surface of the substrate back to the volume, followed by a zero bias to restore the steady state composition of the volume.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: A method for fulfilling a work task request using a modular autonomous vehicle is provided. The method includes transmitting a work task request specifying a work request to be performed by the modular autonomous vehicle, and identifying equipment required for performing the work task request. Once the work task request is stored at a server, the method further includes identifying information of the equipment required for performing the work task request, and determining whether equipment of the modular autonomous vehicle corresponds to the equipment required for assigning the work task to the modular autonomous vehicle. Method also includes, upon receiving in-cabin sensing data, assigning or denying the work task to the modular autonomous vehicle for performance of the work task.

Abstract: A mask system for delivery of respiratory therapy to a patient includes a nares portion and a mouth portion and an inlet conduit connected to at least one of the nares portion and the mouth portion to deliver the pressurized, breathable gas. The mask system is adapted to selectively utilize the nares portion and/or the mouth portion in a first mode utilizing both the nares portion and the mouth portion, and in a second mode utilizing the nares portion and not utilizing the mouth portion.

Abstract: Methods and materials for treating a mammal having a congenital disease (e.g., a congenital heart disease such as congenital long QT syndrome) are provided herein. For example, this document provides methods and materials for generating and using nucleic acids to treat a mammal having a congenital disease, where the nucleic acids can suppress expression of mutant disease-related alleles in the mammal while providing a replacement cDNA that does not contain the disease-related mutation(s).

Abstract: In one embodiment, a device obtains transaction data regarding a transaction attempted within a software development environment, wherein the transaction data is captured by instrumentation code inserted into the software development environment at runtime. The device identifies, based on the transaction data, an access policy for the transaction. The device makes, based on the access policy, a determination that the transaction is not authorized. The device causes, via the instrumentation code, the transaction to be blocked from completing within the software development environment.

Abstract: A robotic tool has a longitudinal shaft, defining a longitudinal axis when the shaft is in a default, centered position. A lockout rod is moveable between first and second positions. In the first position, the lockout rod allows the longitudinal shaft to move with 360 radial degrees of compliance about the longitudinal axis. In the second position, the lockout rod limits compliance of the longitudinal shaft to only one radial angle from the longitudinal axis. In one embodiment the lockout rod is positioned adjacent (e.g., above or below) part of one ring of a 2-axis concentric ring gimbal. The lockout rod is shaped so as to not contact any part of the gimbal in the first position, allowing compliance in a full 360 radial degrees. In the second position, the lockout rod limits the motion of one ring of the gimbal, limiting compliance of the shaft to motion of the other ring, which is necessarily limited to only one radial angle.

Abstract: An apparatus includes a body portion that defines a reservoir and a set of substantially flexible capillaries. The set of substantially flexible capillaries are fixedly coupled to the body portion and in fluid communication with the reservoir. A connector is configured to be coupled to the body portion to be in fluid communication with the reservoir and the set of substantially flexible capillaries. The connector is further configured to be coupled to a vacuum source. The apparatus is arranged such that at least a part of the body portion is electrically conductive. Methods for separating and detecting an analyte from a biological sample with the apparatus are also provided. For example, methods for separating and detecting one or more proteins from a cellular lysate or a purified protein are also provided.

Abstract: This application relates to a building energy analysis and management system for measurement and verification of building performance. The system can analyze, optimize, manage, maintain, trouble shoot, and/or modify building systems, such as HVAC systems, in connection with the building energy usage. Measurements may be gathered for one or more HVAC units coupled to pressure independent valves, and sent to one or more Surge Panels that pass data to remote analysis servers, which can receive other system or external data. The analysis servers compare measurements to predicted values and can standardize the predicted values to account for external conditions. The comparison can result in difference values used to generate probable causes and optimization recommendations. The system outputs reports or other data display using a graphical user interface that can be adjusted for an anticipated user.

Abstract: Techniques for a TCP proxy to communicate over a LEO satellite network on behalf of a client device by selecting a TCP congestion-control algorithm that is optimal for the LEO satellite network based on the time of day and/or location of the TCP proxy. Based on the locations of satellites during the day as they traverse predefined and patterned orbital paths, different TCP congestion-control algorithms may be more optimized to communicate data through the LEO satellite network. However, client devices generally use a single TCP congestion-control algorithm to communicate over WAN networks. Accordingly, a TCP proxy may be inserted on, for example, a router to communicate with the client device using a TCP congestion-control algorithm that the client device is configured to use, but then communicate over the LEO satellite network using a different TCP congestion-control algorithm that is optimal based on the time of day and/or other factors.

Abstract: Techniques for data manipulation using processor cluster address generation are disclosed. One or more processor clusters capable of executing software-initiated work requests are accessed. A plurality of dimensions from a tensor is flattened into a single dimension. A work request address field is parsed, where the address field contains unique address space descriptors for each of the plurality of dimensions, along with a common address space descriptor. A direct memory access (DMA) engine coupled to the one or more processor clusters is configured. Addresses are generated based on the unique address space descriptors and the common address space descriptor. The plurality of dimensions can be summed to generate a single address. Memory is accessed using two or more of the addresses that were generated. The addresses are used to enable DMA access.

Abstract: An air interface plane (AIP) of a radio frequency (RF) aperture includes: a circuit board having a first side and a second side opposite the first side; and a matrix of tapered elements arranged on the first side of the circuit board and secured to the circuit board, the matrix of tapered elements cooperating to at least one of receive or transmit an over-the-air RF signal. Suitably, each tapered element of the matrix has: a central hub extending along a longitudinal axis from a hub base which is proximate to the first side of the circuit board to an apex of the tapered element which is distal from the first side of the first circuit board; and a plurality of arms extending from the central hub at the apex of the tapered element, each of the plurality of arms including a first portion that projects the arm radially away from the longitudinal axis and a second portion that projects the arm longitudinally toward the first side of the circuit board.

Abstract: A system for applying material to a substrate includes a nozzle, robot, actuator, sensor, and controller. The robot provides primary movement such that the nozzle traverses a predefined global bead path across and spaced apart from the substrate. The actuator provides secondary relative movement between the nozzle and substrate. The sensor senses a first location on the substrate that is spaced apart from a location where the nozzle deposits material by a distance based on a sensor response time and relative speed of the nozzle and substrate. The controller detects a feature of the substrate based on the data received from the sensor. The controller directs the actuator to provide the secondary relative movement such that a bead of material is applied to the substrate along a feature-relative bead path. The controller controls the actuator to provide the secondary relative movement based on the response time and the relative speed.

Abstract: An automated teller machine comprises a communications module; an image module; a processor; and a memory coupled to the processor storing instructions that, when executed by the processor, configure the processor to receive a first cheque for deposit; engage the image module to capture an image of the first cheque; send, via the communications module and to a server computer system, a signal that includes the image of the first cheque for acceptance; send, via the communications module and to an automated teller machine switch, a signal that includes a request for transaction authorization approval based on the first cheque; receive, via the communications module and from the server computer system, a signal that includes an indication of acceptance of the image of the first cheque; receive, via the communications module and from the automated teller machine switch, a signal that includes an indication of approval of the request for the transaction authorization based on the first cheque; and responsive to r

Abstract: The display device of the present invention includes, in the following order toward a viewer: a display panel; a semi-transparent mirror; a Pancharatnam-Berry lens configured to cause one-handed circularly polarized light incident thereon that is left-handed circularly polarized light or right-handed circularly polarized light to converge while causing opposite-handed circularly polarized light incident thereon to diverge; and a circularly polarized light-selective reflector.

Abstract: Methods, systems, and computer-readable media for a service for managing quantum computing resources are disclosed. A task management service receives a description of a task specified by a client. From a pool of computing resources of a provider network, the service selects a quantum computing resource for implementation of the task. The quantum computing resource comprises a plurality of quantum bits. The service causes the quantum computing resource to run a quantum algorithm associated with the task. The service receives one or more results of the quantum algorithm from the quantum computing resource.

Abstract: The present disclosure provides human tumor necrosis factor alpha antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of autoimmune and inflammatory diseases.

Abstract: Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away front the printed part, resulting in a part having surface cavities.

Abstract: An example medical device for occluding the left atrial appendage includes an expandable member having a first end region, a second end region and an inflation cavity. The medical device also includes a plurality of spine members coupled to the expandable member, the plurality of spine members spaced circumferentially around an outer surface of the expandable member. Additionally, the medical device includes a valve member extending at least partially into the inflation cavity, wherein the plurality of spine members are configured to position the medical device within an opening of the left atrial appendage and wherein the expandable member is configured to expand and seal the opening of the left atrial appendage.