Abstract: Disclosed herein are quantum dot devices, as well as related computing devices and methods. For example, in some embodiments, a quantum dot device may include: a quantum well stack; a first gate above the quantum well stack, wherein the first gate includes a first gate metal and a first gate dielectric; and a second gate above the quantum well stack, wherein the second gate includes a second gate metal and a second gate dielectric, and the first gate is at least partially between a portion of the second gate and the quantum well stack.

Abstract: The invention provides compositions and methods for treating cardiac dysfunction, particularly cachexia-associated or RAGE-associated cardiac dysfunction, using an anti-RAGE agent. The invention also provides compositions and methods for identifying therapeutic agents useful for disrupting (slowing, reducing, reversing, or preventing). The methods comprise designing or identifying agents that bind to functional sites identified on the RAGE polypeptide, wherein binding of agents to the functional site(s) inhibit RAGE-mediated cachetogenic signaling.

Abstract: The invention provides markers indicative of pre-cachexia, compositions and methods for identifying patients with a molecular signature indicative of pre-cachexia; a culture system that reproduces the cachetic process in cells in vitro, which facilitates the screening and identification of therapeutic agents useful for disrupting (slowing, reducing, reversing, or preventing) the progression of pre-cachexia to refractory cachexia; as well as therapeutic agents identified using the culture system of the invention.

Abstract: The invention provides markers indicative of pre-cachexia, compositions and methods for identifying patients with a molecular signature indicative of pre-cachexia; a culture system that reproduces the cachetic process in cells in vitro, which facilitates the screening and identification of therapeutic agents useful for disrupting (slowing, reducing, reversing, or preventing) the progression of pre-cachexia to refractory cachexia; as well as therapeutic agents identified using the culture system of the invention.

Abstract: The invention provides markers indicative of pre-cachexia, compositions and methods for identifying patients with a molecular signature indicative of pre-cachexia; a culture system that reproduces the cachetic process in cells in vitro, which facilitates the screening and identification of therapeutic agents useful for disrupting (slowing, reducing, reversing, or preventing) the progression of pre-cachexia to refractory cachexia; as well as therapeutic agents identified using the culture system of the invention.

Abstract: The invention provides compositions and methods for treating cardiac dysfunction, particularly cachexia-associated or RAGE-associated cardiac dysfunction, using an anti-RAGE agent. The invention also provides compositions and methods for identifying therapeutic agents useful for disrupting (slowing, reducing, reversing, or preventing). The methods comprise designing or identifying agents that bind to functional sites identified on the RAGE polypeptide, wherein binding of agents to the functional site(s) inhibit RAGE-mediated cachetogenic signaling.

Abstract: The invention provides therapeutic, engineered protein/peptide compositions comprising e.g., RAGE antibodies, T-cell receptors to target a RAGE receptor (including soluble forms thereof) directly and/or via differential competition with one or more pre-cachexia and/or cachexia-associated RAGE ligands or markers.

Abstract: The invention provides therapeutic, engineered protein/peptide compositions comprising e.g., RAGE antibodies, T-cell receptors to target a RAGE receptor (including soluble forms thereof) directly and/or via differential competition with one or more pre-cachexia and/or cachexia-associated RAGE ligands or markers.

Abstract: The invention provides markers indicative of pre-cachexia, compositions and methods for identifying patients with a molecular signature indicative of pre-cachexia; a culture system that reproduces the cachetic process in cells in vitro, which facilitates the screening and identification of therapeutic agents useful for disrupting (slowing, reducing, reversing, or preventing) the progression of pre-cachexia to refractory cachexia; as well as therapeutic agents identified using the culture system of the invention.

Abstract: A capacitance probe is used by a coordinate measuring machine or machine tool to determine distances from the probe to the workpiece surface at various points over the surface. The probe is calibrated by moving it along a line, which is skewed to the surface. During this movement, a plurality of values of the capacitance and the corresponding values of the actual distance moved along the line are recorded. A datum value for the movement along the skewed line is also determined, which corresponds to a position at which the probe would touch the surface. The probe is calibrated without needing separate independent measurements of the distance from the probe to the surface. The workpiece surface is scanned using the thus-calibrate probe, in which different calibration values are used at different points on the surface, in order to account for the local shape of the surface.

Abstract: A capacitance sensing probe is disclosed for taking measurements of features on a workpiece surface. The probe has two electrodes (E.sub.1, E.sub.2) spaced apart in the direction of movement of the probe with the electrodes being disposed in an attitude normal to the surface. Only the edge of the electrodes are exposed to the surface and an electric circuit (EC) is provided for determining the effect of the surface on the fringe field capacitance between the electrodes. Guard electrodes are used to reduce the stray capacitance being measured. Various embodiments are shown with different numbers and arrangements of electrodes.

Abstract: Probes (18A, 18B, 18C) can be interchangeably mounted in the spindle (12) of a machine tool. Each probe has an optical signal transmission system, in which an optical signal from a light emitting diode (24) is transmitted to a receiving photodiode (26). To prevent interference between the different probe signals, each probe modulates the emitted light at a different carrier frequency. The receiver (28) contains electronic bandpass filters to separate out the different carrier frequencies. The signal information is encoded onto the optical signal by phase modulation of the carrier frequency.

Abstract: A signal conditioning circuit for multiple channel capacitive displacement transducers. The transducer 30 comprises three differential capacitive transducers, driven by respective square waves from modulators 32x, 32y, 32z. The modulators are driven at different frequencies which are even multiples of each other, derived from a divider 68. The signals from each differential capacitance pair of the transducer 30 are received by a common charge amplifier 48. They are then demodulated by respective phase sensitive rectifiers 50x, 50y, 50z, each of which is driven at the same frequency as the corresponding modulator. The outputs of the phase sensitive rectifiers are integrated, e.g. by circuits 60,62,44 for one of the channels, and the resulting voltage signal is fed back to the corresponding modulator so as to tend to null the input to the charge amplifier 48. The use of modulating frequencies which are even multiples of each other enables the signals to be multiplexed through a single charge amplifier 48.

Abstract: An electronic game simulates a shove-a-coin game by causing successive illumination of lights on a display, which simulates movement of a coin, in response to the activation of a control button. The final position of the "coin" relative to a scale is determined by the speed, or total distance of movement, of the button, and that final position determines the result of the game, which may be indicated by suitable indicators adjacent the scale. The control of the movement of the "coin" is such that, for speeds or distances of movement of the button less than a first value, the "coin" does not move, whereas for speeds or distances of movement of the button greater than a second value, the "coin" moves to an end position, corresponding to a losing result. Thus the skill of the game is to activate the button by the right amount to cause the "coin" to move to a winning position at some intermediate point along the scale.

Abstract: A stylus (15) for contacting a workpiece (13) to sense its position is suspended on a movable member (16) within a fixed housing (10). The suspension is by means of three connecting units (20, 30, 40). Taking the connecting unit (20)as an example, the movable member (16) is connected to an intermediate member (22) by a first pair of links (21), while the intermediate member (22) is connected to the fixed housing by a second pair of links (23). The pairs of links are rigid in tension and compression so as to prevent rotation of the stylus about a respective one of the three orthogonal axes X, Y, Z. Nevertheless, the links permit translational movement along all three axes. The similar connecting units (30, 40) likewise permit translation on all three axes, while preventing rotation about a respective one of the axes.

Abstract: A color gravure printing press of simple construction which is easy to set up and operate, and is therefore economic for use in printing short runs comprises printing members (2) for at least two different colors arranged around a common printing cylinder (1), an impression cylinder (3) including means (11) to hold a sheet of substrate (15) to be printed, and at least as many inking assemblies (4) as there are different color printing members (2) arranged around the printing cylinder (1). Each of the inking assemblies (4) includes a doctor blade (35) movable towards and away from the printing cylinder (1). The press is arranged so that each inking assembly (4) applies ink only to its corresponding printing member (2) and each doctor blade (35) contacts only its corresponding printing member (2), and that the substrate (15) is held in a fixed position on the impression cylinder (3) until it has been contacted and printed by all of the different color printing members ( 2).