Abstract: Provided herein are compositions, systems, and methods comprising effector proteins, effector partners, and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and/or engineering of nucleic acids.

Abstract: Apparatuses, systems, and methods comprising acoustically absorptive air ducts comprising an internally positioned structure component as an endoskeleton and an air impervious inner layer, and an acoustically absorptive foam outer layer, environmental control systems comprising such air ducts, and vehicles incorporating such environmental control systems are disclosed with methods for manufacture and installations are disclosed.

Abstract: A cookware for use in an oven includes a heat maintaining body defining a cook surface, a plurality of heat conductive elements including a plurality of fins that extend from the heat maintaining body in a direction away from the cook surface, and can have a plurality of legs coupled to the fins. The legs can extend away from the heat maintaining body in a direction opposite the cook surface. The heat conductive elements are configured to conduct heat from a convective air flow to the heat maintaining body.

Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Nav1.1 activity and for treating or preventing conditions associated with Nav1.1 activity.

Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Nav1.1 activity and for treating or preventing conditions associated with Nav1.1 activity.

Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. In some embodiments, an isolated or recombinant CMR1 polypeptide is directly or indirectly attached to a detectable label or fused to a second polypeptide. In some embodiments, an isolated or recombinant CMR1 polypeptide is directly or indirectly bound to a solid support.

Abstract: A conductive ink and a conductive coating are provided. The conductive ink includes a conductive polymer solution comprising conductive polymer dissolved in an aqueous-based media and a mixture of carbon nanotubes and graphene oxide sheets dispersed in the conductive polymer solution, wherein a weight ratio of the carbon nanotubes to the graphene oxide sheets is in a range from 0.25 to 2.5. The conductive coating includes a conductive polymer and a mixture of graphene oxide sheets and carbon nanotubes dispersed in the conductive polymer, wherein a weight ratio of the carbon nanotubes to the graphene oxide sheets is in a range from 0.25 to 2.5, and wherein the conductive coating has an optical transmittance value at 550 nm of at least 75%.

Abstract: The disclosure is directed at a rack unit that provides an improved system and method for users to identify the ports within the rack unit. The rack unit includes a designation plate pivots between a lowered position where the user can identify the ports within the rack unit and a raised position where the user has more space to insert a cable into an identified port.

Abstract: A method of producing an aqueous dispersion of few-layer graphene nanosheets is disclosed, the method including: (a) mixing graphite particles with a perfluorosulfonate ionomer in an aqueous liquid, to form an aqueous dispersion of graphite particles; and (b) sonicating the aqueous dispersion of graphite particles to form an aqueous dispersion of few-layer graphene nanosheets, wherein the perfluorosulfonate ionomer is disposed as a thin and continuous layer on the few-layer graphene nanosheets. A composition is also disclosed, comprising an aqueous dispersion of a mixture of: (a) a perfluorosulfonate ionomer; and (b) a plurality of few-layer graphene nanosheets; wherein the perfluorosulfonate ionomer is disposed as a thin and continuous layer on the few-layer graphene nanosheets.

Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. In some embodiments, an isolated or recombinant CMR1 polypeptide is directly or indirectly attached to a detectable label or fused to a second polypeptide. In some embodiments, an isolated or recombinant CMR1 polypeptide is directly or indirectly bound to a solid support.

Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.

Abstract: A microneedle applicator. The applicator can include a microneedle array, a microneedle array holder, and an actuator movable between a first position and a second position to cause the microneedle array holder to move, respectively, between a retracted position and an extended position. The applicator can further include a first biasing element configured to bias the actuator in the first position, and a counter assembly, or mechanism, configured to count a number of times the microneedle array holder is moved between the retracted position and the extended position (or the number of times the actuator is moved from the first position to the second position). In some embodiments, the counter assembly can include the actuator and first biasing element.

Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.

Abstract: A conductive ink and a conductive coating are provided. The conductive ink includes a conductive polymer solution comprising conductive polymer dissolved in an aqueous-based media and a mixture of carbon nanotubes and graphene oxide sheets dispersed in the conductive polymer solution, wherein a weight ratio of the carbon nanotubes to the graphene oxide sheets is in a range from 0.25 to 2.5. The conductive coating includes a conductive polymer and a mixture of graphene oxide sheets and carbon nanotubes dispersed in the conductive polymer, wherein a weight ratio of the carbon nanotubes to the graphene oxide sheets is in a range from 0.25 to 2.5, and wherein the conductive coating has an optical transmittance value at 550 nm of at least 75%.

Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.

Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.

Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.

Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.

Abstract: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.