Patents by Inventor David K. Lavallee

David K. Lavallee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid synthesis of radiolabeled porphyrin complexes for medical application
    Patent number: 4783529
    Abstract: This invention relates to a novel method for the rapid synthesis of radiolabeled porphyrin complexes which are highly useful for biomedical application, i.e. conjugation to protein antibodies for use in tumor imaging and internal radiation therapy.
    Type: Grant
    Filed: December 3, 1985
    Date of Patent: November 8, 1988
    Assignee: Research Corporation Technologies
    Inventors: David K. Lavallee, Daniel Mansuy, Jean-Paul Battioni
  • N-Substituted metalloporphyrins as anti-tumor agents against PS-P-388(P388) leukemia in animals
    Patent number: 4386087
    Abstract: Alkylating agents have been found to have chemotherapeutic value in cancer treatment. The difficulty of altering the alkylation rate or specificity of alkylating agents is solved by methyl release from metallo N-methyl porphyrins in which the release rate is determined by the particular metal ion of the complex. Moreover, it has been shown that porphyrins accumulate specifically in tumors. Sodium aquo-N-methyltetra (p-sulfophenyl) porphinatocopper (II) trifluoromethanesulfonate has been shown to have activity against lymphocytic PS-P-388 (P388) leukemia in mammals. A wide range of N-substituents and metallo complexes, and their preparation are given. Anti-tumor use is demonstrated against P388 leukemia in animals.
    Type: Grant
    Filed: July 1, 1981
    Date of Patent: May 31, 1983
    Assignee: Research Foundation of the City University of New York
    Inventor: David K. Lavallee